The different RNA export pathways
The major RNA export routes are shown. In each case, the primary RNA transcript is shown, as well as the transport-competent RNA RNA after it has undergone processing, maturation and assembly with exp
Nuclear export of tRNA
Small RNAs follow relatively simple export routes by binding directly to export receptors. Large RNAs assemble into complicated ribonucleoprotein (RNP) particles
Gene gating and mRNA export
The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species are exported throughnuclear pore complexes via mobile export receptors
Transcription related proteins encoding genes
A comprehensive directory of potential transcription-associated proteins. In addition, all complete transcriptome, proteome and interactome raw data were re-analysed, compared and discussed
P. falciparum genes harboring G-quadruplexes
The striking genomic features of P. falciparum, wherein GC richness is uniquely localized in parasite's AT rich genome hint towards existence of regulatory elements in GC rich regions.
Malaria Parasite Metabolic Pathways (MPMP) upgraded with targeted chemical compounds
The Malaria Parasite Metabolic Pathways (MPMP) functional genomics database (MPMP.huji.ac.il)
has been initiated 15 years ago and is being constantly expanded and updated based on literature publications .
It consists of maps and tables that organize the annotated genes of the parasite genome in a functional context.
It already contains expression data and all the information about the sub-cellular location of annotated encoded genes.
At the present time it was thought useful to add the drug-related data to this information resource.
As of October 1st, 2015, more than 3,300 publications (and growing at 2-5 papers/week) were retrieved.
These were read and selected according to the following criteria to be admitted to the final drug list.
Each entry into the drug database includes drug name (or suggested target),
ID of the gene that encodes for the target or the name of a functional process,
and the PubMed ID of the publication from which the data were obtained.
Each drug is linked to a drug database.
Once entered into MPMP the drugs are easily visible through another new feature that was added recently:
when a map is uploaded on the screen, the full list of its constituents appears in a
tabular form at the bottom. Those that serve as a drug target are indicated by an
Rx icon and pressing on the ID leads to a page that contains all the information mentioned above.
The search engine can also be used to search for a drug,
by drug name and by target and metabolic pathway name.
Data will be collected as they become available on the web and the site will be readily updated.
By compiling all anti-malarial drug related info coming from cell-,
chemistry- and target-based approaches, MPMP provides a resource that assists
knowledge-guided discovery and development of new drug candidates.
Compiled and maintained by
Hagai Ginsburg This site is graciously hosted by The Hebrew University of Jerusalem