Latest Updates

Last update: 19/03/2024

  • 19/03/2024

    Epigenetics and Epitranscriptomics Schematic of epigenetics and epitranscriptomics. Epigenetics includes chemical modifications of DNA and histone proteins. Epitranscriptomics refers to all chemical modifications on RNA. Figure created with BioRender.com. Abbreviations: ?, pseudouridine; n
  • 19/03/2024

    DNA methylation is mediated by DNA methyltransferases Bi-directional synthesis In many prokaryotes two replication forks develop from at the initiation site, each initiation fork traveling in opposite directions as shown here. Thus, what strand is lagging or leading depends on which replication fork you are
  • 13/03/2024

    Merozoite tomograph Cryo-ET with Volta Phase Plate reveals the organization of subcellular organelles in Plasmodium falciparum merozoites. (A) Tomographic slice of a representative merozoite (left) and its 3D annotation showing the apical rings (orange), rhoptries (red), mem
  • 06/03/2024

    Parasitophorous vacuole proteins Validation of parasitophorous vacuole localizationVacuolar residency is most commonly validated by genetic incorporation of protein tags, as opposed to the laborious and time-consuming generation of specific antibodies for immunofluorescence. Proper valid
  • 05/03/2024

    The parasitophorous vacuole (PV) membrane The parasitophorous vacuole (PV) membrane (PVM) (blue) undergoes distinct morphological phases during parasite egress. On completion of schizogony, the merozoites align around the central food vacuole (dark brown) and the parasitophorous vacuole rounds up
  • 05/03/2024

    PLCd1 PH domain; pleckstrin homology (PH) domains of PLCd1 from the plasma membranes Infection of human erythrocytes by the apicomplexan malaria parasite Plasmodium falciparum results in endovacuolar uptake of 4 host proteins that reside in erythrocyte detergent-resistant membranes (DRMs). Whether this vacuolar transport reflects selecti
  • 03/03/2024

    Model of lipid and protein uptake into the erythrocyte DIV and the malarial vacuole (A) The erythrocyte membrane contains a variety of phospholipids (PS, PI/PIP2, PE, PG, etc) and raft (stomatin, flotillins) and nonraft (actin, spectrin) proteins, most of which are taken up into DIV membranes. However, PE- and PG-type phospholipids are s
  • 01/03/2024

    Vacuolar secretion pathways Vacuolar secretion pathways in Plasmodium. Effectors and virulence factors follow the general SRP/Sec61-dependent (Signal Recognition Particle/Sec61 translocon) parasitic secretion pathway starting in the endoplasmic reticulum (ER) and progressing through
  • 28/02/2024

    Cytoadherence events in the vascular system Cytoadherence events and main actors in the vascular system that takes place during P. falciparum infection and development in humans. ICAM-1: Adhesion Molecule-1, VCAM: Vascular cellular adhesion molecule, TSP: Thrombospondin, CD62P: P-selectin, CD62E: E
  • 12/02/2024

    Isoprenoid biosynthesis new Isoprenoid biosynthesis by mevalonate dependent (MVA) and non-mevalonate pathway (MEP) in a typical cell. Isoprenoids are derived from the basic 5-carbon isoprenoid building blocks IPP and its isomer, DMAPP. In the MVA pathway IPP and DMAPP are synthesize