PfTRZ is required for proliferation and telomere length homeostasis. a, Co-localization of PfTRZ and PfHP1 in 3D7/TRZGFP, 3D7/TRZGFP-ON

(+Shield-1) and 3D7/TRZGFP-OFF (−Shield-1) trophozoites. White frames refer to the magnified view in the rightmost images. Scale bar, 5 μm. Results are representative of three biological replicate experiments. PfTRZ-GFP-DD displayed the expected perinuclear expression pattern in 3D7/TRZGFP-ON parasites, but was barely detectable in parasites cultured in the absence of Shield-1 (3D7/TRZGFP-OFF).

Bertschi NL, Toenhake CG, Zou A, Niederwieser I, Henderson R, Moes S, Jenoe P, Parkinson J, Bartfai R, Voss TS. Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA. Nat Microbiol. 2017 2:17033.