Sir2 and Orc1 relocalize during the developmental cycle of P. falciparum. (B-D) IF analysis of Sir2 (green) and Orc1 (red) during the blood-stage cycle. (B) Ring stages display a punctate pattern at the nuclear periphery. (C) In the trophozoite stages, anti-Sir2 and -Orc1 antibodies reveal an apparent increase of both protein levels, and an additional punctate and diffuse pattern inside and outside of the nucleus. (D) The schizont stage, Sir2 and Orc1 seem to relocalize at the nuclear periphery.

Mancio-Silva L, Rojas-Meza AP, Vargas M, Scherf A, Hernandez-Rivas R. Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum. J Cell Sci. 2008 121:2046-53.