Malaria Parasite Metabolic Pathways
Drugs affecting pathway with unknown specific target
| Drug Name | PubMed Articles (year of publication) |
|---|---|
| Daphnetin | |
| Ferrichrome | |
| formylbenzoic acid | |
| glyoxylic acid | |
| Monocatecholate | |
| phenylglyoxylic acid | |
| tris-aminopropyl-methyl-D-glucopyranoside |
Mechanism of Fe–S-protein biogenesis map details
| PFID | PFID Old | Annotation | Formal Annotation | EC | Transcript |
|---|---|---|---|---|---|
PF3D7_1208300
|
PFL0415w | acyl carrier protein, mitochondrial | acyl carrier protein, mitochondrial |
|
|
PF3D7_1352100
|
PF13_0271 | Atm1 | ABC transporter B family member 6, putative, ABCB6 |
|
|
|
PF3D7_0302700
|
PFC0126c | CDGSH | CDGSH iron-sulfur domain-containing protein, putative |
|
|
| PF3D7_0416700 | PFD0807c | CDGSH | CDGSH iron-sulfur domain-containing protein, putative |
|
|
| PF3D7_1022900 | PF10_0222 | CDGSH | COX13 CDGSH iron-sulfur domain-containing protein, putative |
|
|
| PF3D7_1324500 | MAL13P1.134 | Chap ADP | DEAD box helicase, putative |
|
|
|
PF3D7_0716600
|
PF07_0068 | Cysteine desulfurase | cysteine desulfurase | 2.8.1.7 |
|
|
PF3D7_0727200
|
MAL7P1.150 | Cysteine desulfurase | cysteine desulfurase ISCS | 2.8.1.7 |
|
|
PF3D7_1311000
|
MAL13P1.53 | Cysteine desulfurase | protein ISD11, putative | 2.8.1.7 |
|
| PF3D7_1209400 | PFL0470w | cytosolic iron-sulfur protein assembly protein 1 | cytosolic iron-sulfur protein assembly protein 1, putative |
|
|
| PF3D7_0824600 | MAL8P1.31 | Dre2-like protein | Fe-S cluster assembly protein DRE2, putative |
|
|
| PF3D7_0720400 | PF07_0085 | Ferredoxin-NADP+ reductase | ferrodoxin reductase-like protein | 1.18.1.2 |
|
| PF3D7_1139700 | PF11_0407 | Ferredoxin-NADP+ reductase | adrenodoxin reductase, putative | 1.18.1.2 |
|
|
PF3D7_0304500
|
PFC0205c | Glutaredoxine | 1-cys-glutaredoxin-like protein-1 | 1.11.1.15 |
|
|
PF3D7_1124700
|
PF11_0258 | GRPE | GrpE protein homolog, mitochondrial, putative |
|
|
| PF3D7_0816500 | MAL8P1.78 | HSP20 | small heat shock protein HSP20, putative |
|
|
| PF3D7_0920100 | PFI0985c | HSP20 | chaperone, putative |
|
|
|
PF3D7_0818900
|
PF08_0054 | HSP70 | PfHsp70-1 |
|
|
|
PF3D7_1134000
|
PF11_0351 | HSP70 | PfHsp70-3 |
|
|
| PF3D7_0207200 | PFB0320c | ISCA | iron-sulfur assembly protein, putative |
|
|
| PF3D7_0322500 | PFC1005c | ISCA | iron-sulfur assembly protein, putative |
|
|
| PF3D7_1361600 | MAL13P1.307 | ISCX | Fe-S assembly protein iscx, putative |
|
|
| PF3D7_1454500 | PF14_0518 | ISU | iron-sulfur cluster assembly protein ISCU |
|
|
| PF3D7_0505000 | PFE0245c | MMS19 | mms19-like protein, putative |
|
|
| PF3D7_0905200 | PFI0255c | Mrs3/4 | mitochondrial carrier protein, putative |
|
|
| PF3D7_0930900 | PFI1835c | NFU | NifU-like protein, putative |
|
|
|
PF3D7_0921400
|
PFI1050c | NiFU | NifU-like scaffold protein |
|
|
| PF3D7_1128500 | PF11_0296 | NTPase | Fe-S cluster assembly factor hcf101, putative |
|
|
| PF3D7_0910800 | PFI0525w | NTPase with ISC domain | cytosolic Fe-S cluster assembly factor NBP35, putative |
|
|
| PF3D7_1214600 | PFL0705c | Reduced ferredoxin | adrenodoxin-type ferredoxin, putative |
|
|
| PF3D7_1318100 | MAL13P1.95 | Reduced ferredoxin | ferredoxin, putative |
|
|
|
PF3D7_0522700
|
PFE1135w | SUFA | iron-sulfur cluster assembly protein SUFA |
|
|
|
PF3D7_1413500
|
PF14_0133 | SUFC | ABC transporter I family member 1 FeS assembly ATPase SufC |
|
|
|
PF3D7_1103400
|
PF11_0044 | SUFD | sulfur cluster assembly protein SufD |
|
|
|
PF3D7_0206100
|
PFB0270w | SufE | cysteine desulfuration protein SufE | 2.8.1.7 |
|
| PF3D7_1242000 | PFL2020c | sulfhydryl oxidase | sulfhydryl oxidase, putative | 1.8.3.2 |
|
| PF3D7_0110200 | PFA0500w | Thiol oxidase; Erv1 | FAD-linked sulfhydryl oxidase ERV1, putative | 1.8.3.2 |
|
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFA0500w | FAD-linked sulfhydryl oxidase ERV1, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFB0270w
|
cysteine desulfuration protein SufE |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFB0320c | iron-sulfur assembly protein, putative |
| 2 | PFC1005c | iron-sulfur assembly protein, putative |
Total number of related proteins: 3
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFC0126c
|
CDGSH iron-sulfur domain-containing protein, putative |
| 2 | PFD0807c | CDGSH iron-sulfur domain-containing protein, putative |
| 3 | PF10_0222 | COX13 CDGSH iron-sulfur domain-containing protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFC0205c
|
1-cys-glutaredoxin-like protein-1 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFE0245c | mms19-like protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFE1135w
|
iron-sulfur cluster assembly protein SUFA |
Total number of related proteins: 3
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF07_0068
|
cysteine desulfurase |
| 2 |
MAL7P1.150
|
cysteine desulfurase ISCS |
| 3 |
MAL13P1.53
|
protein ISD11, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF07_0085 | ferrodoxin reductase-like protein |
| 2 | PF11_0407 | adrenodoxin reductase, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL8P1.78 | small heat shock protein HSP20, putative |
| 2 | PFI0985c | chaperone, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF08_0054
|
PfHsp70-1 |
| 2 |
PF11_0351
|
PfHsp70-3 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL8P1.31 | Fe-S cluster assembly protein DRE2, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFI0255c | mitochondrial carrier protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFI0525w | cytosolic Fe-S cluster assembly factor NBP35, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFI1050c
|
NifU-like scaffold protein |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFI1835c | NifU-like protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF11_0044
|
sulfur cluster assembly protein SufD |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF11_0258
|
GrpE protein homolog, mitochondrial, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF11_0296 | Fe-S cluster assembly factor hcf101, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFL0415w
|
acyl carrier protein, mitochondrial |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL0470w | cytosolic iron-sulfur protein assembly protein 1, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL0705c | adrenodoxin-type ferredoxin, putative |
| 2 | MAL13P1.95 | ferredoxin, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL2020c | sulfhydryl oxidase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL13P1.134 | DEAD box helicase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF13_0271
|
ABC transporter B family member 6, putative, ABCB6 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL13P1.307 | Fe-S assembly protein iscx, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF14_0133
|
ABC transporter I family member 1 FeS assembly ATPase SufC |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF14_0518 | iron-sulfur cluster assembly protein ISCU |