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Genes coding for Fe-S containing proteins |
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Swift RP, Rajaram K, Elahi R, Liu HB, Prigge ST. Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparum Parasites. mBio. 2022 Feb 15:e0302321. PMID: 35164549. |
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PfID |
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Annotation |
Signal peptide |
Transit peptide |
P. falciparum1 |
P. falciparum (This study) |
E.C |
Transcript |
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PF3D7_1344600 |
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lipoyl synthase |
++ |
++ |
Essential |
Dispensable |
2.8.1.8 |
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| 28190 |
PF3D7_0921400 |
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NifU-like scaffold protein |
++ |
++ |
Essential |
Dispensable |
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| 28188 |
PF3D7_1103400 |
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sulfur cluster assembly protein SufD |
++ |
++ |
Essential |
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| 28187 |
PF3D7_716600 |
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++ |
++ |
Slow/ Dispensable |
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| 28168 |
PF3D7_522700 |
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++ |
++ |
Essential |
Dispensable |
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| 28170 |
PF3D7_1318100 |
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ferredoxin, putative |
++ |
++ |
Slow/ Dispensable |
Essential |
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| 28184 |
PF3D7_910800 |
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++ |
++ |
Slow |
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PF3D7_622200 |
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+ |
++ |
Dispensable |
Dispensable |
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| 28197 |
PF3D7_1022800 |
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4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative |
+ |
++ |
Essential |
Essential |
1.17.7.1 |
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| 28177 |
PF3D7_910900 |
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- |
++ |
Essential |
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PF3D7_1342100 |
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aconitate hydratase |
- |
++ |
Slow/ Dispensable |
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4.2.1.3 |
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| 28194 |
PF3D7_1214600 |
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adrenodoxin-type ferredoxin, putative |
- |
++ |
Slow/ Essential |
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| 28174 |
PF3D7_1454500 |
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iron-sulfur cluster assembly protein ISCU |
- |
++ |
Essential |
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| 28173 |
PF3D7_207200 |
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- |
++ |
Essential |
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| 28179 |
PF3D7_727200 |
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- |
++ |
Slow/ Essential |
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| 28193 |
PF3D7_720400 |
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- |
++ |
Dispensable |
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| 28167 |
PF3D7_614800 |
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- |
++ |
Dispensable |
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| 28178 |
PF3D7_1220500 |
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ribosome biogenesis protein TSR3, putative |
- |
++ |
Essential |
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| 28199 |
PF3D7_1361600 |
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Fe-S assembly protein iscx, putative |
- |
++ |
Essential |
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| 28198 |
PF3D7_1439400 |
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cytochrome b-c1 complex subunit Rieske, putative |
- |
++ |
Dispensable |
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1.10.2.2 |
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| 28181 |
PF3D7_927300 |
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- |
++ |
Essential |
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| 28183 |
PF3D7_1212800 |
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succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
- |
++ |
Dispensable |
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1.3.99.1 |
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| 28171 |
PF3D7_709200 |
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- |
++ |
Dispensable |
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| 28167 |
PF3D7_416700 |
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- |
++ |
Dispensable |
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| 28169 |
PF3D7_930900 |
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- |
++ |
Dispensable |
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| 28186 |
PF3D7_1306300 |
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SAM dependent methyltransferase, putative |
- |
++ |
Dispensable |
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2.1.1.35 |
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| 28191 |
PF3D7_API04700 |
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iron-sulfur cluster assembly protein SUFb |
- |
++ |
ND |
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| 28182 |
PF3D7_1472700 |
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DNA-directed RNA polymerase, alpha subunit, putative |
+ |
+ |
Essential |
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2.7.7.6 |
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| 34026 |
PF3D7_1406900 |
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radical SAM protein, putative |
- |
+ |
Essential |
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| 28192 |
PF3D7_322500 |
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- |
+ |
Dispensable |
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| 28180 |
PF3D7_104400 |
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- |
- |
Dispensable |
Essential |
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PF3D7_1017000 |
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DNA polymerase delta catalytic subunit |
- |
- |
Essential |
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2.7.7.7 |
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| 28175 |
PF3D7_934100 |
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- |
- |
Essential |
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| 28172 |
PF3D7_1128500 |
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Fe-S cluster assembly factor hcf101, putative |
- |
- |
Essential |
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| 28189 |
PF3D7_1227800 |
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elongator complex protein 3, putative |
- |
- |
Slow/ Dispensable |
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2.3.1.48 |
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| 28195 |
PF3D7_1022900 |
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COX13 CDGSH iron-sulfur domain-containing protein, putative |
- |
- |
Dispensable |
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| 28185 |
PF3D7_0524900 |
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S-adenosyl-l-methionine-dependent trna 4-demethylwyosine synthase, putative |
- |
- |
Dispensable |
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4.1.3.44 |
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| 28176 |
PF3D7_1458700 |
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exonuclease V, mitochondrial, putative |
- |
- |
Essential |
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3.1.11.5 |
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PF3D7_1238800 |
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acyl-CoA synthetase |
- |
- |
Essential |
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6.2.1.3 |
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PF3D7_1435300 |
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glutamate synthase [NADH], putative |
- |
- |
Dispensable |
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1.4.1.14 |
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PF3D7_606900 |
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- |
- |
Essential |
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PF3D7_1408400 |
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FANCJ-like helicase, putative |
- |
- |
Essential |
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3.6.4.12 |
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PF3D7_1143300 |
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DNA-directed RNA polymerases I and III subunit RPAC1, putative |
- |
- |
Essential |
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2.7.7.6 |
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PF3D7_515800 |
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- |
- |
Essential |
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PF3D7_1415200 |
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DNA-directed RNA polymerases I and III subunit RPAC2, putative |
- |
- |
Essential |
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2.7.7.6 |
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PF3D7_1413800 |
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diphthamide biosynthesis protein 1, putative |
- |
- |
Slow/ Dispensable |
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6.3.2.22 |
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PF3D7_923000 |
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- |
- |
Essential |
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PF3D7_614200 |
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- |
- |
Essential |
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PF3D7_1324500 |
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DEAD box helicase, putative |
- |
- |
Essential |
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PF3D7_302700 |
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- |
- |
Essential |
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PF3D7_1129500 |
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A/G-specific adenine glycosylase, putative |
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- |
Dispensable |
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3.2.2.20 |
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PF3D7_306300 |
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- |
- |
Essential |
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PF3D7_824600 |
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- |
- |
Essential |
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PF3D7_1368200 |
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ABC transporter E family member 1, putative |
- |
0 |
Essential |
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1. Zhang M, Wang C, Otto TD, Oberstaller J, Liao X, Adapa SR, Udenze K, Bronner IF, Casandra D, Mayho M, Brown J, Li S, Swanson J, Rayner JC ,Jiang RHY, Adams JH. 2018. Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis. Science 360:eaap7847. |
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