PF3D7_1301700 cx3cl1-binding protein 2, gametocyte exported protein 7, GEXP7

Maurer’s cleft proteins interact to form distinct protein clusters. (A and B) Protein interaction maps highlighting a putative PfEMP1 loading hub comprising GEXP07, MAHRP1, and GEXP10 (A) and a putative unloading hub comprising REX1, PTP5, SEMP1, and PF3D7_1353100 (B). Green nodes represent the GFP-tagged proteins. Double-thickness edges indicate reciprocal co-precipitation (see Fig. S3 for full-network maps). (C) 3D-SIM analysis of REX1-GFP-infected RBCs fixed and labeled with anti-GFP (green) and anti-MAHRP1 (red). (D to G) 3D-SIM analysis of transfectant-infected RBCs expressing GFP-tagged GEXP07, GEXP10, PTP5, and Pf3D7_1353100 that were fixed and labeled with anti-GFP (green) and anti-REX (red) antibodies. Maximum projections of Z-stacks are displayed. Scale bars = 3 μm, zoom scale bar = 3 μm. Omoda A, Matsumoto K, Yoshino KI, Tachibana M, Tsuboi T, Torii M, Ishino T, Iriko H. Skeleton binding protein 1 localizes to the Maurer's cleft and interacts with PfHSP70-1 and PfHSP70-x in Plasmodium falciparum gametocyte-infected erythrocytes. Parasitol Int. 2024 100:102864. PMID: 38331312.

Other associated proteins

PFID Formal Annotation
PF3D7_1370300 membrane associated histidine-rich protein
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