The P. falciparum tRNA modification profile changes dynamically throughout parasite development and in response to different stressors. a) Abundances of Am and S2U in P. falciparum tRNA decrease as parasites progress through the IDC, while 22 other modifications show the opposite trend. b) Levels of various tRNA modifications change differentially in response to a 6 hr treatment of various chemical and environmental stressors at varying concentrations at the trophozoite stage. Lee BST, Sinha A, Dedon P, Preiser P. Charting new territory: The Plasmodium falciparum tRNA modification landscape. Biomed J. 2024 9:100745. PMID: 38734409.