Analysis of the GBP130 N-terminal region. Live cell imaging (lower panel) of parasites expressing GBP1-47 fused to GFP reveals that this region contains no targeting information. Right panel: Mutations within, or deletion of the transition areas have no effect on protein entry to the secretory system. DIC, differential interference contrast; GFP, green fluorescent protein; Hoechst, nuclear staining. In merge and overlay: green, GFP; blue, Hoechst

Meyer C, Barniol L, Hiss JA, Przyborski JM. The N-terminal extension of the P. falciparum GBP130 signal peptide is irrelevant for signal sequence function. Int J Med Microbiol. 2017 S1438-4221(17)30195-9.