PfERC is not required for protein trafficking or organellar biogenesis. (A) Representative SIM images of PfERC-glmS and PfERC-M9 schizonts incubated with GlcN for 48 h and stained with anti-MSP1 and the nuclear stain DAPI. From top to bottom, the images are DAPI (blue), anti-MSP1 (green), and fluorescence merge. Bar, 2 μm. (C) Representative SIM images of PfERC-glmS and PfERC-M9 schizonts incubated with GlcN for 48 h and stained with anti-RAP1 and the nuclear stain DAPI. From top to bottom, the images represent DAPI (blue), anti-RAP1 (green), and fluorescence merge. Bar, 2 μm.

Fierro MA, Asady B, Brooks CF, Cobb DW, Villegas A, Moreno SNJ, Muralidharan V. An Endoplasmic Reticulum CREC Family Protein Regulates the Egress Proteolytic Cascade in Malaria Parasites. mBio. 2020 11(1):e03078-19. PMID: 32098818