Genes up and down regulated in response to ER stress
Chaubey S, Grover M, Tatu U. Endoplasmic reticulum stress triggers gametocytogenesis in the malaria parasite. J Biol Chem. 2014 289(24):16662-74. PMID:24755215
Genes upregulated in response to DTT treatment
Increase is shown only up to 2-fold by declining order
GeneName Annotation Fold change E.C Transcript
22651 PF3D7_1221400 inner membrane complex protein 1h, putative 6.17
22616 PF3D7_0532200
Plasmodium exported protein (PHISTc), unknown function 5.38
22598 PF3D7_0101500 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 4.58
22652 PF3D7_1226100 haloacid dehalogenase-like hydrolase, putative 4.48 3.1.3.1
22617 PF3D7_0601400 erythrocyte membrane protein 1 (PfEMP1), pseudogene 4.23
23560 PF3D7_0931300 conserved plasmodium protein, unknown function 3.89
24568 PF3D7_0801900
lysine-specific histone demethylase, putative 3.43 1.4.3.4
22646 PF3D7_1147200 tubulin--tyrosine ligase, putative 3.33 6.3.2.25
22678 PF3D7_1407700 conserved Plasmodium protein, unknown function 3.29
22676 PF3D7_1401500 esterase, putative 3.27 3.1.1.5
22679 PF3D7_1410100
alpha/beta hydrolase, putative 3.14
22655 PF3D7_1248400 conserved Plasmodium protein, unknown function 3.07
22596 PF3D7_0100200 PIR protein rifin 3.02
22667 PF3D7_1347400 conserved Plasmodium protein, unknown function 2.97
22621 PF3D7_0623400 mei2-like RNA-binding protein, putative, mei2 2.96
22597 PF3D7_0100900 rifin PIR protein 2.70
22629 PF3D7_0904200 PH domain-containing protein, putative 2.70
22690 PF3D7_1461700 conserved Plasmodium protein, unknown function 2.68
22626 PF3D7_0732900 PIR protein rifin 2.67
22658 PF3D7_1254100
PIR protein stevor 2.66
22601 PF3D7_0216000 DEAD/DEAH box helicase, putative 2.66 3.6.4.13
22662 PF3D7_1316000
protein kinase, putative 2.66 2.7.11.1
22634 PF3D7_0932600 apicoplast ribosomal protein S6, putative 2.64
22641 PF3D7_1041200 rifin PIR protein 2.63
27695 PF3D7_0516500
major facilitator superfamily domain-containing protein, putative, MFS1 2.60
22660 PF3D7_1303900 GINS complex, subunit Psf3 2.55
22640 PF3D7_1035800 probable protein, unknown function 2.49
22656 PF3D7_1252200
chitinase 2.49 3.2.1.14
22642 PF3D7_1123100
calcium-dependent protein kinase 7 2.45 2.7.11.17
22622 PF3D7_0625500 conserved Plasmodium membrane protein, unknown function 2.43
22682 PF3D7_1431100 PhIL1 interacting protein PIP2 2.39
22615 PF3D7_0525000 zinc finger protein, putative 2.38
22683 PF3D7_1431300 large subunit GTPase 1, putative 2.38 3.6.5.1
22648 PF3D7_1217100 meiotic recombination protein SPO11, putative 2.37 5.99.1.3
22649 PF3D7_1218800 secreted ookinete protein, putative 2.32
22608 PF3D7_0411000 conserved Plasmodium protein, unknown function 2.31
22604 PF3D7_0309700 SECIS-binding protein 2, putative 2.30
22664 PF3D7_1329700
apicoplast calcium binding protein 1 2.29
22611 PF3D7_0513700 secreted ookinete protein, putative 6-cysteine protein 2.28
24766 PF3D7_1401300
proline aminopeptidase 2.26 3.4.11.5
22650 PF3D7_1221300 conserved Plasmodium protein, unknown function 2.25
22661 PF3D7_1307100 U3 small nucleolar RNA-associated protein 6, putative 2.24
23899 PF3D7_1319600 acdc domain-containing protein, putative 2.24
22693 PF3D7_1473600 conserved Plasmodium protein, unknown function 2.21
22607 PF3D7_0410000
erythrocyte vesicle protein 1 2.18
22606 PF3D7_0404400 6-cysteine protein p36 2.17
22638 PF3D7_1020800
dihydrolipoamide acyltransferase component E2 2.16 2.3.1.12
22684 PF3D7_1436900
histidine triad protein, putative 2.15 3.6.1.29
22654 PF3D7_1239000 HD superfamily phosphohydrolase protein 2.15 3.1.4.17
22681 PF3D7_1430100
serine/threonine protein phosphatase 2A activator 2.15
22635 PF3D7_0934600 conserved Plasmodium protein, unknown function 2.13
22618 PF3D7_0601900
conserved Plasmodium protein, unknown function 2.12
22603 PF3D7_0304900 conserved Plasmodium protein, unknown function 2.11
22668 PF3D7_1350200 small nuclear ribonucleoprotein E, putative 2.11
22687 PF3D7_1445600 RNA-binding protein, putative 2.10
22624 PF3D7_0702600 chitinase, fragment 2.08
22599 PF3D7_0113700
heat shock protein 40, type II 2.08
22689 PF3D7_1450300
NADPH--cytochrome P450 reductase, putative 2.07
22630 PF3D7_0907600 translation initiation factor SUI1, putative 2.04
22609 PF3D7_0424700
serine/threonine protein kinase, FIKK family 2.04 2.7.11.1
22677 PF3D7_1402700 U2 snRNP-associated SURP motif-containing protein, putative 2.01
23571 PF3D7_1139300 ap2 domain transcription factor ap2-g5, putative 2.01
23955 PF3D7_1342900 ap2 domain transcription factor ap2-hs 2.01
Genes downregulated in response to DTT treatment
Decrease is shown as percents of control, only down to 40 % in declining order
GeneName % decrease
22631 PF3D7_0923800
thioredoxin reductase 94.5 1.8.1.9
22639 PF3D7_1034700 ADP-ribosylation factor, putative 63.2
22628 PF3D7_0823900
dicarboxylate/tricarboxylate carrier, DTC 59.5
22686 PF3D7_1439000
copper transporter, CTR1 55.5
22691 PF3D7_1466100 protein phosphatase containing kelch-like domains 54.9
22647 PF3D7_1202400
peptidyl-prolyl cis-trans isomerase 50.7 5.2.1.8
22610 PF3D7_0424800 Plasmodium exported protein (PHISTb), unknown function 50.1
22692 PF3D7_1467400
50S ribosomal protein L22, apicoplast, putative 48.7
22669 PF3D7_1352800 vacuolar fusion protein MON1, putative 48.3
22674 PF3D7_1373400 PIR protein rifin 48.1
27649 PF3D7_0927000 Hsp90 co-chaperone p23 47.8
22680 PF3D7_1421900
copper transporter, putative, CTR2 47.2
22673 PF3D7_1369000 glycosylphosphatidylinositol anchor attachment 1 protein, putative 46.9
22636 PF3D7_0936200 Plasmodium exported protein (hyp11), unknown function 45.1
22659 PF3D7_1300200 rifin PIR protein 44.2
22672 PF3D7_1367500
NADH-cytochrome b5 reductase, putative 44.1 1.6.2.2
22620 PF3D7_0612700
6-cysteine protein p12 43.6
22614 PF3D7_0518300
proteasome subunit beta type-1, putative 43.0 3.4.25.1
22600 PF3D7_0115700
erythrocyte membrane protein 1, PfEMP1 42.9
22688 PF3D7_1446600
centrin-2 42.5
22619 PF3D7_0608500 proteasome subunit alpha type-2, putative 42.2 3.4.25.1
22671 PF3D7_1367000 suppressor of kinetochore protein 1, putative 42.2
22625 PF3D7_0715300 calcium/calmodulin-dependent protein kinase, putative 41.8 2.7.11.17
22653 PF3D7_1230400
ATP-dependent protease subunit ClpQ 40.8 3.5.1.98
22623 PF3D7_0632500 erythrocyte membrane protein 1, PfEMP1 40.7
22637 PF3D7_1005000
methionine--tRNA ligase, putative 40.6 6.1.1.10
22643 PF3D7_1132800
aquaglyceroporin 40.4
22665 PF3D7_1330400 ER lumen protein retaining receptor 1, putative 40.4
30674 PF3D7_0317000 proteasome subunit alpha type-3, putative 40.2 3.4.25.1
22644 PF3D7_1134100
protein disulfide isomerase, putative 40.2 5.3.4.1
22685 PF3D7_1438100 secretory complex protein 62 40.2
22657 PF3D7_1252700
Plasmodium exported protein (PHISTb), unknown function 39.9
22602 PF3D7_0223500 erythrocyte membrane protein 1, PfEMP1 39.8
30686 PF3D7_1353900 proteasome subunit alpha type-7, putative 39.7 3.4.25.1
22613 PF3D7_0517900 zinc finger protein, putative 39.6
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