You can find more information about
ATP-dependent DNA helicase UvrD
using the following links:
PFID
PFID Old
Formal Annotation
PlasmoDB
TDR Targets
Subcellular Localization
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
PF3D7_0514100
PFE0705c
ATP-dependent DNA helicase UvrD
PlasmoDB
TDR
Picture 1
Daunorubicin
Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth
Difference from host orthologue, suggested target
UvrD helicase of Plasmodium falciparum
Ethidium bromide
Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth
Interaction with dna mismatch repair protein mlh (pf11_0184), suggested target
Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction
Netropsin
Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth
Nogalamycin
Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth
Suggested target
In silico analysis of Plasmodium species specific UvrD helicase
Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System