Localization of Pf AMA1, RON2, and RON4 at the moving junction of invading merozoites. Confocal microscopy images of merozoite invading RBC are shown. (A) Pf AMA1, RON2, and RON4 colocalize during invasion. (B) AMA1 is present at the moving junction (Top) with RON4 colocalizing with AMA1 at the junction (Middle). RON4 marks the sealing of the junction after invasion (Bottom). Scale bars represent 1μM.
Schematic model of the steps involved in Pf merozoite (Mrz) invasion.
Srinivasan P, Beatty WL, Diouf A, Herrera R, Ambroggio X, Moch JK, Tyler JS, Narum DL, Pierce SK, Boothroyd JC, Haynes JD, Miller LH. Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion. Proc Natl Acad Sci U S A. 2011 108(32):13275-80
PubMed Article: Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
Other associated proteins
PFID | Formal Annotation |
---|---|
PF3D7_0930300 | merozoite surface protein 1 |
PF3D7_1116000 | rhoptry neck protein 4 |