Zinc-finger proteins
Ngwa CJ, Farrukh A, Pradel G. Zinc finger proteins of Plasmodium falciparum. Cell Microbiol. 2021 Aug 21:e13387. PMID: 34418264.
PfID Annotation PFam Description Zinc Finger Motif Description Zinc Finger Group Peak Transcript Expression P. falciparum piggyBac Mutagenesis Screens # of Zinc finger Domains Transcript
PF3D7_0818500 zinc finger protein, putative AN1-like Zinc finger;A20-like zinc finger Zf_AN1 Zinc finger AN1-type profile AN1-type Schizonts Essential 2
PF3D7_0409800 zinc finger protein, putative C2H2 type zinc-finger (2 copies) Zf-C2H2_2 C2H2 type zinc-finger C2H2 -type GC stage V Essential 2
PF3D7_0619900 splicing factor 3A subunit 2, putative Zinc-finger of C2H2 type;Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) Zf-met Zinc-finger of C2H2 type C2H2 -type GC stage V Non-essential 1
PF3D7_1005600 DnaJ protein, putative DnaJ domain;Zinc-finger of C2H2 type Zf-met Zinc-finger of C2H2 type C2H2 -type Ookinetes Essential 2
PF3D7_1009400 zinc finger protein, putative N/A C2H2 C2H2 -type Late trophs Non-essential 1
PF3D7_0805300 conserved Plasmodium protein, unknown function Zinc _finger_C2H2_2 zing finer C2h2 type domain ZINC_FINGER_C2H2_2 Zinc finger C2H2 type domain profile C2H2 -type GC Stage V Non-essential 1
PF3D7_1464400 zinc finger protein, putative Zinc-finger double-stranded RNA-binding Zf-C2H2_jaz Zinc-finger double-stranded RNA-binding C2H2 -type GC stage II Essential 1
PF3D7_1468900 zinc finger protein, putative N/A ZINC_FINGER_C2H2_2 Zinc finger C2H2 type domain profile C2H2 -type Early trophs Non-essential 1
PF3D7_1243100 zinc finger protein, putative Zinc-finger double-stranded RNA-binding Zf-C2H2_jaz Zinc-finger double-stranded RNA-binding C2H2 -type Ookinetes Essential 1
PF3D7_1209300
telomere repeat-binding zinc finger protein, putative Zinc finger, C2H2 type Zf-C2H2 Zinc finger, C2H2 type C2H2 -type Schizonts Non-essential 1
PF3D7_0602000 zinc finger protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type GC stage V Non-essential 1
PF3D7_0818100 zinc finger protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type schizonts Non-essential 1
PF3D7_1119300 splicing factor U2AF small subunit, putative RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);Zinc finger C-x8-C-x5-C-x3-H type (and similar) Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Late trophs Essential 1
PF3D7_1419900 YTH domain-containing protein 1, putative, YTH1 YT521-B-like domain Zf C3H1 Zf_C3H1 Zinc finger C3H1-type profile CCCH-type GC stage V Essential 1
PF3D7_0515000 pre-mRNA-splicing factor CWC2, putative RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);Torus domain Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Schizonts Non-essential 1
PF3D7_0623100 nuclear polyadenylated rna-binding protein nab2 RNA-binding, Nab2-type zinc finger (Zf-CCCH) Zf-CCCH_2 RNA-binding, Nab2-type zinc finger CCCH-type Rings Essential 1
PF3D7_1358500 zinc finger protein, putative ZPR1 zinc-finger domain Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Early trophs Essential 1
PF3D7_1425600 zinc finger protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type GC stage V Non-essential 2
PF3D7_0519600 zinc finger protein, putative C3HC zinc finger-like Zf-C3HC C3HC zinc finger-like CCCH-type Early trophs Essential 1
PF3D7_0525000 zinc finger protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Early trophs Non-essential 1
PF3D7_1443800 pre-mrna-splicing factor cwc24 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Zf_C3H1 Zinc finger C3H1-type profile CCCH-type GC stage V Essential 1
PF3D7_1464200 zinc finger ccch domain-containing protein, putative Zinc finger C-x8-C-x5-C-x3-H type (and similar) Zf_C3H1 Zinc finger C3H1-type profile CCCH-type GC stage V Essential 1
PF3D7_1315400 zinc finger (CCCH type) protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Late trophs Essential 1
PF3D7_1220000 zinc finger protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Ookinetes Essential 1
PF3D7_1244800 translation machinery-associated protein 46, putative DRG Family Regulatory Proteins, Tma46, Zf_c3H1 Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Early trophs Non-essential 2
PF3D7_1248200 RNA-binding protein, putative RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);Zinc finger C-x8-C-x5-C-x3-H type (and similar) Zf_C3H1 Zinc finger C3H1-type profile CCCH-type GC stage V Essential 1
PF3D7_0315600 zinc finger protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Ookinetes Non-essential 1
PF3D7_0522900 zinc finger protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Ookinetes Non-essential 2
PF3D7_0906600 zinc finger protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Rings Non-essential 1
PF3D7_0927200 zinc finger protein, putative Zinc finger C-x8-C-x5-C-x3-H type (and similar) Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Ookinetes Essential 2
PF3D7_1008600 zinc finger (ccch type) protein, putative Zinc finger C-x8-C-x5-C-x3-H type (and similar) Zf_C3H1 Zinc finger C3H1-type profile CCCH-type GC stage V Essential 2
PF3D7_1019300 zinc finger protein, putative Zinc finger C-x8-C-x5-C-x3-H type (and similar) Zf_C3H1 Zinc finger C3H1-type profile CCCH-type GC stage V Non-essential 2
PF3D7_1134600 zinc finger protein, putative Zinc finger C-x8-C-x5-C-x3-H type (and similar) Zf_C3H1 Zinc finger C3H1-type profile CCCH-type GC stage V Non-essential 2
PF3D7_1207200 conserved Plasmodium protein, unknown function Zf_C3H1 Zinc finger C3Hh1 type profile Zf_C3H1 Zinc finger C3Hh1 type profile CCCH-type GC stage V Non-essential 1
PF3D7_1210200 zinc finger protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Ookinetes Non-essential 1
PF3D7_1468400
zinc finger protein, putative Zf_C3H1 Zinc finger C3H1-type profile Zf_C3H1 Zinc finger C3H1-type profile CCCH-type Late trophs Non-essential 1
PF3D7_1414100 zinc finger protein, putative Zinc knuckle Zf_CCHC Zinc finger CCHC-type profile CCHC-type Rings Essential 2
PF3D7_0420000 zinc finger protein, putative CW-type Zinc Finger Zf-CW CW-type Zinc Finger CW-type Early trophs Non-essential 2
PF3D7_0729700 conserved Plasmodium protein, unknown function HIT/MYND zinc finger-like HIT/MYND zinc finger-like HIT-type GC stage V Essential 1
PF3D7_0912100 zinc finger protein, putative HIT zinc finger Zf-HIT HIT zinc finger HIT-type Early trophs Essential 1
PF3D7_0916900 zinc finger protein, putative N/A Zf_HIT Zinc finger HIT-type profile HIT-type GC stage V Non-essential 1
PF3D7_1415900 zinc finger protein, putative HIT zinc finger Zf-HIT HIT zinc finger HIT-type GC stage II Essential 1
PF3D7_1355300
histone-lysine N-methyltransferase, putative SET domain;MYND finger HIT/MYND zinc finger-like HIT-type GC stage V Essential 1
PF3D7_0804300 zinc finger protein, putative N/A HIT/MYND zinc finger-like HIT-type Rings Non-essential 1
PF3D7_0924700 splicing factor 3A subunit 3, putative Domain of unknown function (DUF3449);Splicing factor SF3a60 binding domain;Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Zf_MATRIN Zinc finger matrin-type profile matrin-type Ookinetes Essential 1
PF3D7_1402400 zinc finger protein, putative N/A Zf_MATRIN Zinc finger matrin-type profile matrin-type Ookinetes Essential 1
PF3D7_0602200 MYND-type zinc finger protein, putative MYND finger MYND-type zinc finger protein, putative MYND-type Early trophs Essential 1
PF3D7_0607100 MYND finger protein, putative MYND finger MYND-type zinc finger protein, putative MYND-type GC stage V Non-essential 1
PF3D7_1015300
methionine aminopeptidase 1b, putative Metallopeptidase family M24;Zf-MYND-like zinc finger, mRNA-binding Zf-C6H2 Zf-MYND-like zinc finger, mRNA-binding MYND-type Early trophs Non-essential 1
PF3D7_1432800 hp12 protein homolog, putative Zf-MYND-like zinc finger, mRNA-binding Zf-C6H2 Zf-MYND-like zinc finger, mRNA-binding MYND-type Ookinetes Essential 1
PF3D7_0609100 zinc transporter zip1, putative ZIP Zinc transporter Zip ZIP Zinc transporter others GC Stage V Essential 1
PF3D7_0612600 cytoplasmic tRNA 2-thiolation protein 1, putative PP-loop family;Zinc-ribbon zn-ribbon_14 Zinc-ribbon others Schizonts Non-essential 1
PF3D7_0110800
transcription initiation factor TFIIB, putative Transcription factor TFIIB repeat;TFIIB zinc-binding Zf_TFIIB Zinc finger TFIIB-type profile others Early trophs Essential 1
PF3D7_0110400 DNA-directed RNA polymerase II subunit RPB9, putative RNA polymerases M/15 Kd subunit Zf_TFIIS_2 Zinc finger TFIIS-type profile others GC stage V Essential 2
PF3D7_0103400 zinc-carboxypeptidase, putative Zn-dependent exopeptidases Zn-dependent exopeptidases others GC stage V Non-essential 1
PF3D7_0206600 DNA-directed RNA polymerase III subunit RPC10, putative Transcription factor S-II (TFIIS) Zf_TFIIS_2 Zinc finger TFIIS-type profile others Rings Essential 1
PF3D7_0213900 rtr1 domain-containing protein, putative Rtr1/RPAP2 family Zf_RTR1 RTR1-type zinc finger others Early trophs Essential 1
PF3D7_1022300 ZIP domain-containing protein, putative, ZIPCO ZIP Zinc transporter Zip ZIP Zinc transporter others GC stage II Non-essential 1
PF3D7_1030000 transcription elongation factor SPT4, putative Spt4/RpoE2 zinc finger Spt4 Spt4/RpoE2 zinc finger others GC stage II Essential 1
PF3D7_1204600 cytidine deaminase, putative Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_1 Cytidine and deoxycytidylate deaminase zinc-binding region others GC stage V Essential 1
PF3D7_1206700 eukaryotic translation initiation factor 5, putative Domain found in IF2B/IF5 Zinc-binding domain of translation initiation factor 2 beta others Early trophs Essential 1
PF3D7_1208600 mitochondrial import inner membrane translocase subunit TIM10, putative Tim10/DDP family zinc finger Zf-Tim10_DDP Tim10/DDP family zinc finger others GC stage II Essential 1
PF3D7_1437900
HSP40, subfamily A DnaJ domain;DnaJ central domain;DnaJ C terminal domain Zf_CR Zinc finger CR-type profile others Early trophs Essential 1
PF3D7_0722300 ubiquitin carboxyl-terminal hydrolase, putative Zn-finger in ubiquitin-hydrolases and other protein Zf_UBP Zinc finger UBP-type profile others Rings Non-essential 1
PF3D7_0822600
protein transport protein SEC23 Gelsolin repeat;Sec23/Sec24 zinc finger;Sec23/Sec24 trunk domain;Sec23/Sec24 helical domain;Sec23/Sec24 beta-sandwich domain Zn-finger domain of Sec23/24 others Late trophs Essential 1
PF3D7_0418700 RNA-binding protein NOB1, putative Nin one binding (NOB1) Zn-ribbon like;PIN domain of ribonuclease NOB1_Zn_bind Nin one binding (NOB1) Zn-ribbon like others Ookinetes Essential 1
PF3D7_0706400 60S ribosomal protein L37 Ribosomal protein L37e Zn-binding ribosomal proteins others Early trophs Essential 1
PF3D7_0708100 DNA-directed RNA polymerases I, II, and III subunit RPABC5, putative RNA polymerases N / 8 kDa subunit RNA POLYMERASE DNA-DIRECTED SUBUNIT TRANSFERASE NUCLEOTIDYLTRANSFERASE METAL-BINDING ZINC TRANSCRIPTION N others GC stage V Essential 1
PF3D7_0914600 transcription elongation factor 1, putative Transcription elongation factor Elf1 like Zinc beta-ribbon others GC stage II Essential 1
PF3D7_0918600
ATP-dependent DNA helicase Q1; bloom protein homolog DEAD/DEAH box helicase;Helicase conserved C-terminal domain;RecQ zinc-binding RecQ_Zn_bind RecQ zinc-binding others GC stage V Non-essential 1
PF3D7_0925600 zinc binding protein (Yippee), putative Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Yippee-Mis18 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly others GC stage II Non-essential 1
PF3D7_0927800 COX5B cytochrome c oxidase subunit 5B, putative Cytochrome c oxidase subunit Vb COX5B_2 Cytochrome c oxidase subunit Vb, zinc binding domain profile others Schizonts Essential 1
PF3D7_0930400 zinc finger protein, putative Myb-like DNA-binding domain;CHY zinc finger Zf_CHY Zinc finger CHY-type profile others Ookinetes Non-essential 2
PF3D7_0405100 protein transport protein Sec24B, putative Sec23/Sec24 trunk domain;Sec23/Sec24 helical domain; Sec23/Sec24 beta-sandwich domain  Zn-finger domain of Sec23/24 others Late trophs Essential 1
PF3D7_0407300 transcription factor, putative Transcription factor S-II (TFIIS) Zf_TFIIS_2 Zinc finger TFIIS-type profile others Ookinetes Essential 1
PF3D7_0409400
chaperone protein dnaj; heat shock protein 40 DnaJ domain;DnaJ central domain;DnaJ C terminal domain Zf_CR Zinc finger CR-type profile others Early trophs Non-essential 1
PF3D7_1429900
ADP-dependent DNA helicase RecQ DEAD/DEAH box helicase;Helicase conserved C-terminal domain;RQC domain;RecQ zinc-binding RecQ_Zn_bind RecQ zinc-bindin others GC stage V Non-essential 1
PF3D7_1421500 mitochondrial import inner membrane translocase subunit TIM8, putative Tim10/DDP family zinc finger Zf-Tim10_DDP Tim10/DDP family zinc finger others Early trophs Non-essential 1
PF3D7_1420300 DNL-type zinc finger protein; hsp70-escort protein 1 DNL zinc finger Zf-DNL DNL zinc finger others GC stage V Essential 1
PF3D7_0502800 DnaJ protein, putative DnaJ domain;CSL zinc finger Zf-CSL CSL zinc finger others Rings Non-essential 1
PF3D7_0502900 TIM10/ddp family zinc finger protein, putative Tim10/DDP family zinc finger Zf-Tim10_DDP Tim10/DDP family zinc finge others GC stage II Essential 1
PF3D7_0504100 AN1-type zinc finger protein, putative AN1-like Zinc finger RecQ_Zn_bind RecQ zinc-bindin others GC stage V Essential 1
PF3D7_0507700 nuclear protein localization protein 4, putative NPL4 family, putative zinc binding region;NPL4 family;Nuclear pore localisation protein NPL4 Zf-NPL4 NPL4 family, putative zinc binding region others Ookinetes Essential 1
PF3D7_0623600 splicing factor-like protein, putative KH domain;Splicing factor 1 helix-hairpin domain Retrovirus zinc finger-like domains others Late trophs Non-essential 1
PF3D7_1361100
protein transport protein Sec24A Gelsolin repeat;Sec23/Sec24 zinc finger;Sec23/Sec24 trunk domain;Sec23/Sec24 helical domain;Sec23/Sec24 beta-sandwich domain  Zn-finger domain of Sec23/24 others Schizonts Essential 1
PF3D7_1368600 mitochondrial import inner membrane translocase subunit TIM9, putative Tim10/DDP family zinc finger Zf-Tim10_DDP Tim10/DDP family zinc finger others GC stage V Essential 1
PF3D7_1005500 regulator of nonsense transcripts 1, putative RNA helicase (UPF2 interacting domain);AAA domain;AAA domain UPF1_Zn_bind RNA helicase (UPF2 interacting domain) others Late trophs Non-essential 1
PF3D7_1010600 eukaryotic translation initiation factor 2 subunit beta, putative Domain found in IF2B/IF5  Zinc-binding domain of translation initiation factor 2 beta others Rings Essential 1
PF3D7_0804900 GTPase-activating protein, putative Putative GTPase activating protein for Arf ArfGap/RecO-like zinc finger others Ookinetes Non-essential 1
PF3D7_0517900 zinc finger protein, putative B-box zinc finger B-box zinc-binding domain others Late trophs Essential 2
PF3D7_1440400 zinc finger protein, putative Zf_BBOX Zinc finger B-box type profile Zf_BBOX Zinc finger B-box type profile others Schizonts Essential 2
PF3D7_1460800 snRNA-activating protein complex subunit 3, putative snRNA-activating protein of 50kDa MW C terminal Zf-SNAP50_C snRNA-activating protein of 50kDa MW C termina others Ookinetes Essential 1
PF3D7_1467500 DNA/RNA-binding protein KIN17, putative Domain of Kin17 curved DNA-binding protein beta-beta-alpha zinc fingers others Late trophs Essential 1
PF3D7_1337400 zinc finger protein, putative Putative zinc finger motif, C2HC5-type Zf-C2HC5 Putative zinc finger motif, C2HC5-type others GC stage V Non-essential 1
PF3D7_1349400 cytidine and deoxycytidylate deaminase, putative Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_1 Cytidine and deoxycytidylate deaminase zinc-binding region others Rings Non-essential 1
PF3D7_1307900 tripartite motif protein, putative Zf_BBOX Zinc finger B-box type profile Zf_BBOX Zinc finger B-box type profile others Schizonts Essential 2
PF3D7_1308300 40S ribosomal protein S27 Ribosomal protein S27 Zn-binding ribosomal proteins others GC stage II Essential 1
PF3D7_1321200 conserved protein, unknown function 4F5 protein family;Zinc-binding Zf-met2 Zinc-binding others GC stage V Essential 1
PF3D7_0714500 transcription elongation factor s-II, putative Transcription factor S-II (TFIIS);Transcription factor S-II (TFIIS), central domain;TFIIS helical bundle-like domain Zinc beta-ribbon others GC stage V Essential 1
PF3D7_0812800 conserved protein, unknown function 4F5 protein family;Zinc-binding Zf-met2 Zinc-binding others Ookinetes Essential 1
PF3D7_0812700 U1 small nuclear ribonucleoprotein c, putative U1 zinc finger Zf-U1 U1 zinc finger others Schizonts Non-essential 1
PF3D7_1217800 diphthamide biosynthesis protein 3, putative CSL zinc finger Zf-CSL CSL zinc finger others Rings Essential 1
PF3D7_1242900 mitochondrial import inner membrane translocase subunit TIM13, putative Tim10/DDP family zinc finger Zf-Tim10_DDP Tim10/DDP family zinc finger others GC stage V Essential 1
PF3D7_0308100 zinc finger protein, putative Zf_BBOX Zinc finger B-box type profile Zf_BBOX Zinc finger B-box type profile others Ookinetes Non-essential 1
PF3D7_0809900 jmjc domain-containing protein 1, putative JmjC domain, hydroxylase;C5HC2 zinc finger Zf-C5HC2 C5HC2 zinc finger others GC stage V Non-essential 1
PF3D7_0930500 diacylglycerol kinase, putative Diacylglycerol kinase accessory domain;Diacylglycerol kinase catalytic domain Zf_DAG_PE_2 Zinc finger phorbol-ester/DAG-type profile others Schizonts Non-essential 1
PF3D7_1358600 zinc finger protein, putative Zf-ZPR1 ZPR1 zinc-finger domain Zf-ZPR1 ZPR1 zinc-finger domain others Ookinetes Non-essential 2
PF3D7_1141800
EELM2 domain-containing protein, putative PHD-finger;Extended EGL-27 and MTA1 homology domain Zf_PHD_2 Zinc finger PHD-type profile PHD-type Schizonts Non-essential 1
PF3D7_0624600
iswi chromatin-remodeling complex atpase SNF2 family N-terminal domain;Helicase conserved C-terminal domain;PHD-finger FYVE/PHD zinc finge PHD-type Rings Non-essential 5
PF3D7_1460100
FYVE and coiled-coil domain-containing protein FYVE zinc finger FYVE/PHD zinc finge PHD-type GC stage V Essential 1
PF3D7_1310300 zinc finger protein, putative FYVE zinc finger FYVE/PHD zinc finger PHD-type Ookinetes Essential 1
PF3D7_1221000
histone-lysine N-methyltransferase, H3 lysine-4 specific PHD-finger FYVE/PHD zinc finger PHD-type Late trophs Non-essential 1
PF3D7_0310200 phd finger protein, putative PHD-finger;PHD-zinc-finger like domain PHD-finger;PHD-zinc-finger like domain PHD-type Early trophs Non-essential 3
PF3D7_0629700
SET domain protein, putative FYVE/PHD zinc finger FYVE/PHD zinc finger PHD-type Ookinetes Non-essential 1
PF3D7_1008100 phd finger protein phd1 PHD-finger;PHD-like zinc-binding domain PHD-finger;PHD-like zinc-binding domain PHD-type Early trophs Non-essential 4
PF3D7_1211600
lysine-specific histone demethylase 1, putative FYVE zinc finger FYVE/PHD zinc finge PHD-type Ookinetes Non-essential 1
PF3D7_1322100
set domain-containing protein 2 FYVE/PHD zinc finger PHD zinc finger PHD-type Rings Non-essential 1
PF3D7_1433400 phd finger protein phd2, putative PHD-like zinc-binding domain;PHD-zinc-finger like domain PHD-like zinc-binding domain;PHD-zinc-finger like domain PHD-type Late trophs Essential 2
PF3D7_0408300 zinc finger ran-binding domain-containing protein 2, putative Zn-finger in Ran binding protein and others Zf-RanBP Zn-finger in Ran binding protein and other RANBP2-type Early trophs Essential 2
PF3D7_1353400 Ran-binding protein, putative Zf_RANBP2_2 Zinc finger RanBP2 type profile Zf_RANBP2_2 Zinc finger RanBP2 type profile RANBP2-type Early trophs Non-essential 1
PF3D7_1317400 zinc finger protein, putative N/A Zf-RanBP Zn-finger in Ran binding protein and other RANBP2-type GC stage V Essential 1
PF3D7_0603400
trophozoite exported protein 1 Zinc finger, C3HC4 type (RING finger) Zf-C3HC4_3 Zinc finger, C3HC4 type (RING finger RING finger Early trophs Non-essential 1
PF3D7_0607200 RING zinc finger protein, putative Ring finger domain Zf-RING_2 Ring finger domain RING finger GC stage V Non-essential 1
PF3D7_0728600 ring zinc finger protein, putative RING-type zinc-finger Zf-RING_UBOX RING-type zinc-finger RING finger Ookinetes Non-essential 1
PF3D7_0215100 RING zinc finger protein, putative Zinc finger, C3HC4 type (RING finger) Zf-C3HC4_2 Zinc finger, C3HC4 type (RING finger RING finger Ookinetes Essential 1
PF3D7_0303800 IBR domain protein, putative IBR domain, a half RING-finger domain RING/U-box RING finger GC stage V Non-essential 1
PF3D7_0312100
E3 ubiquitin-protein ligase, putative Ring finger domain Zf-RING_2 Ring finger domai RING finger Late trophs Essential 2
PF3D7_0314700
ring finger protein rnf1 Ring finger domain Zf-RING_2 Ring finger domain RING finger GC stage II Non-essential 1
PF3D7_1028200 ring zinc finger protein, putative Ring finger domain Zf-RING_2 Ring finger domain RING finger GC stage V Essential 1
PF3D7_1205500 zinc finger protein, putative zinc finger of C3HC4-type, RING Zf-C3HC4_4 zinc finger of C3HC4-type, RING RING finger Rings Non-essential 1
PF3D7_1208800 zinc finger protein, putative Zinc finger, C3HC4 type (RING finger) Zf-C3HC4_4 zinc finger of C3HC4-type, RING RING finger GC Stage V Non-essential 1
PF3D7_0825500 protein KRI1, putative KRI1-like family C-terminal RING/U-box RING finger Rings Essential 1
PF3D7_0413900 ubiquitin carboxyl-terminal hydrolase 13, putative Ubiquitin carboxyl-terminal hydrolase;Zn-finger in ubiquitin-hydrolases and other protein;Fungal ubiquitin-associated domain RING/U-box RING finger Late trophs Essential 2
PF3D7_0319100 E3 ubiquitin-protein ligase RBX1, putative RING-H2 zinc finger domain Zf_RING_2 Zinc finger RING-type profile RING finger GC stage II Essential 1
PF3D7_0316900
E3 ubiquitin-protein ligase, putative Zinc finger, C3HC4 type (RING finger) Zf-C3HC4_3 Zinc finger, C3HC4 type (RING finger) RING finger Rings Non-essential 1
PF3D7_0909700 FHA domain protein, putative FHA domain;RING-variant domain Zf_RING_CH Zinc finger RING-CH-type profile RING finger GC stage V Non-essential 1
PF3D7_0926900 replication termination factor, putative Rtf2 RING-finger Rtf2 Rtf2 RING-finger RING finger Ookinetes Non-essential 1
PF3D7_1123300 RING zinc finger protein, putative Zinc finger, C3HC4 type (RING finger) Zf-C3HC4_2 Zinc finger, C3HC4 type (RING finger RING finger GC stage V Non-essential 1
PF3D7_1422500
ERAD-associated E3 ubiquitin-protein ligase HRD1 Ring finger domain Zf-RING_2 Ring finger domain RING finger GC stage V Essential 1
PF3D7_1405700 RING zinc finger protein, putative Ring finger domain Zf_RING_2 Zinc finger RING-type profile RING finger GC stage V Essential 1
PF3D7_0502000
vacuolar protein sorting-associated protein 11, putative Vacuolar protein sorting protein 11 C terminal Zf_RING_2 Zinc finger RING-type profile RING finger GC stage V Essential 1
PF3D7_0512300 CDK-activating kinase assembly factor mat1 Zinc finger, C3HC4 type (RING finger);CDK-activating kinase assembly factor MAT1 Zf-C3HC4 Zinc finger, C3HC4 type (RING finger) RING finger GC stage V Essential 1
PF3D7_0624500 anaphase-promoting complex subunit 11, putative Anaphase-promoting complex subunit 11 RING-H2 finger AN1-like Zinc finger RING finger GC Stage II Essential 1
PF3D7_0627300 E3 ubiquitin-protein ligase RNF5, putative Zinc finger, C3HC4 type (RING finger) Zf-C3HC4_3 Zinc finger, C3HC4 type (RING finger) RING finger Late trophs Non-essential 1
PF3D7_1360700 E3 SUMO-protein ligase PIAS, putative MIZ/SP-RING zinc finger RING zinc finger RING finger Late trophs Essential 2
PF3D7_1004300 E3 ubiquitin-protein ligase, putative Ring finger domain Zf_RING_2 Zinc finger RING-type profile RING finger Rings Essential 1
PF3D7_1007300 RING zinc finger protein, putative Ring finger domain Zf-RING_2 Ring finger domain RING finger Ookinetes Essential 1
PF3D7_1012000 ring zinc finger protein, putative Zinc finger, C3HC4 type (RING finger) Zf_RING_2 Zinc finger RING-type profile RING finger Ookinetes Non-essential 1
PF3D7_1014600 transcriptional coactivator ADA2 Myb-like DNA-binding domain;Zinc finger, ZZ type  RING/U-box RING finger Early trophs Essential 2
PF3D7_0615600 zinc finger protein, putative RING/U-box RING/U-box RING finger Rings Non-essential 1
PF3D7_0518000 NOSIP domain-containing protein, putative Zinc-finger of nitric oxide synthase-interacting protein RING/U-box RING finger GC stage V Non-essential 1
PF3D7_0529900 RING zinc finger protein, putative Ring finger domain Zf-RING_2 Ring finger domain RING finger GC stage II Non-essential 1
PF3D7_1450400 E3 ubiquitin-protein ligase znf598, putative RING/U-box RING/U-box RING finger Rings Non-essential 1
PF3D7_1451300 E3 SUMO-protein ligase NSE2, putative Zinc-finger of the MIZ type in Nse subunit RING/U-box RING finger GC stage V Essential 1
PF3D7_1334000 ring zinc finger protein, putative Ring finger domain Zf-RING_2 Ring finger domain RING finger GC stage V Essential 1
PF3D7_1343400 DNA repair protein RAD5, putative SNF2 family N-terminal domain;Helicase conserved C-terminal domain Zf_RING_2 Zinc finger RING-type profile RING finger Late trophs Non-essential 1
PF3D7_1344300 zinc finger protein, putative FHA domain;RING-variant domain Zf_RING_CH Zinc finger RING-CH-type profile RING finger Schizonts Non-essential 1
PF3D7_1345000 conserved Plasmodium protein, unknown function Zf_RING_2Zinc finger RING-type profile Zf_RING_2 Zinc finger RING-type profile RING finger GC stage V Essential 1
PF3D7_1309700 vacuolar protein sorting-associated protein 18, putative Pep3/Vps18/deep orange family RING/U-box RING finger Rings Essential 1
PF3D7_1314900
general transcription factor IIH subunit 2 Zf_RING_2 Zinc finger RING-type profile Zf_RING_2 Zinc finger RING-type profile RING finger Late trophs Essential 1
PF3D7_1317000 U4/U6.U5 tri-snRNP-associated protein 2, putative Ubiquitin carboxyl-terminal hydrolase;Zn-finger in ubiquitin-hydrolases and other protein RING/U-box RING finger Late trophs Essential 1
PF3D7_1235300 CCR4-NOT transcription complex subunit 4, putative RING/Ubox like zinc-binding domain Zf-RING_4 RING/Ubox like zinc-binding domain RING finger Rings Essential 1
PF3D7_1250800 DNA repair protein rhp16, putative SNF2 family N-terminal domain;Helicase conserved C-terminal domain;Ring finger domain Zf-RING_2 Ring finger domain RING finger Early trophs Non-essential 2
PF3D7_0209700 RING zinc finger protein, putative Zinc finger, C3HC4 type (RING finger) Zf-C3HC4_2 Zinc finger, C3HC4 type (RING finger RING finger Early trophs Essential 1
PF3D7_0315800 zinc finger protein, putative, HAKAI RING/U-box RING/U-box RING finger GC satge V Non-essential 2
PF3D7_0415800
phil1-interacting candidate pic3 Zinc finger, C3HC4 type (RING finger) Zf-C3HC4_2 Zinc finger, C3HC4 type (RING finger) RING finger GC stage V Non-essential 1
PF3D7_0521300 zinc finger protein, putative RING/U-box RING/U-box RING finger GC stage V Non-essential 1
PF3D7_1013000 zinc finger protein, putative Zf_RING_2 Zinc finger RING-type profile Zf_RING_2 Zinc finger RING-type profile RING finger Late trophs Non-essential 1
PF3D7_1233600 asparagine and aspartate rich protein 1 Putative zinc finger in N-recognin (UBR box) Zf-ANAPC11 Anaphase-promoting complex subunit 11 RING-H2 finger RING finger Ookinetes Non-essential 1
PF3D7_0315000 zinc finger protein, putative SWIM zinc finger SWIM SWIM zinc finger SWIM-type GC stage II Non-essential 1
The ZFPs were identified and classified using a text query with term “zinc finger proteins” in the PlasmoDB database (https://plasmodb.org).
Gene essentiality analyses were performed using the PiggyBac mutagenesis screen by Zhang et al. (2018) (https://science.sciencemag.org/content/suppl/2018/05/02/360.6388.eaap7847.DC1, Table S5) for P. falciparum and the database PlasmoGEM (https://plasmoge
DNA triplett base specificity prediction analyses for C2H2-ZFPs were performed using the software tool B1H (http://zf.princeton.edu/b1h/protein.html).
Online articles related to Zinc-finger proteins retrieved from PubMed