PF3D7_1230700 protein transport protein SEC13

Dynamics of PfSec13-GFP during P. falciparum intra erythrocytic development. High resolution microscopy (3D-SIM) of PfSec13-GFP showing an increase in the number of foci as parasites develop into trophozoites (1- 30 hpi) and a gradual decrease during schizogony (36 and 48 hpi). The high resolution of these images enables differentiation between the large strong signals and the fainter ones. The size bar represents 2 μm for 1, 16, 24, 38 & 48 hpi and 1 μm for 30 hpi. Using super resolution microscopy it is possible to differentiate between strong signals at the nuclear periphery and weaker signals seen in the cytoplasm.

Dahan-Pasternak N, Nasereddin A, Kolevzon N, Pe'er M, Wong W, Shinder V, Turnbull L, Whitchurch CB, Elbaum M, Gilberger TW, Yavin E, Baum J, Dzikowski R. PfSec13 is an unusual chromatin associated nucleoporin of Plasmodium falciparum, which is essential for parasite proliferation in human erythrocytes. J Cell Sci. 2013 126(Pt 14):3055-69 Reproduced with permission.

img