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Encoded proteins that could be constituents of P-bodies |
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P-bodies are sites of mRNA decay. In addition to proteins that are involved in mRNA degradation, P-body components include proteins with roles in mRNA surveillance, RNA interference and translational repression. mRNA decapping is an irreversible and therefore highly regulated process that requires the participation of several proteins. all proteins that function in the 5′→3′ mRNA-decay pathway have now been shown to localize to P bodies. Most P-body components are distributed diffusely throughout the cytoplasm as well as being localized in P-bodies. P-body components dynamically exchange with the cytoplasmic pool, which indicates that decay enzymes and co-activators are not confined to P-bodies. There is no evidence that P-bodies are present in Pf. Hence. this table is a suggestion that deserves some experimental verification |
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Hs or Sc ortholog |
PfID |
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Formal annotation |
Transcript |
EC# |
Effect of Depletion: or overexpression on P-body integrity |
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| 1595 |
XRN1/Kem1 |
PF3D7_1106300 |
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5'-3' exoribonuclease 1, putative |
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3.1.4.1 |
Depletion: increase in P-body size and numbers |
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| 1587 |
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PF3D7_0909400 |
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exoribonuclease, putative |
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3.1.13.1 |
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| 1593 |
DCP1/DCAP-1 |
PF3D7_1032100 |
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mRNA-decapping enzyme subunit 1, putative |
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Depletion: increase in P-body size and numbers |
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| 1601 |
DCP2/DCAP-2 |
PF3D7_1308900 |
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mRNA-decapping enzyme 2, putative |
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Depletion: increase in P-body size and numbers; overexpression: P-body loss |
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| 1596 |
Lsm1-7 |
PF3D7_1124400 |
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U6 snRNA-associated Sm-like protein LSm1, putative |
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| 1582 |
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PF3D7_0520300 |
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U6 snRNA-associated Sm-like protein LSm2, putative |
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| 1586 |
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PF3D7_0819900 |
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U6 snRNA-associated Sm-like protein LSm3, putative |
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Depletion: P-body loss in human but increase in yeast |
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| 1611 |
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PF3D7_1443300 |
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U6 snRNA-associated Sm-like protein LSm5, putative |
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| 1602 |
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PF3D7_1325000 |
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U6 snRNA-associated Sm-like protein LSm6, putative |
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| 1598 |
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PF3D7_1209200 |
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U6 snRNA-associated Sm-like protein LSm7, putative |
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| 1613 |
RAP55/Lsm14 |
PF3D7_1474900 |
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trailer hitch homolog, putative |
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Depletion: P-body loss; a marker of P-bodies |
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| 1577 |
RCK/p54/Me31B |
PF3D7_0320800 |
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ATP-dependent RNA helicase DDX6 |
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3.6.4.13 |
Depletion: P-body loss; overexpression: P-body loss but increase in size |
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| 1575 |
eIF4E |
PF3D7_0315100 |
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eukaryotic translation initiation factor 4E |
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ND |
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| 1590 |
UPF1 |
PF3D7_1005500 |
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regulator of nonsense transcripts 1, putative |
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Depletion: no effect |
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| 1589 |
UPF2 |
PF3D7_0925800 |
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regulator of nonsense transcripts 2, putative |
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Depletion: increase body size |
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| 1603 |
UPF3 |
PF3D7_1327700 |
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regulator of nonsense transcripts 3B, putative |
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Depletion: increase body size |
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| 1584 |
CAF-1 |
PF3D7_0811300 |
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CCR4-associated factor 1 |
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| 1580 |
CAF40 |
PF3D7_0507600 |
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protein caf40, putative |
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| 1609 |
NOT1 |
PF3D7_1417200 |
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CCR4-NOT transcription complex subunit not1, putative |
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| 1594 |
NOT1 |
PF3D7_1103800 |
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CCR4-NOT transcription complex subunit not1-g, putative |
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| 1597 |
NOT2 |
PF3D7_1128600 |
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CCR4-NOT transcription complex subunit 2, putative |
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| 1591 |
NOT5 |
PF3D7_1006100 |
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CCR4-NOT transcription complex subunit 5, putative |
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| 1581 |
CCR4 |
PF3D7_0519500 |
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ccr4 domain-containing protein 1, putative |
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Depletion: P-body loss |
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| 1571 |
CCR4 |
PF3D7_0107200 |
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ccr4 domain-containing protein 3, putative |
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Depletion: P-body loss |
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| 1576 |
CCR4 |
PF3D7_0319200 |
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ccr4 domain-containing protein 4, putative |
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Depletion: P-body loss |
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| 1573 |
FAST |
PF3D7_0217500 |
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Calcium-dependent protein kinases; CDPK1 |
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2.7.11.1 |
ND |
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| 1578 |
Rbp1 |
PF3D7_0414500 |
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RNA-binding protein, putative |
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ND |
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| 1572 |
Rbp4 |
PF3D7_0205500 |
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DNA-directed RNA polymerase II 16 kDa subunit, putative |
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2.7.7.6 |
ND |
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| 1607 |
Rbp4 |
PF3D7_1404000 |
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DNA-directed RNA polymerase II subunit RPB4, putative |
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2.7.7.6 |
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| 20874 |
Sbp1 |
PF3D7_0419600 |
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ran-specific GTPase-activating protein 1, putative |
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| 1610 |
Dcs2 |
PF3D7_1436900 |
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histidine triad protein, putative |
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3.6.1.29 |
ND |
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| 1606 |
APOBEC3G |
PF3D7_1349400 |
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cytidine and deoxycytidylate deaminase, putative |
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3.5.4.5 |
ND |
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Compounds involved in the stabilization of mRNA in cytoplasm |
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| 1577 |
Dhh1 |
PF3D7_0320800 |
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ATP-dependent RNA helicase DDX6 |
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3.6.4.13 |
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| 27625 |
Dhh1 |
PF3D7_0807100 |
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parasite specific helicase 3 |
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3.6.4.13 |
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| 1577 |
DDX6 |
PF3D7_0320800 |
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ATP-dependent RNA helicase DDX6 |
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3.6.4.13 |
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| 1613 |
CITH |
PF3D7_1474900 |
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trailer hitch homolog, putative |
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| 29795 |
Poly(A) binding protein |
PF3D7_1224300 |
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polyadenylate-binding protein 1, putative |
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| 1608 |
RNA binding protein Bruno, |
PF3D7_1409800 |
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CUGBP Elav-like family member 2 |
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| 1588 |
RNA-binding protein musashi |
PF3D7_0916700 |
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RNA-binding protein musashi, putative |
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| 1585 |
DNA/RNA-binding protein Alba, putative |
PF3D7_0814200 |
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DNA/RNA-binding protein Alba 1 |
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| 1605 |
DNA/RNA-binding protein Alba, putative |
PF3D7_1347500 |
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DNA/RNA-binding protein Alba 4 |
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| 1592 |
DNA/RNA-binding protein Alba, putative |
PF3D7_1006200 |
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DNA/RNA-binding protein Alba 3 |
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| 1604 |
DNA/RNA-binding protein Alba, putative |
PF3D7_1346300 |
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DNA/RNA-binding protein Alba 2 |
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| 1574 |
phosphoglycerate mutase |
PF3D7_0310300 |
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phosphoglycerate mutase, putative |
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5.4.2.11 |
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| 1612 |
Poly(A)-specific ribonuclease PARN |
PF3D7_1443500 |
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poly(A)-specific ribonuclease PARN, putative |
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3.1.13.4 |
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