Genetic knockout of GEXP07 led to a loss of PfEMP1 at the RBC surface and impaired adhesion. (A) Wild-type CS2 and GEXP07 knockout-infected RBCs were fixed and probed with anti-PfEMP1 (green) and counter stained with anti-REX1 (red). Nuclei were stained with DAPI (blue). CS2 = parent line. Projections of Z stacks are shown. Scale bar = 5 μm. McHugh E, Carmo OMS, Blanch A, Looker O, Liu B, Tiash S, Andrew D, Batinovic S, Low AJY, Cho HJ, McMillan P, Tilley L, Dixon MWA. Role of Plasmodium falciparum Protein GEXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking. mBio. 2020 11(2):e03320-19. PMID: 32184257
PubMed Article: Role of Plasmodium falciparum Protein GEXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking
Other associated proteins
PFID | Formal Annotation |
---|---|
PF3D7_0100300 | erythrocyte membrane protein 1, PfEMP1 |
PF3D7_0115700 | erythrocyte membrane protein 1, PfEMP1 |
PF3D7_0712000 | erythrocyte membrane protein 1, PfEMP1 |
PF3D7_0935900 | ring-exported protein 1 |