You can find more information about
using the following links:
PlasmoDB - the Plasmodium genome resource
The TDR Targets Database
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
Antimycin
Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors(2015)
Interplay between the hinge region of iron sulphur protein and the Qo site in the bc1 complex - Analysis of Plasmodium-like mutations in the yeast enzyme(2015)
Atovaquone
Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors(2015)
Interplay between the hinge region of iron sulphur protein and the Qo site in the bc1 complex - Analysis of Plasmodium-like mutations in the yeast enzyme(2015)
Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites(2017)
Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors(2018)
Azoxystrobin
Interplay between the hinge region of iron sulphur protein and the Qo site in the bc1 complex - Analysis of Plasmodium-like mutations in the yeast enzyme(2015)
CK-2-68
Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors(2018)
Metabolic network analysis, suggested target
Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis(2010)
Ml-238
Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors(2015)
N-(3-isobutyramidophenyl)-3-(2-oxobenzo[d]thiazol-3(2H)-yl)propanamide
High-throughput virtual screening approach involving pharmacophore mapping, ADME filtering, molecular docking and MM-GBSA to identify new dual target inhibitors of Pf DHODH and Pf Cytbc1 complex to combat drug resistant malaria(2020)
N-(4-Chloro-2,5-dimethoxyphenyl)-2-[(9-oxo-9,10-dihydro-2-acridinyl)oxy]acetamide
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials(2018)
N-cyclopropyl-5-[(4-methylphenyl)methylsulfanylmethyl]furan-2-carboxamide
Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum(2016)
Quinolone
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria(2012)
RYL-552
Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors(2018)
TCMDC-136129
Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum(2018)