The fate of the parasitophorous vacuolar membrane
Electron micrographs of a P. falciparum-infected RBC showing a trophozoite and schizont stage parasite. Plasmodium resides within a parasitophorous vacuole at all stages of the intraerythrocytic life
Gene expression affected by lumefantrine
Transient drug tolerance was associated with major changes in gene expression profiles: 184 differentially expressed genes in V1SLM were identified. Among those are 18 known and putative transporters
In vitro resistance to experimental antimalarials
An increased understanding of and exploitation to our own advantage of these mechanisms will provide unique opportunities to reduce the impact of resistance, and make a powerful contribution to improv
Mechanism of resistance to artemisinin
Levels of the PfPI3K enzyme are regulated by PfKelch13, a protein that binds to PfPI3K and mediates the addition of ubiquitin groups (Ub), tagging PfPI3K for degradation. ART and its derivatives are a
Fungal compounds with antimlarial action
Fungi produce a diversity of metabolites that play important biological roles in human well-being. Thus, they are considered a potential source of novel natural agents for exploitation in the pharmace
Antimalarial activity of plant metabolites
This table covers the structures of compounds with antiplasmodial activity isolated from plants and is organized
according to plant family. A total of 170 structures has been reviewed from 186 refere
Researchers selected a fungus, Metarhizium pingshaense, which naturally infects malaria-carrying mosquitoes.
This fungus was then genetically modified so that it would produce a toxin found in the venom of a species of funnel-web spider.
Trials in Burkina Faso found that a fungus, modified so that it produces spider toxin,
quickly killed large numbers of mosquitos that carry malaria.Within 45 days,
mosquito populations were drastically reduced by more than 90%.
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