Production of cAMP in P. falciparum merozoites by adenylyl cyclase b (PfACb) and microneme exocytosis. A) Expression of PfACb in P. falciparum blood stages. Immunofluorescence assays (IFA) were used to detect PfACb (green) in P. falciparum rings (i), trophozoites (ii), schizonts (iii) and merozoites (iv) using mouse antisera against a peptide derived from PfACb. Nuclear DNA was stained with DAPI (blue). Rabbit antiserum against P. falciparum cytoplasmic protein PfNAPL (red) was used for co-localization. Yellow indicates overlap of PfACb and PfNAPL
Dawn A, Singh S, More KR, Siddiqui FA, Pachikara N, Ramdani G, Langsley G, Chitnis CE. The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes. PLoS Pathog. 2014 Dec 18;10(12):e1004520. PMID: 25522250
Other associated proteins
PFID | Formal Annotation |
---|---|
PF3D7_1203700 | nucleosome assembly protein |