RNA-sequencing platforms (red) contribute to the identification of distinct transcriptomic signatures across the different life stages of Plasmodium. These gene expression patterns define cell function(s) and are under the controlof master ApiAP2 transcription factors. Nucleosome occupancy and histone modifications (blue) are major factors regulating chromatin condensation. Other epigenetic mechanisms include lncRNAs and DNA methylation patterns (orange). Finally, the overall chromatin landscape is well organized, forming a repressive cluster including telomeres and var genes positioned at opposing poles of centromeres within the nucleus (green). Abbreviations: ApiAP2, apicomplexan Apetala2; HP1, heterochromatin protein 1; lncRNA, long noncoding RNA; RNAP, RNA polymerase; scRNA-seq, single-cell RNA sequencing

Hollin T, Chahine Z, Le Roch KG. Epigenetic Regulation and Chromatin Remodeling in Malaria Parasites. Annu Rev Microbiol. 2023 77:255-276. PMID: 37268002.