You can find more information about cysteine proteinase falcipain 3 using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_1115400

PF11_0162

cysteine proteinase falcipain 3

PlasmoDB

TDR

(S)-N-((S,E)-6-((S)-2-((1H-indol-3-yl)methyl)-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol1-yl)-6-oxo-1-phenylhex-4-en-3-yl)-2-((S)-2-((S)-2-(dimethylamino)-3- methylbutanamido)-4-methylpentanamido)-4-methylpentanamideꞏtrifluoroacetate	Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials
(s)-n-[1-(cyanomethylamino)-4-methyl-1-oxopentan-2-yl] biphenyl-4-carboxamide	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
[4-[(5-cyclohexa-1,3-dien-1-yl-3-hydroxy-2-oxo-pentyl)carbamoyl]tetrahydrothiopyran-4-yl]carbamic acid	Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of a-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum
1,2,4-trioxolane	Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity
1-[4-chloro-2-(2-hydroxybutoxy)phenyl]butane-1,2-dione	Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid
10202732	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
1me3	Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library
2 n-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[1-(2-methoxyethyl)piperidin-4-yl] benzamide , (s)-n-[1-(cyanomethylamino)-4-methyl- 1-oxopentan-2-yl] biphenyl-4-carboxamide, n-(s)- 4-methyl-1-oxo-1-{[r]-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4- ylaminopentan-2-yl}benzofuran-2-carboxamide, n-(s)- 4-methyl-1-oxo-1-{[s]-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4- ylaminopentan-2-yl}benzofuran-2-carboxamide, benzyl (2s,2 s)-1,1 -[2,2 -carbonylbis(hydrazine-2,1-diyl)]bis(4-methyl-1-oxopentane-2,1-diyl)dicarbamate, cbz-leu-nhnh-c(o)-o-bz , cbz-leu-nh-nh-c(o)-o-ph] and n-(s)-4-methyl-1-oxo-1-{[s,e]-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-ylaminopentan-2-yl} morpholine-4-carboxamide	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
2-[2,3-dichloro-4-(2-oxobutanoyl)phenoxy]-N-phenacyl-acetamide	Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid
2oz2	Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library
2-pyridone	Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors
3i06	Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library
4-[[5-(5-morpholinosulfonyl-2-thienyl)-2-thienyl]sulfonyl]morpholine	Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory
5-(1,2,3,4,6,6a-hexahydrothieno[3,4-d]imidazol-3a-yl)-N-[6-[[2-[2,3-dichloro-4-(2-oxobutanoyl)phenoxy]acetyl]amino]hexyl]pentanamide	Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid
5-phenylthiazole	a-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
6-[1-[[2,3-dichloro-4-(2-oxobutanoyl)phenoxy]methyl]vinylamino]hexanoic acid	Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid
6-benzyloxy-1-(4-benzyloxyphenyl)-7-methoxy-isoquinoline	Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow
7-aminocoumarin	De novo design of 7-aminocoumarin derivatives as novel falcipain-3 inhibitors
8-azapurine	Functionalized hydroxyethylamine based peptide nanostructures as potential inhibitors of falcipain-3, an essential proteases of Plasmodium falciparum
Alln	Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum
Artemisinin	Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
Aziridine-2,3-dicarboxylate	Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate
Aziridine-2,3-dicarboxylic acid	Screening of protease inhibitors as antiplasmodial agents. Part I: Aziridines and epoxides
Aziridine-2-carboxylic acid	New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors
Aziridine-2-carboxylic acid	Screening of protease inhibitors as antiplasmodial agents. Part I: Aziridines and epoxides
Benzothiazole	a-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
Benzoxazine	a-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
Benzyl (2s,2's)-1,1 -[2,2 -carbonylbis(hydrazine-2,1-diyl)]bis(4-methyl-1-oxopentane-2,1-diyl)dicarbamate	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
benzyl 2-[(3R)-3-(2-cyclohexa-1,3-dien-1-ylethyl)-4-oxo-5-(p-tolyl)pentanoyl]pyrrolidine-1-carboxylate;methylsulfanylethane	Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of a-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum
benzyl 2-[(3R)-3-(2-cyclohexa-1,3-dien-1-ylethyl)-5-hydroxy-4-oxo-pentanoyl]pyrrolidine-1-carboxylate	Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of a-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum
Boc-(s)-phg-(r/s)-vgln(trt)-oet	Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids
Cathepsin inhibitor library	Mining a cathepsin inhibitor library for new antiparasitic drug leads
Cbz-leu-nhnh-c(o)-o-bz	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
Cbz-leu-nh-nh-c(o)-o-ph	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
Chagasin	The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family Study of protein complexes via homology modeling, applied to cysteine proteases and their protein inhibitors
Chembridge hydrazone and imine compounds	Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database
Crystal structure in complex with leupeptin	Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity
CYS-cIHL	Cyclic peptide engineered from phytocystatin inhibitory hairpin loop as an effective modulator of falcipains and potent antimalarial
Cystatin	The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family
Cystatin a	Study of protein complexes via homology modeling, applied to cysteine proteases and their protein inhibitors
Cystatin c	Study of protein complexes via homology modeling, applied to cysteine proteases and their protein inhibitors
Cysteine protease inhibitor library	Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library
Dibenzyl aziridine	Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells
Dihydroartemisinin	Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
D-vlk-cmk	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
E-64	Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity
E64d	Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
E-64d	Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids	Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity
Ethacrynic acid	Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid
ethyl 2-[2-chloro-4-(2-oxobutanoyl)phenoxy]acetate	Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid
Falstatin	Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion Study of protein complexes via homology modeling, applied to cysteine proteases and their protein inhibitors
Homophenylalanylketones	Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of a-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum
Hydroxamic acid	Discovery of new potential antimalarial compounds using virtual screening of ZINC database
Isoxazoles	a-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
K11017	Vinyl sulfones as antiparasitic agents and a structural basis for drug design
Kininogen	Study of protein complexes via homology modeling, applied to cysteine proteases and their protein inhibitors
Leupeptin	The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family Vinyl sulfones as antiparasitic agents and a structural basis for drug design Computation-based virtual screening for designing novel antimalarial drugs by targeting falcipain-III: a structure-based drug designing approach
Lhvs	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
Mg-132	Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132
Modeling and docking studies, suggested target	Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies
Mu-leu-hph-vsph	Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum
N-(2H-1,3-benzodioxol-5-yl)-N'-[2-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)ethyl]ethanediamid	Microsecond-long simulation reveals the molecular mechanism for the dual inhibition of falcipain-2 and falcipain-3 by antimalarial lead compounds
N-(3-([1,1'-biphenyl]-4-carboxamido)propyl)-1H-indole-2-carboxamide	Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity
N'-(3-cyanophenyl)-N'-cyclohexyl-4-(4-methyl-1-piperidyl)benzohydrazide	Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow
N'-(3-cyanophenyl)-N'-cyclopentyl-3-[4-(1-piperidylmethyl)phenyl]benzohydrazide	Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow
N'-(5-bromo-2-cyano-pyrimidin-4-yl)-N'-[(2R)-2-methylcyclopentyl]-4-[(4-methylpiperazin-1-yl)methyl]benzohydrazide	Binding affinity models for Falcipain inhibition based on the Linear Interaction Energy method
N-(s)- 4-methyl-1-oxo-1-{[r]-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4- ylaminopentan-2-yl}benzofuran-2-carboxamide	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
N-(s)-4-methyl-1-oxo-1-{[s,e]-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-ylaminopentan-2-yl} morpholine-4-carboxamide	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[1-(2-methoxyethyl)piperidin-4-yl] benzamide	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
N-[2-[[3-hydroxy-1-[[7-hydroxy-2-[(Z)-prop-1-enyl]-1H-indol-4-yl]methyl]propyl]amino]-2-oxo-ethyl]naphthalene-1-carboxamide	Computation-based virtual screening for designing novel antimalarial drugs by targeting falcipain-III: a structure-based drug designing approach
N-[3-(dimethylsulfamoyl)phenyl]-5-isoxazol-3-yl-tetrahydrothiophene-2-sulfonamide	Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory
N2,N7-bis(2-furylmethyl)-9H-fluorene-2,7-disulfonamide	Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory
N-acetyl-Leu-Leu-norLeu	Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
N-benzyl-N'-[(Z)-[1-[2-(3-methylanilino)-2-oxo-ethyl]-2-oxo-indolin-3-ylidene]amino]oxamide	Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory
N-tert-butyl-2-(2-fluoro-4-(2-methylenebutanoyl)phenoxy)acetamide	Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid
Oxadiazole	a-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
Pepstatin	Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3
Pmsf	Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3
Pyrazoleamide	Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials
SAHA	a-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB a-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
Statine	Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs
stefin-A	Structure-Based Optimization of Protease-Inhibitor Interactions to Enhance Specificity of Human Stefin-A against Falcipain-2 from the Plasmodium falciparum 3D7 Strain
structural analysis, suggested target	Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substrates
Structure-based virtual screening suggested target	Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis
Substrate specificity, suggested target	Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3
sugarcane cystatin	Inhibition of Plasmodium falciparum cysteine proteases by the sugarcane cystatin CaneCPI-4
Suggested target	Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole Novel anti-plasmodial hits identified by virtual screening of the ZINC database
Symplostatin	The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains
Synthetic peptidyl aldehyde and alpha-ketoamide cysteine protease inhibitors	Antimalarial activities of novel synthetic cysteine protease inhibitors
Tarocystatin	Study of protein complexes via homology modeling, applied to cysteine proteases and their protein inhibitors
Tcmdc-135965	Thousands of chemical starting points for antimalarial lead identification
tert-butyl N-[(2-cyano-5-nitro-pyrimidin-4-yl)-isobutyl-amino]carbamate	Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series
tert-butyl N-[(5-bromo-2-cyano-pyrimidin-4-yl)-cyclohexyl-amino]carbamate	Binding affinity models for Falcipain inhibition based on the Linear Interaction Energy method
tert-butyl N-[(5-chloro-2-cyano-pyrimidin-4-yl)-isobutyl-amino]carbamate	Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series
tert-butyl N-[(6-chloro-5-cyano-pyrazin-2-yl)-isobutyl-amino]carbamate	Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series
tert-butyl N-[(6-cyano-4-methoxy-pyrazin-2-yl)-isobutyl-amino]carbamate	Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series
tert-butyl N-[(6-cyanopyrazin-2-yl)-isobutyl-amino]carbamate	Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series
Thiophene	Mining a cathepsin inhibitor library for new antiparasitic drug leads
Triazole	a-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
Vinyl sulfone	Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory Vinyl sulfones as antiparasitic agents and a structural basis for drug design Mining a cathepsin inhibitor library for new antiparasitic drug leads
yoelipain 2	Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design
ZINC69668302	Discovery of new potential antimalarial compounds using virtual screening of ZINC database
ZINC76061857	Discovery of new potential antimalarial compounds using virtual screening of ZINC database
ZINC78241300	Discovery of new potential antimalarial compounds using virtual screening of ZINC database
ZINC90631044	Discovery of new potential antimalarial compounds using virtual screening of ZINC database
ZINC97034145	Discovery of new potential antimalarial compounds using virtual screening of ZINC database
Z-lly-fmk	Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
Zphe-arg-fmk	Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3

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