PF3D7_0709000 chloroquine resistance transporter

Co-localization of PfExp-1 and PfABCG in P. falciparum-infected erythrocytes. Double immuno-histochemical staining of infected erythrocytes at trophozoites stage with antibodies against PfABCG and PfExp-1 (Panel A) and PfCRT and PfExp-1 (Panel B). Column 1 shows the nuclear DNA staining with DAPI (blue). In columns 2 and 3, PfABCG signal (green) (A) and PfCRT signal (green) (B) are resolved with Alexa-fluor 488-labeled goat anti-rabbit secondary antibody, and PfExp-1 signal (red) (A and B) is resolved with Alexa-fluor 594-labeled goat anti-rabbit secondary antibody. Columns 4 and 5 show respectively the differential interference contrast (DIC) of infected erythrocyte and the merger of column 1, 2 and 3 without DIC. The digestive vacuole membrane staining of PfCRT does not overlap with PfExp-1 staining while the plasma membrane staining of PfABCG partially overlaps with the parasitophorous vacuole membrane signal of PfExp-1 as indicated by the arrow.

Edaye S, Georges E. Characterization of native PfABCG protein in Plasmodium falciparum. Biochem Pharmacol. 2015 Jul 31. [Epub ahead of print] PMID:

PubMed Article: Characterization of native PfABCG protein in Plasmodium falciparum.

Other associated proteins

PFID Formal Annotation
PF3D7_1121600 parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen
PF3D7_1426500 ABC transporter G family member 2
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