Highly Variable  Genes
Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR,Le Roch K, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog. 2006 2(6):e57. PMID: 16789840;
PfID Annotation Number of single-feature polymorphism (SFPs) Life-cycle stage–expression Pexel motif HT motif SignalP TM domain EC Transcript
Le Roch et al. Bozdech et al.
PF3D7_1035200
S-antigen 10 Schizont Late schizont No No Yes 0
PF3D7_0202000
knob-associated histidine-rich protein 56 Ring/Trophozoite Late ring Yes Yes No 0
PF3D7_1401000 GBPH protein 14 Trophozoite 0 Yes Yes No 1
PF3D7_0201900
erythrocyte membrane protein 3 60 Ring/Trophozoite 0 Yes Yes Yes 1
PF3D7_0935400
gametocyte development protein 1 38 Schizont/Gametocyte 0 No No No 0
PF3D7_0937200 lysophospholipase, putative 22 Low expression 0 No No No 0 3.1.1.5
PF3D7_0425200 Plasmodium exported protein (hyp15), unknown function 12 Merozoite 0 No No Yes 2
PF3D7_0930300
merozoite surface protein 1 106 Schizont Late schizont No No Yes 1
PF3D7_0302200
cytoadherence linked asexual protein 3.2 21 Schizont Late schizont No No Yes 0
PF3D7_1035400
merozoite surface protein 3 14 Schizont Late schizont No No Yes 0
PF3D7_1253400 acyl-CoA synthetase 22 Schizont/Gametocyte 0 No No Yes 0 6.2.1.3
PF3D7_0302500
cytoadherence linked asexual protein 3.1 23 Schizont Late schizont No No Yes 0
PF3D7_1335300
reticulocyte binding protein 2 homologue b, ALKBH5 19 Schizont Late schizont No No No 1
PF3D7_1224000 GTP cyclohydrolase I 11 Trophozoite/Gametocyte Late trophozoite No No No 0 3.5.4.16
PF3D7_1335900 sporozoite surface protein 2 thrombospondin-related anonymous protein 19 Sporozoite 0 No No Yes 0
PF3D7_0206800
merozoite surface protein 2 12 Schizont Very late schizont No No No 0
PF3D7_1036400 liver stage antigen 1 16 Low expression 0 No No No 1
PF3D7_1133400
apical membrane antigen 1 18 Schizont Very late schizont No No Yes 1
PF3D7_1371600 erythrocyte binding like protein 1, pseudogene 62 Low expression 0 No No No 0
PF3D7_0729200
1-cys peroxiredoxin 3 Low expression 0 No No No 0 1.11.1.15
PF3D7_1035500
merozoite surface protein 6 6 Schizont Late schizont No No No 0
PF3D7_1004800 ADP, ATP carrier protein 2, aac2 7 Constitutive 0 No No No 5
PF3D7_1038400
gametocyte-specific protein 97 Sporozoite/Gametocyte 0 No No No 1
PF3D7_0304600 circumsporozoite (CS) protein 5 Sporozoite 0 No No No 1
PF3D7_0814900
superoxide dismutase [Fe] 4 Trophozoite 0 No No No 0 1.15.1.1
PF3D7_0731500
erythrocyte binding antigen-175 25 Ring 0 No No No 0
PF3D7_1115300
falcipain 2' cysteine proteinase falcipain 2b 3 Ring/Trophozoite Late ring No No No 1 3.4.22.-
PF3D7_0301000 acyl-CoA synthetase 15 Constitutive 0 No No No 0 6.2.1.3
PF3D7_0918100 cytochrome b5-like heme/steroid binding protein, putative 3 Ring/Trophozoite Very late schizont No No No 0
PF3D7_0307400
ATP-dependent Clp protease proteolytic subunit 4 Trophozoite Very late schizont No No No 0 3.4.21.92
PF3D7_1335100
merozoite surface protein 7 5 Schizont Late schizont No No No 0
PF3D7_0527100 ubiquitin-conjugating enzyme E2 13 3 Constitutive 0 No No No 0 6.3.2.19
PF3D7_0717300 transcription initiation factor IIE subunit alpha, putative 5 Constitutive 0 No No Yes 1
PF3D7_1367000 suppressor of kinetochore protein 1, putative 2 Trophozoite Very late schizont No No No 0
PF3D7_0207000
merozoite surface protein 4 4 Sporozoite/Schizont Very late schizont No No No 2
PF3D7_0319600 elongation factor 1-delta, putative 2 Constitutive 0 No No Yes 0
PF3D7_0220800
cytoadherence linked asexual protein 2 18 Schizont Late schizont No No No 0
PF3D7_0710900 50S ribosomal protein L1, mitochondrial, putative 4 Ring/Trophozoite 0 No No No 0
PF3D7_0528700 peptidyl-prolyl cis-trans isomerase 3 Constitutive 0 No No No 0 5.2.1.8
PF3D7_0519300
protoheme ix farnesyltransferase COX10 7 Trophozoite 0 No No No 4 2.5.1.B36
PF3D7_0305700 ubiquitin-conjugating enzyme mms2, putative 2 Constitutive 0 No No No 0 6.3.2.19
PF3D7_0708300
EKC/KEOPS complex subunit BUD32 2 Constitutive Late ring No No No 0 2.7.11.2
PF3D7_0215100 RING zinc finger protein, putative 3 Schizont 0 Yes No No 0
PF3D7_1149200
ring-infected erythrocyte surface antigen 12 Ring 0 No No No 0
PF3D7_0717400 queuine tRNA-ribosyltransferase, putative 7 Ring/Early trophozoite 0 No No No 0 2.4.2.29
PF3D7_1241600 S-adenosylmethionine mitochondrial carrier protein, SAMC 3 Constitutive 0 No No No 4
PF3D7_0501400 interspersed repeat antigen 9 Ring Very late schizont No No No 0
PF3D7_0919500 major facilitator superfamily domain-containing protein, MFS3 4 Sporozoite 0 No No No 11
PF3D7_0921000 ubiquitin-conjugating enzyme E2, putative 2 Constitutive 0 No No No 0 2.3.2.2
PF3D7_1115700
cysteine proteinase falcipain 2a falcipain 2 2 Ring/Trophozoite Late ring No No No 1 3.4.22.-
PF3D7_0516900 60S ribosomal protein L2 3 Ring/Trophozoite Late ring No No No 0
PF3D7_0528500 F-actin-capping protein subunit alpha, putative 3 Trophozoite/Gametocyte 0 No No No 0
PF3D7_1239600 hydroxyethylthiazole kinase 3 Constitutive 0 Yes Yes No 0 2.7.1.50
PF3D7_1002100
EMP1-trafficking protein 5 Ring Very late schizont No No No 1
PF3D7_0709000
chloroquine resistance transporter 4 Ring/Trophozoite Late ring No No No 10
PF3D7_0934500 V-type proton ATPase subunit E, putative 2 Constitutive 0 No No Yes 0 3.6.3.14
PF3D7_1121600
parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen 2 Ring/Trophozoite Very late schizont No No No 1
PF3D7_1144900
ras-related protein Rab-6 2 Schizont 0 No No 0 3.6.5.2
PF3D7_0207600
serine repeat antigen 5 11 Schizont/Gametocyte Late schizont No No No 0 3.4.22.-
PF3D7_1124600
ethanolamine kinase 4 Schizont/Gametocyte Late schizont No No No 0 2.7.1.82
PF3D7_0711500 regulator of chromosome condensation, putative 7 Constitutive 0 No No No 0
PF3D7_1023200 orotidine 5'-phosphate decarboxylase 3 Constitutive Late schizont No No No 0 4.1.1.23
PF3D7_0207900 serine repeat antigen 2 10 Schizont 0 No No No 0 3.4.22.-
PF3D7_0424300 erythrocyte binding antigen-165, pseudogene 17 Schizont 0 No No Yes 1
PF3D7_0612900 nucleolar GTP-binding protein 1, putative 6 Constitutive No No No 0
PF3D7_0809200 asparagine-rich antigen Pfa55-14 8 Gametocyte No No No 0
Le Roch KG, Zhou Y, Blair PL, Grainger M, Moch JK, et al. (2003) Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 301: 1503–1508.
Bozdech Z, Llinas M, Pulliam BL, Wong ED, Zhu J, et al. (2003) The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol 1: E5
Online articles related to Highly Variable Genes retrieved from PubMed