Model of SG assembly and disassembly. Upon RNA influx, key SG node and bridge proteins form a multi interaction network, which causes LLPS and the assembly of SGs. Following stress removal, PTMs potentially lead to the loss of protein-protein, protein-RNA, and RNA-RNA interactions, leading to a decrease in valence and allowing subsequent SG disassembly. Hofmann S, Kedersha N, Anderson P, Ivanov P. Molecular mechanisms of stress granule assembly and disassembly. Biochim Biophys Acta Mol Cell Res. 2021 1868(1):118876. doi: 10.1016/j.bbamcr.2020.118876. Epub 2020 Sep 29. PMID: 33007331