|
Post-translational modifications identified of histones |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Saraf A, Cervantes S, Bunnik EM, Ponts N, Sardiu ME, Chung DD, Prudhomme J, Varberg JM, Wen Z, Washburn MP, Florens L, Le Roch KG. Dynamic and Combinatorial Landscape of Histone Modifications during the Intraerythrocytic Developmental Cycle of the Malaria Parasite. J Proteome Res. 2016 15(8):2787-801. PMID: 27291344. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Abbreviations: NTac, N-terminal acetylation; ac, acetylation; me1, monomethylation; me2, dimethylation; me3, trimethylation; fo, formylation; phs, phosphorylation; ub, ubiquitination; oh, hydroxylation; n.c., amino acid residue not conserved; cr, crotonylation; amino acid residue not conserved; n.d., amino acid not detected as modified in this study; n.r., non-redundant count of PTMs undistinguishable between H3/H3.3 isoforms. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 25112 |
H2A
|
PF3D7_0617800 |
|
|
Histone-Residue Position Modification |
PTM Type |
PTM Location |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H2A-NTacS1 |
NTac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2 |
|
|
|
H2A-K3ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
H2A-K5ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
H2A-K9ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H2A-K10ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H2A-K20ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H2A-K20fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
7 |
|
|
|
H2A-R29me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H2A-K41fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H2A-R42fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10 |
|
|
|
H2A-P48oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2A-Y50oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12 |
|
|
|
H2A-Y57oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
13 |
|
|
|
H2A-R71me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
14 |
|
|
|
H2A-K75me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H2A-K95ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H2A-K95fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H2A-T101ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
17 |
|
|
|
H2A-K118me1 |
me1 |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
17 |
|
|
|
H2A-K118oh |
oh |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H2A-S120phs |
phs |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
19 |
|
|
|
H2A-T126phs |
phs |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-S1phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K3me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K3me3 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K9me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K9me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K13ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-S16phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-S18phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K36ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K36fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K36cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-Y39oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-R42me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K74ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-R77me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-R77me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-T79ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-R88me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K95me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K95me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K95cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K118fo |
fo |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K118cr |
cr |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K119ac |
Kac |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K119me1 |
me1 |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K119ub |
ub |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2A-K119cr |
cr |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 25110 |
H2A.Z
|
PF3D7_0320900 |
|
|
Histone-Residue Position Modification |
PTM Type |
PTM Location |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H2Az-M1NTac/ac-ox |
NTac+ox |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2 |
|
|
|
H2Az-K6ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
H2Az-K11ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
H2Az-K15ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H2Az-K19ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H2Az-K25ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
7 |
|
|
|
H2Az-K28ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H2Az-K30ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H2Az-K35ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10 |
|
|
|
H2Az-Y77oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2Az-R115fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12 |
|
|
|
H2Az-H138oh |
oh |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
13 |
|
|
|
H2Az-K139oh |
oh |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H2Az-M142ox |
ox |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Az-S33phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Az-K37ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Az-K38ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 25116 |
H2B
|
PF3D7_1105100 |
|
|
Histone-Residue Position Modification |
PTM Type |
PTM Location |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H2B-K3ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2 |
|
|
|
H2B-K7ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
H2B-S24ac |
STac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
H2B-R25fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H2B-S28ac |
STac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H2B-Y29oh |
oh |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
7 |
|
|
|
H2B-Y32oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H2B-K35ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H2B-K35fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H2B-K35me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H2B-K35me3 |
me3 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H2B-K35oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H2B-K38ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H2B-K38fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H2B-K38me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H2B-K38oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10 |
|
|
|
H2B-P42oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2B-K49ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2B-K49cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2B-K49fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2B-K49me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2B-K49me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2B-K49me3 |
me3 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2B-K49oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12 |
|
|
|
H2B-S50ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12 |
|
|
|
H2B-S50phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
13 |
|
|
|
H2B-S56phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
14 |
|
|
|
H2B-D60oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H2B-T61ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H2B-K64ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H2B-K64fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H2B-K64me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H2B-K64me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H2B-K64me3 |
me3 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H2B-K64oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
17 |
|
|
|
H2B-R71me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H2B-R91me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
19 |
|
|
|
H2B-P95oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
20 |
|
|
|
H2B-K100fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
20 |
|
|
|
H2B-K100oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
21 |
|
|
|
H2B-K108fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
21 |
|
|
|
H2B-K108me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
22 |
|
|
|
H2B-K112fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
22 |
|
|
|
H2B-K112ub |
ub |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H2B-M51ox |
ox |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H2B-M54ox |
ox |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K3fo/H2Bv-K3fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K3cr/H2Bv-K3cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K4ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K7cr/H2Bv-K8cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K9ac |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K9me1/H2Bv-K13me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K9cr/H2Bv-K13cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K10ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K10cr/H2Bv-K14cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-S24phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-S28phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-Y29phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-T67phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-Y75phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-R77me1/H2Bv-K81me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-T80phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K100ac/H2Bv-K104ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K100me1/H2Bv-K104me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K100cr/H2Bv-K104cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-S104phs/H2Bv-S108phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-S104ac/H2Bv-S108ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K108ac/H2Bv-K112ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K112ac/H2Bv-K116ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 25114 |
H2B.Z
|
PF3D7_0714000 |
|
|
Histone-Residue Position Modification |
PTM Type |
PTM Location |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H2Bv-NTacS1 |
NTac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2 |
|
|
|
H2Bv-K3ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
H2Bv-K8ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
H2Bv-K13ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H2Bv-K14ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H2Bv-K18ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
7 |
|
|
|
H2Bv-R29fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H2Bv-T30ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H2Bv-K39fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10 |
|
|
|
H2Bv-K42ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10 |
|
|
|
H2Bv-K42fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2Bv-K53ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2Bv-K53fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2Bv-K53me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H2Bv-K53oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12 |
|
|
|
H2Bv-S54ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
13 |
|
|
|
H2Bv-D64oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
14 |
|
|
|
H2Bv-D67oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H2Bv-R95fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H2Bv-R95me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H2Bv-K104fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
17 |
|
|
|
H2Bv-K112fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
17 |
|
|
|
H2Bv-K112me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H2Bv-K116fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H2Bv-K116ub |
ub |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H2Bv-M55ox |
ox |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H2Bv-M58ox |
ox |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-S1phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K3fo/H2Bv-K3fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K3cr/H2Bv-K3cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K7cr/H2Bv-K8cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K9me1/H2Bv-K13me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K9cr/H2Bv-K13cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K10cr/H2Bv-K14cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-K18me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-K18ub |
ub |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-K18cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-S32phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-K39me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-K42me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-K53me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-T71phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-R75me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-K81ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-R77me1/H2Bv-K81me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2Bv-T84phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K100ac/H2Bv-K104ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K100me1/H2Bv-K104me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K100cr/H2Bv-K104cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-S104phs/H2Bv-S108phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-S104ac/H2Bv-S108ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K108ac/H2Bv-K112ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H2B-K112ac/H2Bv-K116ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 25111 |
H3
|
PF3D7_0610400 |
|
|
Histone-Residue Position Modification |
PTM Type |
PTM Location |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H3-K9ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H3-K9me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H3-K9me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H3-K9me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H3-K9cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2 |
|
|
|
H3-S10ac |
STac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
H3-K14ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
H3-K14fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
H3-K14me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
H3-R17me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
H3-R17me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H3-K18ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H3/H3.3-K18cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H3/H3.3-K18fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H3-K18me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H3-S22ac |
STac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
7 |
|
|
|
H3/H3.3-K23ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H3-K27ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H3-K27me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H3-K27cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H3-K27fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H3-S28ac |
STac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H3-S28phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10 |
|
|
|
H3-S32phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H3-K36ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H3-K36fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H3-K36me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H3-K36me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12 |
|
|
|
H3/H3.3-R42me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12 |
|
|
|
H3/H3.3-R42fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
13 |
|
|
|
H3-R53fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
14 |
|
|
|
H3-Y54oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H3-K56ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H3-K56fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H3-R72fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
17 |
|
|
|
H3-Y78phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H3-K79ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H3-K79fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H3-K79me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H3-K79me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H3-K79me3 |
me3 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H3-K79oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
19 |
|
|
|
H3-T80phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
20 |
|
|
|
H3-R83fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
20 |
|
|
|
H3-R83me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
21 |
|
|
|
H3-Y99phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
22 |
|
|
|
H3-D106oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
23 |
|
|
|
H3-T107ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
23 |
|
|
|
H3-T107phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
24 |
|
|
|
H3-H113oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
25 |
|
|
|
H3-K115ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
25 |
|
|
|
H3-K115cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
25 |
|
|
|
H3-K115me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
25 |
|
|
|
H3-K115me3 |
me3 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
25 |
|
|
|
H3-K115oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26 |
|
|
|
H3/H3.3-R116fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
27 |
|
|
|
H3/H3.3-P121oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
28 |
|
|
|
H3/H3.3-K122ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
28 |
|
|
|
H3/H3.3-K122fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
28 |
|
|
|
H3/H3.3-K122me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H3-M90ox |
ox |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H3/H3.3-M120ox |
ox |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R2me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T3phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K4ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K4me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K4me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K4me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K4cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T6phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R8me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R8me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-S10phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T11phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K14me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K14me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-S22phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K23me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K23fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K23cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R26me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K27me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3-K27me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K36me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3-K37me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3-R40me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-Y41phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T45phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K56me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K56me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K56me3 |
me3 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K56cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-S57phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R63me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K64ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K64me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K64fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K79cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T80ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R83me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-S86phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K115ub |
ub |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T118phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K122cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R128me1 |
me1 |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R134me1 |
me1 |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 25113 |
H3.3
|
PF3D7_0617900 |
|
|
Histone-Residue Position Modification |
PTM Type |
PTM Location |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H3.3-K9ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H3.3-K9cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H3.3-K9me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H3.3-K9me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2 |
|
|
|
H3.3-S10ac |
STac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
H3.3-T11ac |
STac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
H3.3-K14ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H3.3-R17me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H3.3-R17me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H3.3-K18ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H3/H3.3-K18cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H3/H3.3-K18fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H3.3-K18me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
7 |
|
|
|
H3.3-S22ac |
STac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H3/H3.3-K23ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H3.3-K27ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H3.3-K27me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10 |
|
|
|
H3.3-S28phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H3.3-S32phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12 |
|
|
|
H3.3-K36ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12 |
|
|
|
H3.3-K36fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
13 |
|
|
|
H3.3-K37me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
14 |
|
|
|
H3.3-R40me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H3/H3.3-R42fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H3/H3.3-R42me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H3.3-K53fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H3.3-K53oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
17 |
|
|
|
H3.3-K56fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H3.3-R72fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
19 |
|
|
|
H3.3-K79fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
20 |
|
|
|
H3.3-S86ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
21 |
|
|
|
H3.3-Y99oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
22 |
|
|
|
H3.3-D106oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
23 |
|
|
|
H3.3-H113oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
25 |
|
|
|
H3.3-K115cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
25 |
|
|
|
H3.3-K115oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
25 |
|
|
|
H3/H3.3-R116fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26 |
|
|
|
H3/H3.3-P121oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
27 |
|
|
|
H3/H3.3-K122ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
27 |
|
|
|
H3/H3.3-K122fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
27 |
|
|
|
H3/H3.3-K122me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H3/H3.3-M120ox |
ox |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R2me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T3phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K4ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K4me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K4me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K4me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K4cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T6phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R8me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R8me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K9me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-S10phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T11phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K14me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K14me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K14me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-S22phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K23me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K23fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K23cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R26me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K27me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K27me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K27cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K36me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K36me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K36me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-Y41phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T45phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K56ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K56me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K56me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K56me3 |
me3 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K56cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-S57phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R63me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K64ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K64me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K64fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K79ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K79me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K79me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K79me3 |
me3 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K79cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-T80phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T80ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-R83me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R83me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-S86phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-T107phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3.3-K115ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K115ub |
ub |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-T118phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-K122cr |
cr |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R128me1 |
me1 |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H3/H3.3-R134me1 |
me1 |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 25117 |
H3.c
|
PF3D7_1333700 |
|
|
Histone-Residue Position Modification |
PTM Type |
PTM Location |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H3.c-K23ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2 |
|
|
|
H3.c-K26ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
H3.c-K60ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
H3.c-R108fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H3.c-M155ox |
ox |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 25115 |
H4
|
PF3D7_1105000 |
|
|
Histone-Residue Position Modification |
PTM Type |
PTM Location |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
|
H4-NTacS1 |
NTac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2 |
|
|
|
H4-R3me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
H4-K5ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
H4-K8ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
|
|
|
H4-K12ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
H4-K16ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
7 |
|
|
|
H4-K20ac |
Kac |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H4-K31ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
H4-K31fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
H4-R35me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10 |
|
|
|
H4-R45fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
H4-S47ac |
STac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12 |
|
|
|
H4-Y51oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
13 |
|
|
|
H4-R55me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
14 |
|
|
|
H4-K59fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H4-K67ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H4-K67fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H4-K67me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
H4-K67me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
H4-D68oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
17 |
|
|
|
H4-Y72oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H4-K77ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H4-K77me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
H4-K77oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
19 |
|
|
|
H4-K79ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
19 |
|
|
|
H4-K79fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
19 |
|
|
|
H4-K79me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
19 |
|
|
|
H4-K79me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
20 |
|
|
|
H4-D85oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
21 |
|
|
|
H4-Y88oh |
oh |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
22 |
|
|
|
H4-K91ac |
Kac |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
22 |
|
|
|
H4-K91fo |
fo |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
22 |
|
|
|
H4-K91me1 |
me1 |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H4-M71ox |
ox |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
X |
|
|
|
H4-M84ox |
ox |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-S1phs |
phs |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-R3me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K5me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K5me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K5cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K8cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K12me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K12fo |
fo |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K12cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K16me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K16me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K16cr |
cr |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-R17me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-R17me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-R19me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-R19me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K20me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K20me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K20me3 |
me3 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-R23me1 |
me1 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-R23me2 |
me2 |
NT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K31me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-S47phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-Y51phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K59ac |
Kac |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K59me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K59me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K77fo |
fo |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-R78me1 |
me1 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-R78me2 |
me2 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K79me3 |
me3 |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-T80phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-T82phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-Y88phs |
phs |
CD |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K91ub |
cr |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-K91cr |
cr |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
n.d. |
|
|
|
H4-R92me1 |
me1 |
CT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|