Comparison of the vacuolar translocation and transport pathways in Plasmodium. Effector protein translocation is mediated by the PTEX complex. u and r indicate unfolding and refolding steps prior to and after translocation. PF3D7_1105600 PTEX subunit EXP2, in association with another vacuolar membrane protein PF3D7_1121600 EXP1, is involved in the transport of small molecules across the membrane; this activity seems independent from the protein secretion activity. Egea PF. Crossing the Vacuolar Rubicon: Structural Insights into Effector Protein Trafficking in Apicomplexan Parasites. Microorganisms. 2020 8(6):865. PMID: 32521667

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