You can find more information about PF3D7_0417200-Dihydrofolate reductase using the following links:

PlasmoDB - the Plasmodium genome resource
Plasmodium falciparum GeneDB
The TDR Targets Database

Subcellular Localization

Affecting Drugs
Drug Name PubMed Articles (year of publication)
N,N,N,N′,N′,N′-Hexamethyl-1,16-hexadecanediaminium Dibromide
(1R,2R,3R,3aS,3a1R,6aS,7aS,11S,11aS,11bS)-2,11-dihydroxy-3,8,11a-trimethyl-5,10-dioxo-1,2,3,3a,4,5,6,6a,7,7a,10,11,11a,11b-tetradecahydro-1,3a1-(epoxymethano)benzo[de]anthracen-4-yl nitroformate
(2E)-3-(4-{[1-(3-chloro-4- fluorophenyl)-1H-1,2,3-triazol-4-yl]methoxy}-3-methoxyphenyl-1-(2-hydroxy-4,6- dimethoxyphenyl)prop-2-en-1-one
(6R)-6-(4-(cyclohex-3-en-1-yloxy)cyclohexyl)-1-phenyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
(E)-N-(4-(N-(1-(3-((3-(3-methylcyclohexyl)benzylidene)amino)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)sulfamoyl)phenyl)acetamide
[(E)-[4-[[3-chloro-5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methyleneamino]thiourea
[4-[[4-[4-[2-[(7-chloro-4-quinolyl)amino]ethyl]piperazin-1-yl]-6-(4-nitroanilino)-1,3,5-triazin-2-yl]amino]anilino]urea
1-(3-(2,4-Dichlorophenoxy)propyl)-6-phenyl-1,6-dihydro- 1,3,5-triazine-2,4-diamine hydrochloride
1-(3-(3,4-Dichlorophenoxy)propyl)-6-phenyl-1,6-dihydro- 1,3,5-triazine-2,4-diamine hydrochloride
1-(4-chloro-3-methyl-phenyl)-2-phenyl-2H-1,3,5-triazine-4,6-diamine
1,2,3-triazole tethered b-lactam and 7-chloroquinoline bifunctional hybrids
1,3,5-triazine
1,3,5-triazine
1-[[1-[(3-chlorophenyl)methyl]-2-oxo-pyridine-3-carbonyl]amino]-3-methyl-thiourea
1-[3′-N-(N′-phenylurenyl)phenyl]- 3(3,4,5-trimethoxyphenyl)-2-propen-1-one
1843u89
1-aryl-4,6-diamino-1,2-dihydro-1,3,5-triazine
1h-imidazole-2,4-diamine
2-(4-(4-(2-((7-chloroquinolin-4-yl)amino)ethyl)piperazin-1-yl)-6-((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)hydrazine-1-carboxamide
2,4 diamino-n10-methyl-pteroic acid
2,4,6-phenyl-pyrimidine
2,4,6-thiomethyl-pyrimidine
2,4,6-trisubstituted pyrimidine
2,4-diamino-5,6,7,8-tetrahydroquinazoline
2,4-diamino-5-chloro-6-[n-(2,5-imethoxybenzyl)amino]quinazoline
2,4-diamino-6-chloro-[1,3,5]triazine
2,4-diamino-6-hydroxymethyl-pteridine
2,4-diaminopteridine
2,4-diaminopteroic acid
2,4-diaminopyrimidine
2,4-diaminoquinazolines
2-[2-(4-{[(3-Methyl-1-oxo-1,2-dihydrobenzo[f]quinazolin-9-yl)methyl]amino}phenyl)-2-oxoethyl]pentanedioic acid
2-[3-(4-fluorophenyl)-1-phenyl-4H-pyrazol-4-yl]-4-methyl-6-oxo-N-(2-pyridyl)-2,5-dihydro-1H-pyridine-3-carboxamide
2-aminopyrimidine
2-methyl-1-(m-tolyl)-2H-1,3,5-triazine-4,6-diamine
3-[(4-chlorophenyl)sulfonylmethyl]-N'-hydroxy-benzamidine
4-((2-Bromonaphthalen-6-yloxy)methyl)-1-(4-nitrobenzyl)-1H-1,2,3-triazole
4-((2-Bromonaphthalen-6-yloxy)methyl)-1-allyl-1H-1,2,3-triazole
4-((2-Bromonaphthalen-6-yloxy)methyl)-1-isobutyl-1H-1,2,3-triazole
4-((Benzo[d]thiazol-2-ylimino)methyl)phenol
4-(3,5-dichlorophenoxy)-N'-hydroxy-3-nitro-benzamidine
4-(3-chlorophenyl)-5-[2-(2-hexoxyethoxy)ethyl]benzene-1,3-diamine
4-(Tert-butyl)-N-(4-(((2,4-diaminoquinazolin-6-yl)amino) methyl)phenethyl)cyclohexane-1-carboxamide
4',5'-dibromo-2',7'-dinitrofluorescein
4-Amino-N-{1-[3-(3-chlorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]-3-methylbutyl}-benzenesulfonamide
4-Amino-N-{1-[3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]-3-methylbutyl}-benzenesulfonamide
4-Amino-N-{1-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]-3-methylbutyl}-benzenesulfonamide
5-fluoroorotate
5-Fluoroorotate
5-fluorouridine
5-heptyl-4-phenyl-benzene-1,3-diamine;5-hexyl-4-phenyl-benzene-1,3-diamine
6-(m-tolyl)-5,6,7,8-tetrahydroquinazoline-2,4-diamine
6-[4-[2-[(7-chloro-4-quinolyl)amino]ethyl]piperazin-1-yl]-N4-(4-methoxyphenyl)-N2-(4-nitrophenyl)-1,3,5-triazine-2,4-diamine
Ag331
Aminopterin
Antibodies inhibit invasion
Aza-acyclic nucleoside phosphonates
Benzyl 3-(2,6-diamino-5-(3-chlorophenyl)pyrimidin-4-yl)propyl carbonate
Carboxamide
Cd00706
Chlorcycloguanil
Chloroquine
Clociguanil
Coelenterazine
Comparative molecular field analysis, suggested target
Cycloguanil
Cycloguanil
Dapsone
Daunorubicin
Dihydrotriazine
Eosin b
Floxuridine
Fluorouracil
Furo[2,3-d]pyrimidine
Furo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine
Gk03628
Gk03630
Glms ribozyme
Gw8510
Hybrid phenylthiazolyl-1,3,5-triazine derivatives
Jpc-2056
Maybridge2004
Methotrexate
N-(4-(((2,4-Diaminoquinazolin-6-yl)amino)methyl) phenethyl)cyclohexanecarboxamide
N-(4-amino-6-((4-hydroxyphenyl)amino)-1,3,5-triazin-2-yl)- 4-(2-((7-chloroquinolin-4-yl)amino)ethyl)piperazine-1- carbothioamide
N-(4-amino-6-((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)-4- (2-((7-chloroquinolin-4-yl)amino)ethyl)piperazine-1- carbothioamide
N-(5-bromo-2-pyridyl)-4-methyl-2-[3-(4-nitrophenyl)-1-phenyl-4H-pyrazol-4-yl]-6-oxo-2,5-dihydro-1H-pyridine-3-carboxamide
N-(5-bromo-2-pyridyl)-4-methyl-6-oxo-2-[1-phenyl-3-(p-tolyl)-4H-pyrazol-4-yl]-2,5-dihydro-1H-pyridine-3-carboxamide
N-(5-bromo-2-pyridyl)-7-[3-(4-chlorophenyl)-1-phenyl-pyrazol-4-yl]-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide
N-(5-bromo-2-pyridyl)-7-[3-(4-fluorophenyl)-1-phenyl-pyrazol-4-yl]-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide
N-(benzo[d]thiazol-2-yl)-1-(3-nitrophenyl)methanimine
N-(benzo[d]thiazol-2-yl)-1-(4-bromophenyl)methanimine
N-(benzo[d]thiazol-2-yl)-1-(4-chlorophenyl)methanimine
N1-(3-((7-chloroquinolin-4-yl)amino)propyl)-N2-(2-(diethylamino)ethyl)oxalamide
N1-(7-chloroquinolin-4-yl)-N3-(furan-2-ylmethyl)-N3-(6-methyl-2-morpholinopyrimidin-yl)propane-1,3-diamine
N1-(Benzo[d][1,3]dioxol-5-ylmethyl)-N2-(7-chloroquinolin- 4-yl)-N1-(2-(4-ethylpiperazin-1-yl)-6-methylpyrimidin-4-yl) ethane-1,2-diamine
N1-(Benzo[d][1,3]dioxol-5-ylmethyl)-N3-(7-chloroquinolin- 4-yl)-N1-(6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl)propane-1,3- diamine
N2-(2-(7-chloroquinolin-4-ylamino)ethyl)-N4 ,N6 -dimethyl-1,3,5- triazine-2,4,6-triamine
N2-(2-(7-chloroquinolin-4-ylamino)ethyl)-N4 -methyl-6- (piperidin- 1-yl)-1,3,5-triazine-2,4-diamine
N2-(2-(7-chloroquinolin-4-ylamino)ethyl)-N4,N4 -dimethyl-1,3,5- triazine-2,4,6-triamine
N2-(2-(7-chloroquinolin-4-ylamino)ethyl)-N4,N6-dipropyl-1,3,5-triazine-2,4,6-triamine
Nci00043568
Nci00129588
Nci0014710
Nci0027612
Nci0029604,
Nci0037722
Nci2000
Nitro bt
P218
Phenoxypropoxybiguanide
Pyrimethamine
Pyrimethamine analogs p1, p30, p38, p20, p36, p34, and p64
Pyrrolo[2,3-d]pyrimidine
Qsar models, 2,4,6-trisubstituted-s-triazine
Qsar using evolved neural networks, pyrimethamine derivatives
Quinazoline
Rjf 001302
Rjf 00670
Rjf00719
S-benzylated guanylthiourea
Soulameanone
Sti-571
Suggested target
Sulfadoxine
Tcmdc-139863
Tetracycline
Tetrahydroquinazoline
Tigecycline
Translational inhibition, suggested target
Triclosan
Trimethoprim
Trimethoprim analogs
U-74389g
Wr99210
WS9326A