You can find more information about
using the following links:
PlasmoDB - the Plasmodium genome resource
The TDR Targets Database
PDB protein strucure
3FNS
3FNT
3FNU
3QVC
3QVI
6KUC
6KUB
6KUD
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
(4R)-N-tert-Butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide
High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor(2003)
4-(5-(4-methoxyphenyl)- 1’phenyl-3’-(p-tolyl)-3,4- 1’H,2H-[3,4’-bipyrazol]-2- yl)benezenesulfonamide
Molecular docking and dynamics studies on novel benzene sulfonamide substituted pyrazole-pyrazoline analogues as potent inhibitors of Plasmodium falciparum Histo aspartic protease(2020)
Alln
Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Atazanavir
Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Diphenylurea
Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Doxorubicin
Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring(2009)
E-64
Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Fragment-based docking and consensus scoring, halofantrine, doxorubicin, lumefantrine
Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring(2009)
G16
Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites(2009)
Halofantrine
Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring(2009)
Indinavir
Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Kni-10006
Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum(2009)
Kni-10395
Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum(2011)
Leupeptin
Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Lopinavir
Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Lumefantrine
Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring(2009)
Nelfinavir
Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Pepstatin a
Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum(2009)
Antimalarial activity of thiosemicarbazones and purine derived nitriles(2009)
Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Molecular modeling and prediction of binding mode and relative binding affinity of Art-Qui-OH with P. falciparum Histo-Aspartic Protease (HAP)(2012)
Purine
Antimalarial activity of thiosemicarbazones and purine derived nitriles(2009)
Ritonavir
Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Ro 40-4388
Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Saquinavir
Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Sucralfate
A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast(2013)
Suggested target
Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy(2004)
X-ray structures and 3d models , suggested target
Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations(2008)
ZINC02619047
Unveiling a New Era in Malaria Therapeutics: A Tailored Molecular Approach Towards the Design of Plasmepsin IX Inhibitors(2019)