You can find more information about
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
using the following links:
PFID
PFID Old
Formal Annotation
PlasmoDB
TDR Targets
Subcellular Localization
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
PF3D7_0104400
PFA0225w
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
PlasmoDB
TDR
(e)-4-mercapto-3-methylbut-2-en-1-yl diphosphate
Inhibition of IspH, a [4Fe-4S]2+ enzyme involved in the biosynthesis of isoprenoids via the methylerythritol phosphate pathway
2-dimethylamino-ethyl-diphosphate
An in silico structural insights into Plasmodium LytB protein and its inhibition
3-methyl-3,4-epoxybutyl diphosphate
An in silico structural insights into Plasmodium LytB protein and its inhibition
5-((hydroxymethyl)-o-pyrophosphoryl)uracil
An in silico structural insights into Plasmodium LytB protein and its inhibition
5-diphosphomevalonic acid
An in silico structural insights into Plasmodium LytB protein and its inhibition
Competitive inhibition, suggested target
Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum
Hammerhead ribozyme
Inhibition of Plasmodium falciparum ispH (lytB) gene expression by hammerhead ribozyme
Hmbpp
Inhibition of the 4Fe-4S Proteins IspG and IspH: an EPR, ENDOR and HYSCORE Investigation
In silico, suggested target
In silico prediction of antimalarial drug target candidates
Pyridoxal Diphosphate
Exploration and validation of diphosphate-based Plasmodium LytB inhibitors using computational approaches
Suggested target
Structure of the (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase from Plasmodium falciparum
Utilizing a dynamical description of IspH to aid in the development of novel antimicrobial drugs
Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System
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