PF3D7_0101500 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene

G3BP1 conformation affects its role in the cell. (a) G3BP1 functions in ribosomal quality control and stress granule assembly. In the closed conformation (blue), G3BP1 is phosphorylated and IDR1 acts as an autoinhibitory element to block the RNA recognition motif (RRM) from binding high concentrations of RNA. In the open conformation (red), G3BP1 is dephosphorylated, and the RRM binds RNA and can undergo liquid–liquid phase separation related to stress granule formation. (b) G3BP1 functions in axonal mRNA translation are illustrated. Specifically, G3BP1 is part of granules when the serines are dephosphorylated in combination with HuR, TIA‐1, and FMR1. When G3BP1 becomes phosphorylated, the granules disassemble and select mRNAs are translated in the axon. (c) G3BP1 function in structure‐mediated decay. Sidibé H, Dubinski A, Vande Velde C. The multi-functional RNA-binding protein G3BP1 and its potential implication in neurodegenerative disease. J Neurochem. 2021 157(4):944-962.

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