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Atovaquone - effect of drug on gene transcription |
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Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT. An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics. 2015 Dec 4;16:1030.PMID: 26637195 |
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Ratio = Transcript of treated vs untreated control |
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PfID |
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Annotation |
Ratio |
EC |
Transcript |
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| 39046 |
PF3D7_0622300 |
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vacuolar transporter chaperone, putative |
1.842 |
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| 39067 |
PF3D7_0936500 |
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virulence-associated protein 1 |
1.558 |
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| 39092 |
PF3D7_1253200 |
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hypothetical protein |
1.498 |
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| 39082 |
PF3D7_1135000 |
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PQ-loop repeat-containing protein |
1.460 |
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| 39116 |
PF3D7_0610300 |
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ncRNA |
1.460 |
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| 39044 |
PF3D7_0604200 |
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ribosomal protein l41, mitochondrial, putative |
1.449 |
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| 39071 |
PF3D7_1034700 |
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ADP-ribosylation factor, putative |
1.443 |
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| 39034 |
PF3D7_0414200 |
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calmodulin-like protein |
1.430 |
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| 39119 |
PF3D7_0702700 |
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tRNA Alanine |
1.414 |
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| 39118 |
PF3D7_0706800 |
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tRNA Threonine |
1.405 |
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| 39104 |
PF3D7_1417400 |
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rap guanine nucleotide exchange factor |
1.380 |
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| 39035 |
PF3D7_0416600 |
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prohibitin-like protein phbl, putative |
1.337 |
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| 39113 |
PF3D7_1478900 |
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ncRNA |
1.334 |
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| 39093 |
PF3D7_1253800 |
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Plasmodium exported protein (PHISTa), unknown function |
1.320 |
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| 39062 |
PF3D7_0833200 |
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rifin PIR protein |
1.315 |
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| 39110 |
PF3D7_0707000 |
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tRNA Lysine |
1.314 |
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| 39040 |
PF3D7_0528400 |
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palmitoyltransferase |
1.303 |
2.3.1.- |
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| 39114 |
PF3D7_0211000 |
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ncRNA |
1.300 |
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| 39111 |
PF3D7_0725700 |
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rRNA |
1.292 |
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| 39108 |
PF3D7_1474100 |
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ribosomal protein L20, mitochondrial, putative |
1.289 |
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| 39009 |
PF3D7_0102300 |
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Plasmodium exported protein, unknown function |
1.288 |
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| 39066 |
PF3D7_0917900 |
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PfHsp70-2 |
1.284 |
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| 39023 |
PF3D7_0300800 |
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rifin PIR protein |
1.282 |
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| 39099 |
PF3D7_1372800 |
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stevor PIR protein |
1.260 |
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| 39058 |
PF3D7_0832200 |
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Plasmodium exported protein (PHISTa-like), unknown function |
1.251 |
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| 39112 |
PF3D7_1463500 |
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fam-a protein |
1.246 |
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| 39051 |
PF3D7_0715500 |
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ATP synthase subunit epsilon, mitochondrial, putative |
1.246 |
3.6.3.14 |
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| 39014 |
PF3D7_0201400 |
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Plasmodium exported protein (hyp10), unknown function |
1.242 |
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| 39011 |
PF3D7_0112900 |
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Plasmodium exported protein, unknown function |
1.239 |
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| 39106 |
PF3D7_1453600 |
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RAP protein, putative |
1.234 |
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| 39016 |
PF3D7_0202200 |
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EMP1-trafficking protein |
1.233 |
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| 39117 |
PF3D7_0714700 |
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tRNA Asparagine |
1.233 |
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| 39081 |
PF3D7_1123700 |
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ribosomal protein l37, mitochondrial, putative |
1.232 |
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| 39080 |
PF3D7_1120900 |
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heat shock factor-binding protein 1 |
1.231 |
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| 39074 |
PF3D7_1037000 |
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DNA polymerase zeta catalytic subunit, putative |
1.228 |
2.7.7.7 |
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| 39069 |
PF3D7_1022900 |
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COX13 CDGSH iron-sulfur domain-containing protein, putative |
1.225 |
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| 39083 |
PF3D7_1138100 |
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ubiquitin-related modifier 1, putative |
1.222 |
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| 39107 |
PF3D7_1455400 |
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hemolysin III |
1.222 |
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| 39105 |
PF3D7_1441700 |
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mitochondrial inner membrane protease atp23, putative |
1.222 |
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| 39057 |
PF3D7_0831900 |
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Plasmodium exported protein (PHIST), unknown function, pseudogene |
1.220 |
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| 39015 |
PF3D7_0201800 |
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knob associated heat shock protein 40 |
1.220 |
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| 39097 |
PF3D7_1359800 |
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ADP-ribosylation factor, putative |
1.220 |
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| 39091 |
PF3D7_1252600 |
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esterase, putative |
1.219 |
3.1.1.5 |
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| 39061 |
PF3D7_0832900 |
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stevor PIR protein |
0.735 |
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| 39018 |
PF3D7_0208900 |
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6-cysteine protein |
0.732 |
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| 39079 |
PF3D7_1101900 |
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erythrocyte membrane protein 1 (PFEMP1), pseudogene |
0.730 |
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| 39021 |
PF3D7_0221900 |
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erythrocyte membrane protein 1 (PfEMP1), pseudogene |
0.730 |
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| 39037 |
PF3D7_0421600 |
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erythrocyte membrane protein 1 (PfEMP1)-like pseudogene |
0.729 |
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| 39073 |
PF3D7_1036300 |
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merozoite surface protein |
0.726 |
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| 39096 |
PF3D7_1340000 |
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secreted ookinete protein, putative |
0.725 |
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| 39094 |
PF3D7_1254200 |
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rifin |
0.725 |
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| 39041 |
PF3D7_0600800 |
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rifin, pseudogene |
0.725 |
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| 39042 |
PF3D7_0601400 |
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erythrocyte membrane protein 1 (PfEMP1), pseudogene |
0.725 |
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| 39101 |
PF3D7_1373300 |
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PIR protein rifin |
0.725 |
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| 39053 |
PF3D7_0732100 |
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erythrocyte membrane protein 1 (PfEMP1), pseudogene |
0.725 |
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| 39100 |
PF3D7_1373100 |
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PIR protein rifin |
0.723 |
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| 39070 |
PF3D7_1034300 |
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thioredoxin-like associated protein 2, putative |
0.722 |
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| 39012 |
PF3D7_0114700 |
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rifin PIR protein |
0.720 |
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| 39043 |
PF3D7_0601700 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
0.718 |
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| 39030 |
PF3D7_0401300 |
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rifin |
0.718 |
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| 39102 |
PF3D7_1400100 |
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erythrocyte membrane protein 1 (PfEMP1), truncated, pseudogene |
0.718 |
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| 39031 |
PF3D7_0402700 |
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rifin, pseudogene |
0.718 |
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| 39084 |
PF3D7_1149700 |
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Plasmodium exported protein (PHISTa), unknown function |
0.717 |
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| 39010 |
PF3D7_0104700 |
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apicomplexan amino acid transporter apiat9, putative |
0.716 |
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| 39089 |
PF3D7_1240600 |
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erythrocyte membrane protein 1, PfEMP1 |
0.716 |
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| 39055 |
PF3D7_0815900 |
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dihydrolipoyl dehydrogenase, apicoplast |
0.714 |
1.1.1.35 |
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| 39085 |
PF3D7_1150300 |
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rifin |
0.713 |
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| 39013 |
PF3D7_0115700 |
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erythrocyte membrane protein 1, PfEMP1 |
0.712 |
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| 39049 |
PF3D7_0712500 |
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rifin, pseudogene |
0.712 |
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| 39022 |
PF3D7_0223500 |
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erythrocyte membrane protein 1, PfEMP1 |
0.712 |
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| 39052 |
PF3D7_0731900 |
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rifin, pseudogene |
0.711 |
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| 39056 |
PF3D7_0823400 |
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alpha/beta hydrolase, putative |
0.705 |
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| 39115 |
PF3D7_0403000 |
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tRNA Asparagine |
0.705 |
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| 39020 |
PF3D7_0221500 |
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Pfmc-2TM Maurer's cleft two transmembrane protein, pseudogene |
0.704 |
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| 39019 |
PF3D7_0221000 |
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Plasmodium exported protein, unknown function |
0.702 |
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| 39039 |
PF3D7_0425600 |
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rifin, pseudogene |
0.700 |
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| 39077 |
PF3D7_1040400 |
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rifin |
0.700 |
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| 39068 |
PF3D7_1000100 |
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erythrocyte membrane protein 1, PfEMP1 |
0.699 |
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| 39038 |
PF3D7_0425300 |
|
|
Plasmodium exported protein (PHISTa), unknown function, pseudogene |
0.699 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39024 |
PF3D7_0304000 |
|
|
inner membrane complex protein 1a, putative |
0.699 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39072 |
PF3D7_1035600 |
|
|
merozoite surface protein |
0.699 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39017 |
PF3D7_0207900 |
|
|
serine repeat antigen 2 |
0.698 |
3.4.22.- |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39047 |
PF3D7_0700200 |
|
|
PIR protein rifin |
0.698 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39026 |
PF3D7_0312900 |
|
|
hypothetical protein |
0.696 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39076 |
PF3D7_1039400 |
|
|
erythrocyte membrane protein 1 (PfEMP1), pseudogene |
0.695 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39025 |
PF3D7_0305800 |
|
|
P-loop containing nucleoside triphosphate hydrolase, putative |
0.694 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39031 |
PF3D7_0402700 |
|
|
rifin, pseudogene |
0.693 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39063 |
PF3D7_0900800 |
|
|
erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene |
0.692 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39027 |
PF3D7_0315200 |
|
|
circumsporozoite- and TRAP-related protein |
0.691 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39086 |
PF3D7_1211100 |
|
|
HSP20-like chaperone |
0.691 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39065 |
PF3D7_0901600 |
|
|
PIR protein stevor |
0.690 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39064 |
PF3D7_0901100 |
|
|
rifin |
0.687 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39045 |
PF3D7_0616500 |
|
|
TRAP-like protein |
0.677 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39054 |
PF3D7_0808800 |
|
|
PIR protein rifin |
0.676 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39109 |
PF3D7_1479600 |
|
|
PIR protein rifin |
0.673 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39060 |
PF3D7_0832800 |
|
|
PIR protein rifin |
0.670 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39103 |
PF3D7_1400800 |
|
|
rifin PIR protein |
0.667 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39087 |
PF3D7_1219200 |
|
|
rifin, pseudogene |
0.666 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39032 |
PF3D7_0402800 |
|
|
erythrocyte membrane protein 1 (PfEMP1), pseudogene |
0.663 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39088 |
PF3D7_1240200 |
|
|
erythrocyte membrane protein 1 (PfEMP1), pseudogene |
0.663 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39033 |
PF3D7_0413300 |
|
|
rifin |
0.662 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39075 |
PF3D7_1039100 |
|
|
DnaJ protein, putative, pseudogene? MEC domain-containing protein |
0.652 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39078 |
PF3D7_1041300 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.647 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39008 |
PF3D7_0100800 |
|
|
PIR protein rifin |
0.647 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39050 |
PF3D7_0712800 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.638 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39029 |
PF3D7_0400900 |
|
|
rifin |
0.624 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39098 |
PF3D7_1367800 |
|
|
secreted ookinete protein, putative |
0.623 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39059 |
PF3D7_0832600 |
|
|
stevor PIR protein |
0.623 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39036 |
PF3D7_0421100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.609 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39090 |
PF3D7_1240700 |
|
|
rifin, pseudogene |
0.584 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39028 |
PF3D7_0324500 |
|
|
rifin |
0.563 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39048 |
PF3D7_0700800 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
0.524 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39095 |
PF3D7_1254300 |
|
|
PIR protein stevor |
0.511 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|