Immunofluorescence images showing the endoplasmic reticulum (ER) morphology in AlF4 and vinblastine treated parasites. (A) PfBiP localization in control parasites for AlF4- treatment, (B) ER morphology in AlF4- treated parasites (14 parasites were counted, none showed dispersal of ER struc-

ture), (C) PfBiP localization in solvent (PBS) control parasites for vinblastine treatment, (D) ER morphology in vinblastine-treated parasites (26 parasites were counted, none showed dispersal), (E) ER morphology in parasites reverted after vinblastine treatment (27 parasites counted). Scale Bar: 10 mm. Unlike mammalian cells, no disintegration of the ER was observed in parasites subjected to vinblastine and AlF4-.Both control parasites and drug-treated parasites showed perinuclear ER morphology consistent with the normal development of the ER.

Chaudhari R, Dey V, Narayan A, Sharma S, Patankar S. Membrane and luminal proteins reach the apicoplast by different trafficking pathways in the malaria parasite Plasmodium falciparum. PeerJ. 2017 Apr 27;5:e3128.