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Genes differentially expressed in severe malaria |
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Tonkin-Hill GQ, Trianty L, Noviyanti R, Nguyen HHT, Sebayang BF, Lampah DA, Marfurt J, Cobbold SA, Rambhatla JS, McConville MJ, Rogerson SJ, Brown GV, Day KP, Price RN, Anstey NM, Papenfuss AT, Duffy MF. The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding genes. PLoS Biol. 2018 Mar 12;16 :e2004328. PMID: 29529020; |
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Fold change = gene expression in severe malaria compared to uncomplicated malaria |
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PfID |
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Annotation |
Fold change |
EC# |
Transcript |
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| 29460 |
PF3D7_1372100 |
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Plasmodium exported protein (PHISTb), unknown function gametocyte exported protein 4 |
8.75 |
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| 29293 |
PF3D7_0423800 |
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RH5-Ripr membrane anchoring protein cysteine-rich protective antigen |
4.89 |
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| 29369 |
PF3D7_0925300 |
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proline--tRNA ligase, putative |
4.31 |
6.1.1.15 |
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| 29487 |
PF3D7_1477700 |
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Plasmodium exported protein (PHISTa), unknown function |
4.26 |
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| 29450 |
PF3D7_1346200 |
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nuclear import protein MOG1, putative |
4.01 |
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| 29385 |
PF3D7_1100300 |
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rifin |
3.98 |
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| 29280 |
PF3D7_0404900 |
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6-cysteine protein |
3.74 |
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| 29474 |
PF3D7_1437800 |
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41-2 protein antigen precursor trafficking protein particle complex subunit 5, putative |
3.41 |
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| 29455 |
PF3D7_1355200 |
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RAP protein, putative |
3.10 |
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| 29358 |
PF3D7_0830300 |
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sporozoite invasion-associated protein 2 |
3.01 |
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| 29316 |
PF3D7_0606800 |
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VFT protein |
2.93 |
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| 29417 |
PF3D7_1226600 |
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proliferating cell nuclear antigen 2 |
2.82 |
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| 29386 |
PF3D7_1102600 |
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gametocyte exported protein 14 Plasmodium exported protein, unknown function |
2.75 |
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| 38969 |
PF3D7_1321600 |
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cGMP-specific 3',5'-cyclic phosphodiesterase gamma, putative |
2.64 |
3.1.4.17 |
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| 29456 |
PF3D7_1355700 |
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NLI interacting factor-like phosphatase, putative |
2.36 |
3.1.3.16 |
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| 29409 |
PF3D7_1205700 |
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targeted glyoxalase II |
2.34 |
3.1.2.6 |
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| 29315 |
PF3D7_0601600 |
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tetratricopeptide repeat protein, putative |
2.34 |
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| 29389 |
PF3D7_1103400 |
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sulfur cluster assembly protein SufD |
2.29 |
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| 29376 |
PF3D7_1015800 |
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ribonucleoside-diphosphate reductase small chain, putative |
2.29 |
1.17.4.1 |
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| 29320 |
PF3D7_0613900 |
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myosin E, putative |
2.28 |
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| 29338 |
PF3D7_0713600 |
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ribosomal protein S5, mitochondrial, putative |
2.24 |
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| 29375 |
PF3D7_1013000 |
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zinc finger protein, putative |
2.20 |
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| 29471 |
PF3D7_1431600 |
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succinyl-CoA ligase [ADP-forming] subunit beta |
2.17 |
6.2.1.5 |
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| 29368 |
PF3D7_0923100 |
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OTU-like cysteine protease, putative |
2.16 |
3.4.22.- |
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| 29405 |
PF3D7_1145500 |
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ABC transporter B family member 3, putative. ABCB3 |
2.15 |
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| 29459 |
PF3D7_1366500 |
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nucleoside diphosphate kinase |
2.13 |
2.7.4.6 |
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| 29449 |
PF3D7_1345200 |
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rhomboid protease ROM6, putative |
2.12 |
3.4.21.105 |
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| 29402 |
PF3D7_1126300 |
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DnaJ protein, putative |
2.10 |
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| 29396 |
PF3D7_1118400 |
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haloacid dehalogenase-like hydrolase, putative |
2.09 |
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| 29473 |
PF3D7_1436500 |
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GTP-binding protein, putative |
2.08 |
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| 29353 |
PF3D7_0817100 |
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tRNA modification GTPase, putative |
2.06 |
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| 29426 |
PF3D7_1244200 |
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RNA polymerase II transcription factor B subunit 2, putative |
2.04 |
2.7.7.6 |
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| 29411 |
PF3D7_1212800 |
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succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
2.03 |
1.3.99.1 |
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| 29269 |
PF3D7_0303400 |
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palmitoyltransferase |
2.00 |
2.3.1.- |
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| 29470 |
PF3D7_1428100 |
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WW domain-binding protein 11, putative |
1.95 |
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| 29270 |
PF3D7_0305000 |
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elongation factor Ts |
1.93 |
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| 29347 |
PF3D7_0804900 |
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GTPase-activating protein, putative |
1.89 |
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| 29418 |
PF3D7_1230500 |
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WD repeat-containing protein, putative |
1.88 |
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| 29308 |
PF3D7_0524800 |
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ubiquitin fusion degradation protein 1, putative |
1.84 |
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| 29341 |
PF3D7_0724000 |
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Rab GTPase activator and protein kinase, putative |
1.83 |
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| 29273 |
PF3D7_0317100 |
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6-cysteine protein |
1.83 |
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| 29401 |
PF3D7_1126100 |
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autophagy-related protein 7, putative |
1.81 |
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| 29377 |
PF3D7_1019300 |
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zinc finger protein, putative |
1.79 |
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| 29394 |
PF3D7_1111300 |
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protein transport protein BOS1, putative |
1.79 |
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| 29323 |
PF3D7_0625600 |
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poly(A) polymerase PAP, putative |
1.79 |
2.7.7.19 |
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| 29328 |
PF3D7_0705600 |
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RNA helicase, putative |
1.78 |
3.6.4.13 |
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| 29354 |
PF3D7_0821500 |
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ribosomal RNA small subunit methyltransferase NEP1, putative |
1.77 |
2.1.1.260 |
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| 29319 |
PF3D7_0612700 |
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6-cysteine protein p12 |
1.76 |
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| 29321 |
PF3D7_0614200 |
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cytosolic Fe-S cluster assembly factor NAR1, putative |
1.76 |
1.12.7.2 |
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| 29484 |
PF3D7_1459300 |
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OPA3-like protein, putative |
1.74 |
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| 29264 |
PF3D7_0216400 |
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vacuolar protein sorting-associated protein 45, putative |
1.73 |
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| 29453 |
PF3D7_1353500 |
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RNA polymerase II transcription factor B subunit 4, putative |
1.71 |
2.7.7.6 |
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| 29348 |
PF3D7_0805600 |
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phosphatidic acid phosphatase 2; phospholipid phosphatase pap2 |
1.71 |
3.1.3.4 |
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| 29479 |
PF3D7_1450300 |
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NADPH--cytochrome P450 reductase, putative |
1.70 |
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| 29478 |
PF3D7_1446900 |
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glutaminyl-peptide cyclotransferase, putative |
1.70 |
2.3.2.5 |
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| 29392 |
PF3D7_1108700 |
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heat shock protein 40, type ii |
1.68 |
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| 29413 |
PF3D7_1215900 |
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serpentine receptor 10, PfSr10 |
1.67 |
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| 29759 |
PF3D7_1365600 |
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DNA topoisomerase 6 subunit b, putative |
1.66 |
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| 29441 |
PF3D7_1309600 |
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ribosomal RNA methyltransferase, putative |
1.66 |
2.1.1.56 |
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| 29362 |
PF3D7_0903100 |
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protein RER1, putative |
1.62 |
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| 29477 |
PF3D7_1445600 |
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RNA-binding protein, putative |
1.60 |
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| 29290 |
PF3D7_0419800 |
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60S ribosomal protein L7ae/L30e, putative |
1.56 |
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| 29431 |
PF3D7_1253100 |
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Plasmodium exported protein (PHISTa), unknown function |
1.53 |
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| 29404 |
PF3D7_1142400 |
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coproporphyrinogen-III oxidase HemF |
1.51 |
1.3.3.3 |
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| 29274 |
PF3D7_0317500 |
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kinesin-5 |
1.50 |
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| 29393 |
PF3D7_1111000 |
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RNA cytosine c(5)-methyltransferase nsun2 |
1.48 |
2.1.1.29 |
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| 29436 |
PF3D7_1305400 |
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AAR2 protein, putative |
1.48 |
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| 29261 |
PF3D7_0209700 |
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RING zinc finger protein, putative |
1.47 |
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| 29468 |
PF3D7_1426000 |
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60S ribosomal protein L21 |
1.40 |
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| 29311 |
PF3D7_0528800 |
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nuclear GTP-binding protein, putative |
1.39 |
3.6.5.2 |
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| 29438 |
PF3D7_1308300 |
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40S ribosomal protein S27 |
1.36 |
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| 29858 |
PF3D7_0621300 |
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mRNA-binding protein puf3 |
1.36 |
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| 29364 |
PF3D7_0907700 |
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proteasome activator 28 |
1.33 |
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| 29483 |
PF3D7_1458000 |
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cysteine proteinase falcipain 1 |
1.26 |
3.4.22.- |
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| 29318 |
PF3D7_0608700 |
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T-complex protein 1 subunit zeta |
0.78 |
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| 29310 |
PF3D7_0528100 |
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AP-1/2 complex subunit beta, putative |
0.77 |
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29301 |
PF3D7_0509800 |
|
|
phosphatidylinositol 4-kinase beta |
0.77 |
2.7.1.67 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29486 |
PF3D7_1466300 |
|
|
26S proteasome regulatory subunit RPN2, putative |
0.76 |
3.4.25.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29309 |
PF3D7_0527500 |
|
|
Hsc70-interacting protein |
0.76 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29381 |
PF3D7_1030100 |
|
|
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative |
0.75 |
3.6.4.13 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29472 |
PF3D7_1434300 |
|
|
Hsp70/Hsp90 organizing protein |
0.75 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29399 |
PF3D7_1124100 |
|
|
beach domain-containing protein, putative |
0.75 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29340 |
PF3D7_0717400 |
|
|
queuine tRNA-ribosyltransferase, putative |
0.75 |
2.4.2.29 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29329 |
PF3D7_0707900 |
|
|
ribosomal protein S8e, putative |
0.75 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29452 |
PF3D7_1350100 |
|
|
lysine--tRNA ligase |
0.74 |
6.1.1.6 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29275 |
PF3D7_0319600 |
|
|
elongation factor 1-delta, putative |
0.74 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29317 |
PF3D7_0607000 |
|
|
translation initiation factor IF-2, putative |
0.73 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 33925 |
PF3D7_1244800 |
|
|
translation machinery-associated protein 46, putative |
0.73 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29437 |
PF3D7_1306400 |
|
|
26S protease regulatory subunit 10B, putative; 26S proteasome AAA-ATPase subunit RPT4, putative |
0.72 |
3.6.4.8 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29451 |
PF3D7_1347500 |
|
|
DNA/RNA-binding protein Alba 4 |
0.72 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29434 |
PF3D7_1302700 |
|
|
ATP-dependent RNA helicase dhr1, putative |
0.72 |
3.6.4.13 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29430 |
PF3D7_1250800 |
|
|
DNA repair protein rhp16, putative |
0.72 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29425 |
PF3D7_1244100 |
|
|
N-alpha-acetyltransferase 15, NatA auxiliary subunit, putative |
0.72 |
2.3.1.88 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29305 |
PF3D7_0518300 |
|
|
proteasome subunit beta type-1, putative |
0.71 |
3.4.25.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29331 |
PF3D7_0709600 |
|
|
ribonucleases P/MRP protein subunit POP1, putative |
0.71 |
3.1.26.5 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29339 |
PF3D7_0716000 |
|
|
RNA-binding protein, putative |
0.71 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29299 |
PF3D7_0508700 |
|
|
pre-mRNA-processing ATP-dependent RNA helicase PRP5, putative |
0.71 |
3.6.4.13 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29366 |
PF3D7_0913200 |
|
|
elongation factor 1-beta |
0.71 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29454 |
PF3D7_1354300 |
|
|
large subunit rRNA methyltransferase, putative |
0.70 |
2.1.1.- |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29457 |
PF3D7_1360100 |
|
|
RNA-binding protein, putative |
0.70 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29291 |
PF3D7_0420000 |
|
|
zinc finger protein, putative |
0.70 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29357 |
PF3D7_0826100 |
|
|
HECT-like E3 ubiquitin ligase, putative |
0.69 |
6.3.2.19 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29257 |
PF3D7_0201800 |
|
|
knob associated heat shock protein 40 |
0.69 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29445 |
PF3D7_1322100 |
|
|
set domain-containing protein 2 |
0.69 |
2.1.1.43 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29367 |
PF3D7_0915100 |
|
|
SUMO-conjugating enzyme UBC9 |
0.69 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29444 |
PF3D7_1321700 |
|
|
splicing factor 1 |
0.69 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29302 |
PF3D7_0511000 |
|
|
translationally-controlled tumor protein homolog |
0.69 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29287 |
PF3D7_0415300 |
|
|
cdc2-related protein kinase 3 |
0.68 |
2.7.11.22 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29298 |
PF3D7_0506700 |
|
|
GTPase-activating protein, putative |
0.68 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29281 |
PF3D7_0405400 |
|
|
pre-mRNA-processing-splicing factor 8, putative |
0.68 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29412 |
PF3D7_1214600 |
|
|
adrenodoxin-type ferredoxin, putative |
0.68 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29447 |
PF3D7_1344200 |
|
|
PfHsp70-y |
0.68 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29421 |
PF3D7_1235300 |
|
|
CCR4-NOT transcription complex subunit 4, putative |
0.67 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29400 |
PF3D7_1124800 |
|
|
ribosome biogenesis regulatory protein, putative |
0.67 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29465 |
PF3D7_1412700 |
|
|
AAA family ATPase, putative |
0.67 |
3.6.1.3 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29378 |
PF3D7_1025000 |
|
|
eps15-like protein |
0.67 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29307 |
PF3D7_0522300 |
|
|
S-adenosylmethionine-dependent methyltransferase, putative |
0.67 |
2.1.1.12 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29475 |
PF3D7_1439100 |
|
|
DEAD/DEAH box helicase, putative |
0.67 |
3.6.4.13 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29373 |
PF3D7_1011800 |
|
|
PRE-binding protein |
0.67 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29387 |
PF3D7_1102700 |
|
|
early transcribed membrane protein 11.1 |
0.67 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29467 |
PF3D7_1423200 |
|
|
peptidyl-prolyl cis-trans isomerase |
0.67 |
5.2.1.8 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29345 |
PF3D7_0801700 |
|
|
sentrin-specific protease 2, putative |
0.66 |
5.3.1.8 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29398 |
PF3D7_1123100 |
|
|
calcium-dependent protein kinase 7 |
0.66 |
2.7.11.17 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29265 |
PF3D7_0218700 |
|
|
pre-mRNA-processing protein 45, putative |
0.66 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29355 |
PF3D7_0823200 |
|
|
RNA-binding protein, putative |
0.65 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29429 |
PF3D7_1247400 |
|
|
peptidyl-prolyl cis-trans isomerase fkbp |
0.65 |
5.2.1.8 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29466 |
PF3D7_1414500 |
|
|
atypical protein kinase, ABC-1 family, putative |
0.64 |
1.14.13.- |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29300 |
PF3D7_0509000 |
|
|
alpha-soluble nsf attachment protein, putative |
0.64 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29262 |
PF3D7_0211800 |
|
|
asparagine--tRNA ligase |
0.64 |
6.1.1.22 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29480 |
PF3D7_1451100 |
|
|
elongation factor 2 |
0.64 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29482 |
PF3D7_1457000 |
|
|
signal peptide peptidase |
0.64 |
3.4.21.89 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29256 |
PF3D7_0201600 |
|
|
PHISTb domain-containing RESA-like protein 1 |
0.64 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29406 |
PF3D7_1149500 |
|
|
ring-infected erythrocyte surface antigen 2, pseudogene |
0.64 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29395 |
PF3D7_1115200 |
|
|
histone-lysine n-methyltransferase set7 |
0.63 |
2.1.1.43 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29327 |
PF3D7_0704600 |
|
|
HECT-type E3 ubiquitin ligase UT |
0.63 |
6.3.2.19 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29260 |
PF3D7_0202500 |
|
|
early transcribed membrane protein 2 |
0.63 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29391 |
PF3D7_1108600 |
|
|
endoplasmic reticulum-resident calcium binding protein |
0.63 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29374 |
PF3D7_1012000 |
|
|
ring zinc finger protein, putative |
0.62 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29481 |
PF3D7_1451800 |
|
|
sortilin |
0.62 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29288 |
PF3D7_0416000 |
|
|
RNA-binding protein, putative |
0.62 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29476 |
PF3D7_1444800 |
|
|
fructose-bisphosphate aldolase |
0.62 |
4.1.2.13 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29485 |
PF3D7_1462800 |
|
|
glyceraldehyde-3-phosphate dehydrogenase |
0.62 |
1.2.1.12 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29410 |
PF3D7_1208600 |
|
|
mitochondrial import inner membrane translocase subunit TIM10, putative |
0.62 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29403 |
PF3D7_1128100 |
|
|
prefoldin subunit 5, putative |
0.61 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29419 |
PF3D7_1231600 |
|
|
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP2, putative |
0.61 |
3.6.4.13 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29439 |
PF3D7_1309100 |
|
|
60S ribosomal protein L24, putative |
0.61 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29330 |
PF3D7_0708500 |
|
|
heat shock protein 86 family protein |
0.60 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29286 |
PF3D7_0413900 |
|
|
ubiquitin carboxyl-terminal hydrolase 13, putative |
0.60 |
3.4.19.12 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29440 |
PF3D7_1309400 |
|
|
HORMA domain protein, putative |
0.59 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29356 |
PF3D7_0823800 |
|
|
DnaJ protein, putative |
0.59 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29464 |
PF3D7_1401600 |
|
|
Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
0.59 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29370 |
PF3D7_0935900 |
|
|
ring-exported protein 1 |
0.59 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29379 |
PF3D7_1027300 |
|
|
peroxiredoxin merozoite capping protein 1 |
0.59 |
1.11.1.15 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29435 |
PF3D7_1303100 |
|
|
methyltransferase, putative |
0.59 |
2.1.1.37 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29414 |
PF3D7_1223400 |
|
|
phospholipid-transporting ATPase, putative |
0.59 |
3.6.3.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29448 |
PF3D7_1344800 |
|
|
aspartate carbamoyltransferase |
0.59 |
2.1.3.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29461 |
PF3D7_1373500 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.58 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29446 |
PF3D7_1324200 |
|
|
micro-fibrillar-associated protein, putative |
0.58 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29489 |
PF3D7_1424500 |
|
|
small nucleolar RNA snoR27 |
0.56 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29349 |
PF3D7_0808600 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.56 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29428 |
PF3D7_1246600 |
|
|
pre-mRNA-splicing factor CWC26, putative |
0.55 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29463 |
PF3D7_1401400 |
|
|
early transcribed membrane protein 14.1 |
0.55 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29266 |
PF3D7_0220500 |
|
|
Plasmodium exported protein (hyp2), unknown function |
0.55 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29371 |
PF3D7_0936800 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
0.54 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29433 |
PF3D7_1301400 |
|
|
Plasmodium exported protein (hyp12), unknown function |
0.54 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29363 |
PF3D7_0905300 |
|
|
dynein heavy chain, putative |
0.54 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29276 |
PF3D7_0323000 |
|
|
translation machinery-associated protein 7, putative |
0.54 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29289 |
PF3D7_0416100 |
|
|
glutamyl-tRNA(Gln) amidotransferase subunit A |
0.53 |
6.3.5.7 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29388 |
PF3D7_1102800 |
|
|
early transcribed membrane protein 11.2 |
0.53 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29282 |
PF3D7_0411900 |
|
|
DNA polymerase alpha |
0.53 |
2.7.7.7 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29283 |
PF3D7_0412400 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.53 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29295 |
PF3D7_0501300 |
|
|
skeleton-binding protein 1 |
0.53 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29422 |
PF3D7_1240400 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.52 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29420 |
PF3D7_1232200 |
|
|
dihydrolipoyl dehydrogenase, mitochondrial |
0.52 |
1.8.1.4 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38931 |
PF3D7_0519500 |
|
|
ccr4 domain-containing protein 1, putative |
0.52 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29360 |
PF3D7_0833500 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.51 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29350 |
PF3D7_0808700 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.51 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29359 |
PF3D7_0831700 |
|
|
PfHsp70-x |
0.51 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29380 |
PF3D7_1028000 |
|
|
methyltransferase, putative |
0.50 |
2.1.1.61 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29303 |
PF3D7_0512000 |
|
|
prefoldin subunit 6 |
0.49 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29342 |
PF3D7_0733000 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.49 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29326 |
PF3D7_0700100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.48 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29304 |
PF3D7_0513600 |
|
|
deoxyribodipyrimidine photo-lyase, putative |
0.48 |
4.1.99.3 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29296 |
PF3D7_0501400 |
|
|
interspersed repeat antigen |
0.48 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29292 |
PF3D7_0421300 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.48 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29390 |
PF3D7_1105100 |
|
|
histone H2B |
0.48 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29344 |
PF3D7_0800300 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.48 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29397 |
PF3D7_1122900 |
|
|
dynein heavy chain, putative |
0.47 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29279 |
PF3D7_0400200 |
|
|
erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene |
0.47 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29337 |
PF3D7_0712900 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.47 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29383 |
PF3D7_1041300 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.47 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29488 |
PF3D7_1341100 |
|
|
U6 spliceosomal RNA |
0.47 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29352 |
PF3D7_0810800 |
|
|
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase |
0.46 |
2.5.1.15 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29268 |
PF3D7_0300100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.46 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29267 |
PF3D7_0223500 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.45 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29332 |
PF3D7_0711700 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.45 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29285 |
PF3D7_0412900 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.44 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29312 |
PF3D7_0532300 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
0.44 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29334 |
PF3D7_0712300 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.43 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29423 |
PF3D7_1240600 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.43 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29324 |
PF3D7_0631600 |
|
|
Plasmodium exported protein (hyp5), unknown function exported protein family 4 |
0.43 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29325 |
PF3D7_0632800 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.42 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 33977 |
PF3D7_1316600 |
|
|
CTP:phosphocholine cytidylyltransferase |
0.42 |
2.7.7.15 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 39001 |
mal_rna_17 |
|
|
large subunit ribosomal RNA fragment E |
0.42 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29346 |
PF3D7_0802000 |
|
|
glutamate dehydrogenase, putative |
0.42 |
1.4.1.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29277 |
PF3D7_0324900 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.41 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29294 |
PF3D7_0500100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.41 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29384 |
PF3D7_1100100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.41 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29382 |
PF3D7_1035800 |
|
|
probable protein, unknown function |
0.41 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29255 |
PF3D7_0200100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.41 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29313 |
PF3D7_0532400 |
|
|
lysine-rich membrane-associated PHISTb protein |
0.40 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29462 |
PF3D7_1400100 |
|
|
erythrocyte membrane protein 1 (PfEMP1), truncated, pseudogene |
0.40 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29297 |
PF3D7_0503100 |
|
|
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative |
0.40 |
2.7.1.148 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29372 |
PF3D7_1000100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.40 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29336 |
PF3D7_0712800 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.39 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29424 |
PF3D7_1240900 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.38 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29272 |
PF3D7_0316600 |
|
|
formate-nitrite transporter, FNT |
0.38 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29284 |
PF3D7_0412700 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.37 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29271 |
PF3D7_0311700 |
|
|
plasmepsin VI |
0.36 |
3.4.23.- |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29361 |
PF3D7_0900100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.36 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29252 |
PF3D7_0113000 |
|
|
glutamic acid-rich protein |
0.36 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29365 |
PF3D7_0907900 |
|
|
peptide deformylase |
0.36 |
3.5.1.88 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29432 |
PF3D7_1255200 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.36 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29258 |
PF3D7_0201900 |
|
|
erythrocyte membrane protein 3 |
0.35 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29333 |
PF3D7_0712000 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.34 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29407 |
PF3D7_1200100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.33 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29278 |
PF3D7_0400100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.33 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29343 |
PF3D7_0800100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.33 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29469 |
PF3D7_1427200 |
|
|
selenoprotein |
0.33 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38234 |
mal_rna_11 |
|
|
mal_rna_11:rRNA |
0.32 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38235 |
PF3D7_1421150 |
|
|
C/D small nucleolar RNA |
0.32 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29416 |
PF3D7_1224000 |
|
|
GTP cyclohydrolase I |
0.31 |
3.5.4.16 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29314 |
PF3D7_0600600 |
|
|
erythrocyte membrane protein 1 (PfEMP1), exon 2 |
0.31 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29254 |
PF3D7_0115700 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.31 |
|
 |
|
|
|
|
|
|
|
|
|
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|
|
| 29335 |
PF3D7_0712600 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.30 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29351 |
PF3D7_0809100 |
|
|
erythrocyte membrane protein 1, PfEMP1 |
0.29 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
| 29408 |
PF3D7_1200200 |
|
|
PIR protein rifin |
0.28 |
|
|
|
|
|
|
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|
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|
|
|
|
|
|
|
|
|
|
| 29491 |
PF3D7_1244300 |
|
|
ACEA small nucleolar RNA U3 |
0.26 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29253 |
PF3D7_0115200 |
|
|
rifin PIR protein |
0.24 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
| 29263 |
PF3D7_0216000 |
|
|
DEAD/DEAH box helicase, putative |
0.24 |
3.6.4.13 |
 |
|
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| 29415 |
PF3D7_1223900 |
|
|
50S ribosomal protein L24, putative |
0.21 |
|
 |
|
|
|
|
|
|
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|
|
|
|
|
|
|
|
|
|
|
| 29259 |
PF3D7_0202000 |
|
|
knob-associated histidine-rich protein |
0.21 |
|
 |
|
|
|
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|
|
|
|
|
|
|
|
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|
|
| 29251 |
PF3D7_0101000 |
|
|
rifin PIR protein |
0.21 |
|
|
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|
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|
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| 29490 |
PF3D7_1213100 |
|
|
U1 spliceosomal RNA |
0.20 |
|
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|
+ 100 conserved proteins, unknown function and 13 conserved Plasmodium membrane protein, unknown function |
|
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