SERA6 and its partner MSA180 form transient multimolecular aggregates during egress. Representative IFA images demonstrating localisation of MSA180-HA3 during egress. MSA180-HA3 [B11] schizonts were sampled at the indicated times following removal of C2-arrest, fixed and co-stained with DAPI (blue), anti-HA (red) and anti-ankyrin (green). Scale bar, 5 mm. Observation that the SERA6-MSA180 aggregates partly co-localise with the cytoskeletal protein ankyrin is particularly exciting as it aligns with the proposed role of SERA6 in cleaving key RBC cytoskeletal proteins to mediate RBCM rupture during egress.
Tan MSY, Koussis K, Withers-Martinez C, Howell SA, Thomas JA, Hackett F, Knuepfer E, Shen M, Hall MD, Snijders AP, Blackman MJ. Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor. EMBO J. 2021 1:e107226.
Other associated proteins
PFID | Formal Annotation |
---|---|
PF3D7_1014100 | merozoite surface protein msa180 |