You can find more information about PF3D7_1012400-HGXPRTase using the following links:

PlasmoDB - the Plasmodium genome resource
The TDR Targets Database

Subcellular Localization

PDB protein strucure

Affecting Drugs
Drug Name PubMed Articles (year of publication)
(1s)-1-(9-deazaguanin-9-yl)-1,4-dideoxy-1,4- imino-d-ribitol 5-phosphate
(1s)-1-(9-deazahypoxanthin-9- yl)-1,4-dideoxy-1,4-imino-d-ribitol 5-phosphate
(2-((2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl)(2-(2-phosphonoethoxy)ethyl)amino)ethyl)phosphonic acid
(2S,2' S)-Diethyl 2,2' -{[2-((2-(guanin-9-yl)ethyl)(3-methoxy-3-oxopropyl)amino)ethyl]phosphoryl}bis(azanediyl)bis(3- phenylpropanoate)
(2S,2' S)-Diethyl 2,2' -{[2-((2-(guanin-9-yl)ethyl)(4-methoxy-4-oxobutyl)amino)ethyl]phosphoryl}bis(azanediyl)bis(3- phenylpropanoate)
(2S,2' S)-Diethyl 2,2' -{[2-((3-methoxy-3-oxopropyl)(2- (hypoxanthin-9-yl)ethyl)amino)ethyl]phosphoryl}bis(azanediyl)bis(3-phenylpropanoate)
(2S,2' S)-Diisopropyl 2,2' -{[2-((2-(benzyloxy)ethyl)(2- (guanin-9-yl)ethyl)amino)ethyl]phosphoryl}bis(azanediyl)- bis(3-phenylpropanoate)
(2S,2' S)-Diisopropyl 2,2' -{[2-((2-(benzyloxy)ethyl)(2- (hypoxanthin-9-yl)ethyl)amino)ethyl]phosphoryl}bis(azanediyl)bis(3-phenylpropanoate)
(3-(4-(2-Hydroxyethyl)-5-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-1H-1,2,3- triazol-1-yl)propyl)phosphonic acid
(3-(5-(4-Oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)propyl) phosphonic acid
(S)-(2-((1-Hydroxy-3-(hypoxanthin-9-yl)propan-2-yl)oxy)ethyl)- phosphonic acid
(S)-(2-((Guanin-9-yl)-3-hydroxypropan-2-yl)oxy)ethyl) phosphonic acid
(S)-(4-hydroxy-3-(((4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)butyl)phosphonate
(s)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]guanine
[3-(guanine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methylphosphonic acid
{[(2-((guanine-9-yl)methyl)propane-1,3-diyl)bis (oxy)]bis(ethylene)}diphosphonic acid
{[(2-(guanine-9-yl)propane-1,3-diyl)bis(oxy)]bis (ethane-2,1-diyl)}diphosphonic acid
{[(2-[(guanin-9-yl)methyl]-propane-1,3-diyl)bis(oxy)]bis (methylene)}diphosphonic acid
{[(2-[(guanine-9hyl)methyl]propane-1,3-diyl)bis(oxy)]bis(methylene)}diphosphonic acid
{2-[2-(6-Oxo-1,6-dihydro-9H-purin-9-yl)ethoxy]propan-2-yl}phosphonic acid (19a)
2-(phosphonoethoxy)ethylguanine
2-amino-6-chloropurine
3-fluoro-(2-phosphonoethoxy)propyl
4-((((S)-2,2-dimethylcyclopentane-1-carbonyl)oxy)methyl)tetrahydro-2H-pyran-3-carboxylic acid
6-chloroguanine
6-mercaptopurine
6-thioguanine
6-thioxanthine
8-azaguanine
8-azahypoxanthine
9-[2-(2-phosphonoethoxy)ethyl] hypoxanthine
9-[2-(2-phosphonoethoxy)ethyl]guanine;
9-[2-(2-phosphonoethoxy)ethyl]purines
9-deazaguanine
9-deazahypoxanthine
9-phosphonoalkoxyalkyl
9-phosphonoalkyl
Allopurinol
antisense oligodeoxynucleotides
Aza-acyclic nucleoside phosphonates
Aza-c-nucleosides
azetidin
Bestatin
Biochemical characterization, suggested target
Curcumin
Diethylpyrocarbonate
Dsm59
FPMP
Furan
Hpmpg
Immucillin G
immucillin GP
Immucillin H
Immucillin HP
Membrane potetial, ion composition
Peeg
PEEHx
Phosph(on)ates
Phosphonate
pyrrolidine
Serinol
Sodium 1-Hydroxy-5-(guanin-9-yl)-3-oxapentanphosphonate
Suggested target
Tetra-(ethyl L-phenylalanine) prodrug of 9-[(N,N-(bis-2- phosphonoethyl))-2-aminoethyl]hypoxanthine