Localization of SE5 P1 and SE5 P2 peptides with PfSERA5. a) The biotinylated peptides SE5 P1 and SE5 P2 were allowed to incubate with the mature blood stage parasites. The parasite was then probed for biotinylated peptides (green) and PfSERA5 (red). Parasite nuclei were stained with DAPI, a nuclear dye (blue). On superimposing, the areas of colocalization were seen as yellow. SE5 P1 and SE5 P2 were seen to be colocalized with the PfSERA5 within the parasitophorous vacuole.

Kanodia S, Kumar G, Rizzi L, Pedretti A, Hodder AN, Romeo S, Malhotra P. Synthetic peptides derived from the C-terminal 6kDa region of Plasmodium falciparum SERA5 inhibit the enzyme activity and malaria parasite development. Biochim Biophys Acta. 2014 25;1840(9):2765-2775. PMID: