You can find more information about a subunits 1-7 using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_0108000

PFA0400c

proteasome subunit beta type-3, putative

PlasmoDB

TDR

((R)-2-([1,1'-biphenyl]-4-yl)-1-((S)-2-((R)-1-acetylpyrrolidine-2-carboxamido)propanamido)ethyl)boronic acid

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

PF3D7_0317000

PFC0745c

proteasome subunit alpha type-3, putative

PlasmoDB

TDR

PF3D7_0518300

PFE0915c

proteasome subunit beta type-1, putative

PlasmoDB

TDR

(S)-2,2-diheptyl-3-(5-(6-methoxyquinolin-8-yl)pentyl)-5-methylimidazolidin-4-one	Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
Bortezomib	Analysis of bortezomib inhibitor docked within the catalytic subunits of the Plasmodium falciparum 20S proteasome

PF3D7_0608500

PFF0420c

proteasome subunit alpha type-2, putative

PlasmoDB

TDR

PF3D7_0727400

PF07_0112

proteasome subunit alpha type-5, putative

PlasmoDB

TDR

(5S,8S,11S)-N-cyclopentyl-11-(1,1-dioxidoisothiazolidin-2-yl)-8-(2-morpholinoethyl)-7,10-dioxo-2-oxa-6,9-diaza-1,3(1,3)-dibenzenacyclododecaphane-5-carboxamide	Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors-Part II
(S)-2-((R)-2-hexanamido-3-methylbutanamido)-N-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)hexanamide	Development of Potent and Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors

PF3D7_0803800

MAL8P1.142

proteasome subunit beta type-4

PlasmoDB

TDR

Chloroquine

Chloroquine mediates specific proteome oxidative damage across the erythrocytic cycle of resistant Plasmodium falciparum

PF3D7_0807500

MAL8P1.128

proteasome subunit alpha type-6, putative

PlasmoDB

TDR

PF3D7_0931800

PFI1545c

proteasome subunit beta type-6, putative

PlasmoDB

TDR

(S)-N1-(2-([1,1'-biphenyl]-4-carboxamido)ethyl)-N4-(tert-butyl)-2-(3-phenylpropanamido)succinamide

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

PF3D7_1011400

PF10_0111

proteasome subunit beta type-5

PlasmoDB

TDR

((R)-1-((S)-2-(2-(4-hydroxyphenyl)acetamido)-3-phenylpropanamido)-3-methylbutyl)boronic acid	Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
(2S)-3-methyl-2-[[(2S)-2-[[(2S)-2-[methyl(pyrazin-2-yl)amino]-4-phenyl-butanoyl]amino]-4-phenyl-butanoyl]amino]-N-(m-tolylmethyl)butanamide	Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome
(S)-N4-(tert-butyl)-N1-(2-(2',4-difluoro-[1,1'-biphenyl]-3-carboxamido)ethyl)-2-((4-methylphenyl)sulfonamido)succinamide	Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
(S)-N4-(tert-butyl)-N1-(2-(3-ethynylbenzamido)ethyl)-2-((4-methylphenyl)sulfonamido)succinamide	Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors
Benzo[b]thiophene	Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome
Bortezomib	Analysis of bortezomib inhibitor docked within the catalytic subunits of the Plasmodium falciparum 20S proteasome
Epoxomicin	Plasmodia express two threonine-peptidase complexes during asexual development The proteasome inhibitor epoxomicin has potent Plasmodium falciparum gametocytocidal activity
Epoxyketone	Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes
N-[(2S)-3-Methyl-1-{[(2S)-1-({(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}amino)-4-(methylsulfonyl)-1-oxo-2-butanyl]amino}-1-oxo-2-butanyl]hexanamide	Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
N-[3-methyl-1-[[1-[[4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-pentyl]amino]-1-oxo-pentyl]amino]-1-oxo-butyl]hexanamide	Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity

PF3D7_1327900

PF13_0156a

conserved Plasmodium protein, unknown function

PlasmoDB

TDR

PF3D7_1353800

PF13_0282

proteasome subunit alpha type-4, putative

PlasmoDB

TDR

PF3D7_1353900

MAL13P1.270

proteasome subunit alpha type-7, putative

PlasmoDB

TDR

PF3D7_1470900

PF14_0676

proteasome subunit beta type-2, putative

PlasmoDB

TDR

(S)-2-((S)-2-(1H-indol-3-yl)-2-(2-morpholinoacetamido)acetamido)-4-methyl-N-((S,E)-5-methyl-1-(methylsulfonyl)hex-1-en-3-yl)pentanamide	Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents
(S)-2-((S)-2-(1H-indol-3-yl)-2-(2-morpholinoacetamido)acetamido)-N-((S,E)-1-(1H-indol-3-yl)-4-(methylsulfonyl)but-3-en-2-yl)-4-methylpentanamide	Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents
Bortezomib	Analysis of bortezomib inhibitor docked within the catalytic subunits of the Plasmodium falciparum 20S proteasome
dihydroartemisinin	A Proteasome Mutation Sensitizes P. falciparum Cam3.II K13 C580Y Parasites to DHA and OZ439
N-[(3S)-1-[1-[(E,1S)-1-ethyl-3-methylsulfonyl-allyl]-5-methyl-2-oxo-3-piperidyl]-5-methyl-2-oxo-3-piperidyl]-2-morpholino-acetamide;indole	Structure- and function-based design of Plasmodium-selective proteasome inhibitors
N-[(3S)-5-(1H-indol-3-yl)-1-[1-[(1S)-3-methyl-1-[(E)-2-methylsulfonylvinyl]butyl]-2-oxo-3-piperidyl]-2-oxo-3-piperidyl]-2-morpholino-acetamide	Structure- and function-based design of Plasmodium-selective proteasome inhibitors
N-[(3S)-5-(1H-indol-3-yl)-1-[1-[(E,1S)-1-(1H-indol-3-ylmethyl)-3-methylsulfonyl-allyl]-5-methyl-2-oxo-3-piperidyl]-2-oxo-3-piperidyl]-2-morpholino-acetamide	Structure- and function-based design of Plasmodium-selective proteasome inhibitors
N-[(3S)-5-(1H-indol-3-yl)-1-[5-methyl-1-[(1R)-3-methyl-1-[(E)-2-methylsulfonylvinyl]butyl]-2-oxo-3-piperidyl]-2-oxo-3-piperidyl]-2-morpholino-acetamide	Structure- and function-based design of Plasmodium-selective proteasome inhibitors
N-[(3S)-5-methyl-1-[1-[(1S)-3-methyl-1-[(E)-2-methylsulfonylvinyl]butyl]-2-oxo-3-piperidyl]-2-oxo-3-piperidyl]-2-morpholino-acetamide	Structure- and function-based design of Plasmodium-selective proteasome inhibitors

PF3D7_1474800

PF14_0716

proteasome subunit alpha type-1, putative

PlasmoDB

TDR

Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System