Biological binding and functional validation of 11 SBP1 interactors by use of immunofluorescence (D) assays on endogenous SBP1-FLAG cells. Scale bar, 3 mm. The ratio of co-localization between two factors was analyzed by using Python 3.7.3 and is shown as the mean G±SD (n = 10). six of the parasite proteins (PIESP2, REX1, REX2, MAHRP1, STEVOR, and TryThrA) co-localized with SBP1 in the Maurer’s clefts, whereas the remaining five proteins (two parasite proteins, PF10_0018 and MAHRP2, and three host proteins, STOM, KPNB1, and MPP1) showed partial co-localization with SBP1,
Sherling ES, Perrin AJ, Knuepfer E, Russell MRG, Collinson LM, Miller LH,Blackman MJ. The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion PLoS Pathog. 2019 15(9):e1008049.
Other associated proteins
PFID | Formal Annotation |
---|---|
PF3D7_0501300 | skeleton-binding protein 1 |
PF3D7_0935900 | ring-exported protein 1 |
PF3D7_0936000 | ring-exported protein 2 |
PF3D7_1001400 | exported lipase 1 |
PF3D7_1353200 | membrane associated histidine-rich protein 2 |
PF3D7_1370300 | membrane associated histidine-rich protein |
STEVOR | STEVOR |