Divergent composition of the respiratory chain complexes
Evers F, Cabrera-Orefice A, Elurbe DM, Kea-Te Lindert M, Boltryk SD, Voss TS, Huynen MA, Brandt U, Kooij TWA. Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum. Nat Commun. 2021 12(1):3820. PMID: 34155201
ETC Complex Name Gene ID Annotation Mol. Massa EC# Transcript
        CII
 SDHA PF3D7_1034400
flavoprotein subunit of succinate dehydrogenase 70.7 1.3.5.1
SDHB PF3D7_1212800
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 378 1.3.99.1
PfSDHC PF3D7_1448900 mitochondrial respiratory chain complex ii subunit, putative 8.9
C2AP1 PF3D7_0808450 protein MPODD, putative 10.6
C2AP2 PF3D7_1322800 mitochondrial respiratory chain complex ii subunit, putative 14
C2AP3 PF3D7_0109950 mitochondrial respiratory chain complex ii subunit, putative 19.5
C2AP4 PF3D7_1346600 mitochondrial respiratory chain complex ii subunit, putative 26.7
Monomer 188
Trimer 564
CIII
 Cytb PF3D7_MIT02300 cytochrome b 43.4
Cytc1 PF3D7_1462700
cytochrome c1, heme protein, mitochondrial, putative 46.1
Rieske PF3D7_1439400
cytochrome b-c1 complex subunit Rieske, putative 41 1.10.2.2
QCR6 PF3D7_1426900
cytochrome b-c1 complex subunit 6, putative 11 1.10.2.2
QCR7 PF3D7_1012300
cytochrome b-c1 complex subunit 7, putative 23 1.10.2.2
QCR8 PF3D7_0306000 cytochrome b-c1 complex subunit 8, putative 17
QCR9 PF3D7_0622600
cytochrome b-c1 complex subunit 9, putative 11.7 1.10.2.2
MPPalpha PF3D7_0933600
cytochrome b-c1 complex subunit 1, putative 55.7 3.4.24.64
MPPbeta PF3D7_0523100 cytochrome b-c1 complex subunit 2, putative 61.8 3.4.24.64
C3AP1 PF3D7_0722700 cytochrome b-c1 complex subunit 11, putative 9.5
C3AP2 PF3D7_1326000 cytochrome b-c1 complex subunit 12, putative 19.3
C3AP3 PF3D7_0817800 conserved Plasmodium protein, unknown function 6.2
Dimer 690
CIV
 COX1 mal_mito_2 COX 1 cytochrome c oxidase subunit I 57 1.9.3.1
COX2a PF3D7_1361700 cytochrome c oxidase subunit 2a, putative 27.3 1.9.3.1
COX2b PF3D7_1430900 cytochrome c oxidase subunit 2b, putative 19.8 1.9.3.1
COX3 mal_mito_1
COX3 cytochrome c oxidase subunit 3 32.3 1.9.3.1
PfCOX4 PF3D7_0708700 Cox23 27.6
COX5b PF3D7_0927800 COX5B cytochrome c oxidase subunit 5B, putative 32.4 1.9.3.1
PfCOX6a PF3D7_1465000 cytochrome c oxidase subunit apicox25, putative 33.3 1.9.3.1
COX6b PF3D7_0928000 COX6b cytochrome c oxidase subunit 6B, putative 12.2 1.9.3.1
PfCOX6c PF3D7_0306500 cytochrome c oxidase subunit apicox35, putative 36.4
PfNDUFA4 PF3D7_1439600 COX26 22.6
ApiCOX13 PF3D7_1022900 COX13 CDGSH iron-sulfur domain-containing protein, putative 13.9
ApiCOX14 PF3D7_1339400 COX14 cytochrome c oxidase subunit apicox14, putative 17.8
ApiCOX16 PF3D7_1345300 conserved Plasmodium protein, unknown function 10.2
ApiCOX18 PF3D7_0523300 COX18 cytochrome c oxidase subunit apicox18, putative 16
ApiCOX19 PF3D7_1402200 cytochrome c oxidase subunit apicox19, putative 22.1
ApiCOX24 PF3D7_1362000 COX24 23.8
ApiCOX30 PF3D7_0915700 COX30 22.4
C4AP1 PF3D7_1125600 conserved Plasmodium protein, unknown function 10
C4AP2 PF3D7_1025800 conserved Plasmodium protein, unknown function 8.2
C4AP3 PF3D7_1003100 conserved Plasmodium protein, unknown function 10.7
C4AP4 PF3D7_0608400 conserved Plasmodium protein, unknown function 12.7
C4AP5 PF3D7_0809250 conserved Plasmodium protein, unknown function 7.9
Monomer 476
 CV
 OSCP PF3D7_1310000
ATP synthase subunit o, mitochondrial, putative 30.2 3.6.3.14
ATPα PF3D7_0217100
ATP synthase subunit alpha, mitochondrial 61.8 3.6.3.14
ATPβ PF3D7_1235700
ATP synthase subunit beta, mitochondrial 58.4 3.6.3.14
ATPγ PF3D7_1311300
ATP synthase subunit gamma, mitochondrial 35.8 3.6.3.14
ATPd PF3D7_0311800 ATP synthase F0 subunit d-like protein, putative 73.5
ATPb PF3D7_1125100 ATP synthase F0 subunit b-like protein 59.3
ATPk PF3D7_0107400 ATP synthase-associated protein, putative 18.8
ATP i/j PF3D7_1360000 ATP synthase-associated protein, putative 21.6
ATPδ PF3D7_1147700
ATP synthase subunit delta, mitochondrial, putative 17.6 3.6.3.14
ATPε PF3D7_0715500
ATP synthase subunit epsilon, mitochondrial, putative 8.5 3.6.3.14
ATPag PF3D7_0719100 ATP synthase F0 subunit a-like protein 21.3
ATPcg PF3D7_0705900
ATP synthase subunit C, putative 18.6 3.6.3.14
ATP8 PF3D7_0934300 ATP synthase-associated protein 16.9
ATPTG2 PF3D7_0611300 ATP synthase-associated protein, putative 33.5
ATPTG3 PF3D7_0815400 ATP synthase-associated protein, putative 18.8
ATPTG4 PF3D7_0905000 conserved Plasmodium protein, unknown function 34
ATPTG6 PF3D7_1142800 ATP synthase-associated protein 35.5
ATPTG9 PF3D7_1417900 cleavage and polyadenylation specificity factor subunit 4, putative 16.8
ATPTG10 PF3D7_1024300 ATP synthase-associated protein 15.6
ATPTG12 PF3D7_0620100 ATP synthase-associated protein 15.5
ATPTG13 PF3D7_1303000 ATP synthase-associated protein, putative 13.8
ATPTG15 PF3D7_0825400 conserved apicomplexan protein, unknown function 14.2
ATPTG17 PF3D7_0306600 ATP synthase-associated protein, putative 9.9
Monomer 1076
Dimer 2152
a InkDa; estimates based on predicted amino acid composition, no post-translational modifications, cleavage events or lipid association were assumed. For complex mass estimation standard stoichiometry for conserved components (10× ATPc per CV monomer) and
b Based on all samples.
c Mean fitness scores as an indicator of P. falciparum gene essentiality.
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