Co-localization of SR10 with the ER-resident ERC. Trophozoites (TZ), schizonts (SZ) and gametocytes (GCIII, GCV) of the SR10-HA line were immunolabelled with rabbit anti-HA antibody (green). The parasites were counterlabelled with mouse anti-ERC antisera (red) and parasite nuclei were highlighted by Hoechst33342 nuclear stain (blue). Bar, 5 μm. IFAs, using the SR10-HA-expressing line, demonstrated a partial co-localization of SR10 (using rabbit anti-HA antibodies) and ERC (using mouse anti-ERC antisera).

Njila Tchoufack EJ, Hahnfeld L, Pitschelatow G, Bennink S, Pradel G. The endoplasmic reticulum-resident serpentine receptor SR10 has important functions for asexual and sexual blood stage development of Plasmodium falciparum. Mol Biochem Parasitol. 2020 Sep 2:111315.