Protein nitrosylation and denitrosylation
S-nitrosylation (or S-nitrosation) and the formation of S-nitrosothiols (RSNOs) has emerged as an important feature of NO signaling. The RSNOs range in size from low molecular mass (LMM), such as S-ni
Cell apoptosis in malaria
During the development processes, Plasmodium invades a variety of cells in two hosts. The invaded cells tend to undergo apoptosis and are subsequently removed from the system. This process also elimin
Peroxidase active organelles
Staining with 3,3 diaminobenzidine tetrahydrochloride (DAB) is a common method used for the detection of peroxidases. Using this histochemical staining method in conjunction with transmission electro
Food vacuole proteome
The Plasmodium falciparum food vacuole (FV) is a lysosome-like organelle where erythrocyte hemoglobin digestion occurs. It is a favorite target in the development of antimalarials. We have used a tand
Mitochondrial LSU rRNA secondary structure
The mitochondrial genome in the human malaria parasite Plasmodium falciparum is most unusual. Over half the genome is composed of the genes for three classic mitochondrial proteins: cytochrome oxidase
Researchers selected a fungus, Metarhizium pingshaense, which naturally infects malaria-carrying mosquitoes.
This fungus was then genetically modified so that it would produce a toxin found in the venom of a species of funnel-web spider.
Trials in Burkina Faso found that a fungus, modified so that it produces spider toxin,
quickly killed large numbers of mosquitos that carry malaria.Within 45 days,
mosquito populations were drastically reduced by more than 90%.
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