| Candidate Malaria Resistance Genes |
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| Damena D, Agamah FE, Kimathi PO, Kabongo NE, Girma H, Choga WT, Golassa L, Chimusa ER. Insilico Functional Analysis of Genome-Wide Dataset From 17,000 Individuals Identifies Candidate Malaria Resistance Genes Enriched in Malaria Pathogenic Pathways. Front Genet. 2021 12:676960. PMID: 34868193 |
| Genes |
Symbols |
Annotation |
Independent significant SNP |
|
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| ENSG00000160323 |
ADAMTS13 |
ADAM metallopeptidase with thrombospondin type 1 motif 13 |
rs8176751; |
rs687621 |
|
| ENSG00000197859 |
ADAMTSL2 |
ADAMTS like 2 |
rs8176751 |
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| ENSG00000179674 |
ARL14 |
ADP ribosylation factor like GTPase 14 |
rs116423146 |
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| ENSG00000058668 |
ATP2B4 |
ATPase, Ca++ transporting, plasma membrane 4 |
rs4951370 |
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| ENSG00000169255 |
B3GALNT1 |
beta-1,3-N-acetylgalactosaminyltransferase 1 |
rs116423146 |
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| ENSG00000159388 |
BTG2 |
BTG family member 2 |
rs4951370 |
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| ENSG00000110148 |
CCKBR |
cholecystokinin B receptor |
rs113892119:rs28576676 |
| ENSG00000133063 |
CHIT1 |
chitinase 1 |
rs4951370 |
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| ENSG00000113758 |
DBN1 |
drebrin 1 |
rs687621 |
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| ENSG00000122176 |
FMOD |
fibromodulin |
rs4951370 |
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| ENSG00000183090 |
FREM3 |
FRAS1 related extracellular matrix 3 |
rs201510180 |
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| ENSG00000109458 |
GAB1 |
GRB2 associated binding protein 1 |
rs111374053 |
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| ENSG00000148288 |
GBGT1 |
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 |
rs687621 |
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| ENSG00000250361 |
GYPB |
glycophorin B (MNS blood group) |
rs201510180 |
|
| ENSG00000197465 |
GYPE |
glycophorin E (MNS blood group) |
rs34330779 |
|
| ENSG00000244734 |
HBB |
hemoglobin subunit beta |
rs334 |
|
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| ENSG00000223609 |
HBD |
hemoglobin subunit delta |
rs334; rs4290259 |
|
| ENSG00000213931 |
HBE1 |
hemoglobin subunit epsilon 1 |
rs145843585 |
|
| ENSG00000213934 |
HBG1 |
hemoglobin subunit gamma 1 |
rs7927066 |
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| ENSG00000196565 |
HBG2 |
hemoglobin subunit gamma 2 |
rs145843585; rs183322782; rs148179286; rs7927066; rs11037724 |
| ENSG00000278828 |
HIST1H3H |
histone cluster 1, H3h |
rs8176751 |
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| ENSG00000122188 |
LAX1 |
lymphocyte transmembrane adaptor 1 |
rs4951370 |
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| ENSG00000148297 |
MED22 |
mediator complex subunit 22 |
rs8176751; rs687621 |
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| ENSG00000108960 |
MMD |
monocyte to macrophage differentiation-associated |
rs8176751 |
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| ENSG00000167346 |
MMP26 |
matrix metallopeptidase 26 |
rs141862673; rs145429724 |
| ENSG00000169251 |
NMD3 |
NMD3 ribosome export adaptor |
rs116423146 |
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| ENSG00000184881 |
OR51B2 |
olfactory receptor family 51 subfamily B member 2 |
rs145843585 |
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| ENSG00000176925 |
OR51F2 |
olfactory receptor family 51 subfamily F member 2 |
rs141862673; rs145429724; |
| ENSG00000176798 |
OR51L1 |
olfactory receptor family 51 subfamily L member 1 |
rs113892119:rs28576676 |
| ENSG00000182070 |
OR52A1 |
olfactory receptor family 52 subfamily A member 1 |
rs116780407 |
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| ENSG00000228474 |
OST4 |
oligosaccharyltransferase complex subunit 4 (non-catalytic) |
rs8176751 |
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| ENSG00000142657 |
PGD |
phosphogluconate dehydrogenase |
rs687621 |
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| ENSG00000143850 |
PLEKHA6 |
pleckstrin homology domain containing A6 |
rs4951370 |
|
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| ENSG00000163590 |
PPM1L |
protein phosphatase, Mg2+/Mn2+ dependent 1L |
rs116423146 |
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| ENSG00000188783 |
PRELP |
proline/arginine-rich end leucine-rich repeat protein |
rs4951370 |
|
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| ENSG00000170955 |
PRKCDBP |
protein kinase C, delta binding protein |
rs28576676 |
|
| ENSG00000160271 |
RALGDS |
ral guanine nucleotide dissociation stimulator |
rs8176751; rs687621 |
|
| ENSG00000148300 |
REXO4 |
REX4 homolog, 3'-5' exonuclease |
rs8176751 |
|
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| ENSG00000080345 |
RIF1 |
replication timing regulatory factor 1 |
rs8176751 |
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| ENSG00000170153 |
RNF150 |
ring finger protein 150 |
rs111374053 |
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| ENSG00000136193 |
SCRN1 |
secernin 1 |
rs687621 |
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| ENSG00000160326 |
SLC2A6 |
solute carrier family 2 (facilitated glucose transporter), member 6 |
rs8176719; rs687621 |
|
| ENSG00000196542 |
SPTSSB |
serine palmitoyltransferase small subunit B |
rs116423146 |
|
| ENSG00000148290 |
SURF1 |
surfeit 1 |
rs8176751; rs687621 |
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| ENSG00000148291 |
SURF2 |
surfeit 2 |
rs8176751 |
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| ENSG00000148248 |
SURF4 |
surfeit 4 |
rs8176751 |
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| ENSG00000148296 |
SURF6 |
surfeit 6 |
rs8176751; rs687621 |
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| ENSG00000196628 |
TCF4 |
transcription factor 4 |
rs687621 |
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| ENSG00000132109 |
TRIM21 |
tripartite motif containing 21 |
rs28576676 |
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| ENSG00000132274 |
TRIM22 |
tripartite motif containing 22 |
rs28576676 |
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| ENSG00000258659 |
TRIM34 |
tripartite motif containing 34 |
rs183322782; rs148179286 |
| ENSG00000213186 |
TRIM59 |
tripartite motif containing 59 |
rs116423146 |
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| ENSG00000121236 |
TRIM6 |
tripartite motif containing 6 |
rs28576676 |
|
| ENSG00000258588 |
TRIM6-TRIM34 |
TRIM6-TRIM34 readthrough |
rs183322782; rs148179286; rs28576676 |
| ENSG00000167333 |
TRIM68 |
tripartite motif containing 68 |
rs10837488; rs4290259:rs113892119 :rs28576676 |
| ENSG00000175518 |
UBQLNL |
ubiquilin-like |
rs11037724 |
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| ENSG00000109445 |
ZNF330 |
zinc finger protein 330 |
rs111374053 |
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