You can find more information about
GTP cyclohydrolase I
using the following links:
PFID
PFID Old
Formal Annotation
PlasmoDB
TDR Targets
Subcellular Localization
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
PF3D7_1224000
PFL1155w
GTP cyclohydrolase I
PlasmoDB
TDR
6- (phenylhydrazino)uracil, s 6-(p-n-heptylanilino)uracil
Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
8-oxo-GTP
Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
Gene amplification
Origin of robustness in generating drug-resistant malaria parasites
increased copy number
Expansion of GTP cyclohydrolase I copy number in malaria parasites resistant to a pyrimidine biosynthesis inhibitor
Protein expression, suggested target
Co-expression of the Plasmodium falciparum molecular chaperone, PfHsp70, improves the heterologous production of the antimalarial drug target GTP cyclohydrolase I, PfGCHI
Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System
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