Predicted protein-protein interactions of plausible stress helicases
Tuteja R. Emerging functions of helicases in regulation of stress survival in malaria parasite Plasmodium falciparum and their comparison with human host. Parasitol Int. 2016 Aug 30 PubMed:27586396
Helicase helicase PfID PFID Name of interacting partners E.C Transcript
21201 DDX3 PF3D7_0810600 PF3D7_0103600
ATP-dependent DNA/RNA helicase psh1 3.6.4.13
21210 PF3D7_0315100
eukaryotic translation initiation factor 4E
21262 PF3D7_1107300 polyadenylate-binding protein-interacting protein 1, putative
21286 PF3D7_1342000 40S ribosomal protein S6
21205 PF3D7_0209800
ATP-dependent RNA helicase UAP56 3.6.4.13
21220 PF3D7_0517700 eukaryotic translation initiation factor 3 subunit B, putative
21306 PF3D7_1451100
elongation factor 2
21303 PF3D7_1445900
ATP-dependent RNA helicase ddx17 3.6.4.13
21263 PF3D7_1110200 pre-mRNA-processing factor 6, putative
21213 PF3D7_0415900 60S ribosomal protein L15, putative
21301 PF3D7_1439100 DEAD/DEAH box helicase, putative 3.6.4.13
29809 PF3D7_1224300
polyadenylate-binding protein 1, putative
21229 PF3D7_0719600 60S ribosomal protein L11a, putative
21237 PF3D7_0821300 ATP-dependent RNA helicase  dhx36, putative 3.6.4.13
21296 PF3D7_1419100
ATP-dependent RNA helicase ddx55 3.6.4.13
21210 PF3D7_0315100
eukaryotic translation initiation factor 4E
21240 PF3D7_0917600
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative 3.6.4.13
21255 DDX3 X/Y PF3D7_1031500 PF3D7_1030100
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative 3.6.4.13
21262 PF3D7_1107300 polyadenylate-binding protein-interacting protein 1, putative
21289 PF3D7_1364300
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 3.6.4.13
21286 PF3D7_1342000 40S ribosomal protein S6
21301 PF3D7_1439100 DEAD/DEAH box helicase, putative 3.6.4.13
21263 PF3D7_1110200 pre-mRNA-processing factor 6, putative
21239 PF3D7_0827000 ATP-dependent RNA helicase DBP10, putative 3.6.4.13
21225 PF3D7_0602100 ATP-dependent RNA helicase, mtr4 3.6.4.13
21231 PF3D7_0728000 eukaryotic translation initiation factor 2 subunit alpha, putative
21277 PF3D7_1232100
60 kDa chaperonin
21252 PF3D7_1015600
heat shock protein 60
21310 DDX41 PF3D7_0527900 PF3D7_0622200 tRNA-2-methylthio-n(6)-dimethylallyladenosine synthase 2.1.1.-
21251 PF3D7_1013100 U3 small nucleolar RNA-associated protein 13, putative
21237 PF3D7_0821300 ATP-dependent RNA helicase  dhx36, putative 3.6.4.13
21227 PF3D7_0615500 cdc2-related protein kinase 5 2.7.11.22
29809 PF3D7_1224300
polyadenylate-binding protein 1, putative
21304 PF3D7_1448000 U3 small nucleolar RNA-associated protein 12, putative
27555 PF3D7_1140500
myosin K, putative
21244 PF3D7_0920900 U4/U6 snRNA-associated-splicing factor, putative
23839 PF3D7_1223800 citrate/oxoglutarate carrier protein, putative
23878 PF3D7_0821600 polyribonucleotide 5'-hydroxyl-kinase clp1, putative
21217 PF3D7_0508200
longevity-assurance (LAG1) protein, putative 2.3.1.24
21291 PF3D7_1403700
translocation associated membrane protein, putative 2.3.1.24
21255 PF3D7_1030100
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative 3.6.4.13
21308 PF3D7_1467500 DNA/RNA-binding protein KIN17, putative
25753 PF3D7_0933000 cstf domain-containing protein, putative
21243 DDX1/  Dbp2p PF3D7_0521700 PF3D7_0920800
inosine-5'-monophosphate dehydrogenase 1.1.1.205
21298 PF3D7_1433500
DNA topoisomerase 2 5.99.1.3
21221 PF3D7_0520100 protein phosphatase PPM9, putative 3.1.3.16
21259 PF3D7_1105700 tRNA-splicing ligase RTCB 6.5.1.3
21223 PF3D7_0521500 ribosomal large subunit pseudouridylate synthase, putative 4.2.1.70
21250 PF3D7_1012600
GMP synthase [glutamine-hydrolyzing] 6.3.5.2
21203 PF3D7_0206500 conserved Plasmodium protein, unknown function
23572 PF3D7_1139300 ap2 domain transcription factor ap2-g5, putative
27616 PF3D7_0521300 zinc finger protein, putative
21242 PF3D7_0918900
gamma-glutamylcysteine synthetase 6.3.2.2
21232 PF3D7_0729400 ribosome biogenesis protein BRX1 homolog, putative
21237 PF3D7_0821300 ATP-dependent RNA helicase  dhx36, putative 3.6.4.13
23790 PF3D7_1015800
ribonucleoside-diphosphate reductase small chain, putative 1.17.4.1
21290 PF3D7_1366500
nucleoside diphosphate kinase 2.7.4.6
23426 PF3D7_1405600
ribonucleoside-diphosphate reductase small chain, putative 1.17.4.1
21300 DDX21/  Dbp1p or Gu-α PF3D7_0504400 PF3D7_1437200
ribonucleoside-diphosphate reductase large subunit, putative 1.17.4.1
21219 PF3D7_0509400
RNA polymerase I 2.7.7.6
21265 PF3D7_1134700 DNA-directed RNA polymerase I subunit RPA2, putative 2.7.7.6
29892 PF3D7_1307600
DNA-directed RNA polymerase subunit alpha, putative 2.7.7.6
21267 PF3D7_1143300 DNA-directed RNA polymerases I and III subunit RPAC1, putative 2.7.7.6
21255 PF3D7_1030100
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative 3.6.4.13
21284 PF3D7_1329000 DNA-directed RNA polymerase III subunit RPC1, putative 2.7.7.6
21269 PF3D7_1206600 DNA-directed RNA polymerase III subunit RPC2, putative 2.7.7.6
21212 PF3D7_0318200 DNA-directed RNA polymerase II subunit RPB1 2.7.7.6
21206 PF3D7_0215700 DNA-directed RNA polymerase II subunit RPB2 2.7.7.6
21257 PF3D7_1037100
pyruvate kinase 2, pyrkii 2.7.1.40
21245 PF3D7_0923000 DNA-directed RNA polymerase II subunit RPB3 2.7.7.6
21273 PF3D7_1220100 pre-mRNA-processing factor 17, putative
21209 PF3D7_0308600 pre-mRNA-processing factor 19, putative
21219 PF3D7_0509400
RNA polymerase I 2.7.7.6
21202 DHX36 PF3D7_0821300 PF3D7_0110400 DNA-directed RNA polymerase II subunit RPB9, putative 2.7.7.6
21226 PF3D7_0605600
nucleoside diphosphate kinase, putative 2.7.4.6
21265 PF3D7_1134700 DNA-directed RNA polymerase I subunit RPA2, putative 2.7.7.6
21290 PF3D7_1366500
nucleoside diphosphate kinase 2.7.4.6
21294 PF3D7_1415200 DNA-directed RNA polymerases I and III subunit RPAC2, putative 2.7.7.6
21284 PF3D7_1329000 DNA-directed RNA polymerase III subunit RPC1, putative 2.7.7.6
21206 PF3D7_0215700 DNA-directed RNA polymerase II subunit RPB2 2.7.7.6
21269 PF3D7_1206600 DNA-directed RNA polymerase III subunit RPC2, putative 2.7.7.6
21267 PF3D7_1143300 DNA-directed RNA polymerases I and III subunit RPAC1, putative 2.7.7.6
21212 PF3D7_0318200 DNA-directed RNA polymerase II subunit RPB1 2.7.7.6
21204 PF3D7_0206600 DNA-directed RNA polymerase III subunit RPC10, putative
21245 PF3D7_0923000 DNA-directed RNA polymerase II subunit RPB3 2.7.7.6
21289 PF3D7_1364300
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 3.6.4.13
21248 PF3D7_1010200 DNA2/NAM7 helicase, putative 3.6.4.12
21206 PF3D7_0215700 DNA-directed RNA polymerase II subunit RPB2 2.7.7.6
21276 DHX33 PF3D7_0310500 PF3D7_1227100
DNA helicase 60 3.6.4.12
21268 PF3D7_1202000
ATP-dependent DNA/RNA helicase PSH2 3.6.4.13
21215 PF3D7_0504400
ATP-dependent helicase, putative 3.6.1.3
21261 PF3D7_1106600 DEAD/DEAH box helicase, putative 3.6.4.13
21211 PF3D7_0317000 proteasome subunit alpha type-3, putative 3.4.25.1
21303 PF3D7_1445900
ATP-dependent RNA helicase ddx17 3.6.4.13
21218 PF3D7_0508700 pre-mRNA-processing ATP-dependent RNA helicase PRP5, putative 3.6.4.13
21214 PF3D7_0504200 ATP-dependent RNA helicase ddx27, putative 3.6.4.13
21201 PF3D7_0103600
ATP-dependent DNA/RNA helicase psh1 3.6.4.13
21233 PF3D7_0810600 ATP-dependent RNA helicase dbp1, putative 3.6.4.13
21208 PF3D7_0304700 conserved Plasmodium protein, unknown function
21225 PF3D7_0602100 ATP-dependent RNA helicase, mtr4 3.6.4.13
21230 PF3D7_0720000 exosome complex component CSL4, putative 3.1.13.1
21302 PF3D7_1445200 ATP-dependent RNA helicase MAK5, putative 3.6.4.13
21216 PF3D7_0507600 protein caf40, putative
21288 DDX60 PF3D7_0903400 PF3D7_1357700 U3 small nucleolar RNA-associated protein 21, putative
21224 PF3D7_0524000 karyopherin beta
21280 PF3D7_1308200
carbamoyl phosphate synthetase 6.3.5.5
21254 PF3D7_1020700 histone acetyltransferase, putative 2.3.1.1
21228 PF3D7_0703900 conserved Plasmodium membrane protein, unknown function
21303 PF3D7_1445900
ATP-dependent RNA helicase ddx17 3.6.4.13
21282 PF3D7_1317900 nucleolar complex protein 4, putative
21304 PF3D7_1448000 U3 small nucleolar RNA-associated protein 12, putative
21297 PF3D7_1420400
glycine--tRNA ligase 6.1.1.14
21287 PF3D7_1347200
nucleoside transporter 1, NT1
21305 PF3D7_1449700
exosome complex exonuclease RRP6 3.1.13.-
21285 PF3D7_1333600 U3 small nucleolar RNA-associated protein 4, putative
21249 PF3D7_1010600 eukaryotic translation initiation factor 2 subunit beta, putative
21272 PF3D7_1212700 eukaryotic translation initiation factor 3 subunit A, putative
21210 PF3D7_0315100
eukaryotic translation initiation factor 4E
21262 DDX2/  eIF4A PF3D7_1468700 PF3D7_1107300 polyadenylate-binding protein-interacting protein 1, putative
21231 PF3D7_0728000 eukaryotic translation initiation factor 2 subunit alpha, putative
21286 PF3D7_1342000 40S ribosomal protein S6
21293 PF3D7_1410600 eukaryotic translation initiation factor 2 subunit gamma, putative
21220 PF3D7_0517700 eukaryotic translation initiation factor 3 subunit B, putative
21247 PF3D7_1003500 40S ribosomal protein S20e, putative
29809 PF3D7_1224300
polyadenylate-binding protein 1, putative
21241 PF3D7_0918300 eukaryotic translation initiation factor 3 subunit F, putative
21235 PF3D7_0813900 40S ribosomal protein S16, putative
21270 PF3D7_1206700 eukaryotic translation initiation factor 5, putative
21207 PF3D7_0217800 40S ribosomal protein S26
21236 PF3D7_0815600 eukaryotic translation initiation factor 3 subunit G, putative
21309 PF3D7_1474900 trailer hitch homolog, putative
21281 PF3D7_1308900 mRNA-decapping enzyme 2, putative
21271 PF3D7_1209200 U6 snRNA-associated Sm-like protein LSm7, putative
21264 DDX6/  DOZI PF3D7_0320800 PF3D7_1124400 U6 snRNA-associated Sm-like protein LSm1, putative
21299 PF3D7_1435700 ataxin-2 like protein, putative
21256 PF3D7_1032100
mRNA-decapping enzyme subunit 1, putative
21234 PF3D7_0811300 CCR4-associated factor 1
21258 PF3D7_1103800 CCR4-NOT transcription complex subunit not1-g, putative
21295 PF3D7_1417200 CCR4-NOT transcription complex subunit not1, putative
21283 PF3D7_1325000 U6 snRNA-associated Sm-like protein LSm6, putative
21307 PF3D7_1459700 pyridoxal 5'-phosphate synthase, putative 1.4.3.5
21210 PF3D7_0315100
eukaryotic translation initiation factor 4E
29809 PF3D7_1224300
polyadenylate-binding protein 1, putative
21278 PF3D7_1235300 CCR4-NOT transcription complex subunit 4, putative
21260 PF3D7_1106300 5'-3' exoribonuclease 1, putative 3.1.4.1
The prediction of interacting proteins presented here was done using STRING 10 at http://string-db.org/. The cutoff score of 0.7 was used and only top fifteen interactors are listed in the table.
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