You can find more information about
glyoxalase I
using the following links:
PlasmoDB - the Plasmodium genome resource
The TDR Targets Database
Subcellular Localization
Picture 1
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
Curcumin
Distinct subcellular localization in the cytosol and apicoplast, unexpected dimerization and inhibition of Plasmodium falciparum glyoxalases(2010)
Tight-binding inhibitors efficiently inactivate both reaction centers of monomeric Plasmodium falciparum glyoxalase 1(2012)
Hydroxycarbamoyl)glutathione
Tight-binding inhibitors efficiently inactivate both reaction centers of monomeric Plasmodium falciparum glyoxalase 1(2012)
Methyl-gerfelin
Distinct subcellular localization in the cytosol and apicoplast, unexpected dimerization and inhibition of Plasmodium falciparum glyoxalases(2010)
Tight-binding inhibitors efficiently inactivate both reaction centers of monomeric Plasmodium falciparum glyoxalase 1(2012)
Phaefuran B
Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry(2018)
Pyroglutamic acid
Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry(2018)
S-(n-hydroxy-n-arylcarbamoyl)
Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts(2005)
Suggested target
Allosteric coupling of two different functional active sites in monomeric Plasmodium falciparum glyoxalase I(2007)