Protein kinase coding genes
The list was prepared following Ward P, Equinet L, Packer J, Doerig C. 2004. Protein kinases of the human malaria parasite
Plasmodium falciparum: the kinome of a divergent eukaryote. BMC Genomics.5:79.
Additional annotations added by curator
PlasmoDB ID Annotation Literature Name Location Transcript EC# Essential
Cell-cycle-regulated protein kinases, Ser/Thr kinase
PFL0080c Serine/threonine-protein kinase, Pfnek-3 Pfnek-3 Apicoplast
Image left : 32px, top : 4px
2.7.11.1 not likely
PFF0260w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Serine/Threonine kinase, putative Pfnek-5 Spindle poles
Image left : 32px, top : 4px
2.7.11.1 yes
MAL7P1.100
Image left : 8px, top : 12px
NIMA related kinase 4 Pfnek-4 Spindle poles
Image left : 32px, top : 4px
2.7.11.1 no
PFE1290w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
NIMA related kinase 2 Pfnek-2 microtubules
Image left : 32px, top : 4px
2.7.11.1 not likely
PFL1370w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
NIMA-related protein kinase (Pfnek-1) Pfnek-1 cytoplasmic/ nuclear
Image left : 32px, top : 4px
2.7.11.1 yes
Cyclic-nucleotide- and calcium/phospholipid dependent kinases (AGC/Akt group)
PFL2250c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
rac-beta serine/threonine protein kinase, putative PfPKB
Image left : 32px, top : 4px
2.7.11.1 yes
PFI1685w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
cAMP-dependent protein kinase catalytic subunit PfPKA
Image left : 32px, top : 4px
2.7.11.11 likely
PF14_0346
Image left : 8px, top : 12px
Image left : 8px, top : 12px
cGMP-dependent PK 1, beta isozyme, putative; (CGKII) PfPKG
Image left : 32px, top : 4px
2.7.11.12 yes
MAL13P1.278
Image left : 8px, top : 12px
Serine/Threonine protein kinase PfARK3 perinuclear
Image left : 32px, top : 4px
2.7.11.1 yes
PFC0385c
Image left : 8px, top : 12px
Serine/threonine protein kinase, putative PfARK2
Image left : 32px, top : 4px
2.7.11.1 yes
PF11_0464 Serine/Threonine protein kinase ? Apicoplast
Image left : 32px, top : 4px
2.7.11.1 likely
PF11_0227 Serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 likely
Calmodulin-dependent kinases (CamK)
PF14_0227 Calcium-dependent protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 not likely
PFF0520w
Image left : 8px, top : 12px
Calcium-dependent protein kinase 2 PfCDPK2 Mitochondrion
Image left : 32px, top : 4px
2.7.11.1 likely
PF13_0211
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Calcium-dependent protein kinase CDPK
Image left : 32px, top : 4px
2.7.11.1 yes
PFC0420w
Image left : 8px, top : 12px
Calcium-dependent protein kinase, putative PfCDPK3
Image left : 32px, top : 4px
2.7.11.17 likely
PF07_0072
Image left : 8px, top : 12px
Calmodulin-domain protein kinase, putative PfCDPK4
Image left : 32px, top : 4px
2.7.11.1 no
PFB0815w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Calcium-dependent protein kinase 1 PfCDPK1
Image left : 32px, top : 4px
2.7.11.1 yes
PFC0945w
Image left : 8px, top : 12px
Protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17
PFB0665w Serine/Threonine protein kinase, putative -
Image left : 32px, top : 4px
2.7.11.1 no
PFC0485w Protein kinase, putative -
Image left : 32px, top : 4px
2.7.11.1 not likely
PF11_0242
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Calcium-dependent protein kinase
Image left : 32px, top : 4px
2.7.11.17 no
PF11_0060 Calcium/calmodulin-dependent protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 no
PF11_0239
Image left : 8px, top : 12px
Calcium/calmodulin-dependent protein kinase, putative
Image left : 32px, top : 4px
2.7.11.13 no
MAL7P1.18 Serine/threonine protein kinase, putative Mitochondrion 2.7.11.1 no
PF11_0377
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Casein kinase 1 PfCK1
Image left : 32px, top : 4px
2.7.11.1 yes
Cyclin-dependent-(CDK), mitogen-activated- (MAPK), glycogen-synthase-(GSK)
PF10_0141
Image left : 8px, top : 12px
Cyclin-dependent kinase 7, putative Pfmrk Nucleus
Image left : 32px, top : 4px
2.7.11.22 Yes
MAL13P1.279
Image left : 8px, top : 12px
Image left : 8px, top : 12px
protein kinase 5 PfPK5
Image left : 32px, top : 4px
2.7.11.22 yes
PFF0750w cdc2-like protein kinase, putative Pfcrk-5
Image left : 32px, top : 4px
2.7.11.22 not likely
PFD0865c
Image left : 8px, top : 12px
cdc2-related protein kinase 1 Pfcrk-1
Image left : 32px, top : 4px
2.7.11.22 likely
PFC0755c
Image left : 8px, top : 12px
cdc2-related protein kinase 4 Pfcrk-4
Image left : 32px, top : 4px
2.7.11.22 yes
PFD0740w
Image left : 8px, top : 12px
cdc-2 related kinase 3 Pfcrk-3
Image left : 32px, top : 4px
2.7.11.22 yes
MAL13P1.185
Image left : 8px, top : 12px
Image left : 8px, top : 12px
CDK-related protein kinase 6 PfPK6
Image left : 32px, top : 4px
2.7.11.22 likely
PFE0170c Protein kinase, putative
Image left : 32px, top : 4px
2.7.11.-
PF11_0079 Protein kinase, putative
Image left : 32px, top : 4px
2.7.10.2
PF14_0431
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Serine/Tthreonine kinase-1 PfLammer
Image left : 32px, top : 4px
2.7.11.1 yes
PFC0105w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Serine/Threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 yes
PF14_0408
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Serine/Threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 yes
MAL13P1.196 Serine/threonine-protein kinase, putative Apicoplast
Image left : 32px, top : 4px
2.7.11.1 no
PF11_0156
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Serine/Threonine protein kinase
Image left : 32px, top : 4px
2.7.11.1 likely
PF08_0044 Protein kinase PfPK1
Image left : 32px, top : 4px
2.7.11.1 no
MAL13P1.84
Image left : 8px, top : 12px
Protein kinase Mitochondrion
Image left : 32px, top : 4px
2.7.11.1 likely
PF11_0096
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Casein kinase II, alpha subunit, putative PfCK2
Image left : 32px, top : 4px
2.7.11.1 yes
PFC0525c
Image left : 8px, top : 12px
Glycogen synthase kinase, putative PfGSK3
Image left : 32px, top : 4px
2.7.11.26 yes
PF11_0147
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Mitogen-activated protein kinase 2 Pfmap-2
Image left : 32px, top : 4px
2.7.11.24 yes
PF14_0294
Image left : 8px, top : 12px
Mitogen-activated protein kinase 1 Pfmap-1
Image left : 32px, top : 4px
2.7.11.24 not likely
Tyrosine kinase like
PF13_0258
Image left : 8px, top : 12px
Image left : 8px, top : 12px
tyrosine kinase-like protein PfTKL3
Image left : 32px, top : 4px
2.7.10.2 yes
PFL1885c
Image left : 8px, top : 12px
Calcium/calmodulin-dependent protein kinase 2, putative PfPK2
Image left : 32px, top : 4px
2.7.11.1 likely
PFF1370w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Protein kinase PK4 PfPK4
Image left : 32px, top : 4px
2.7.11.1 yes
PFI1285w Protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 ?
PFI1275w Protein kinase, putative 2.7.11.1
MAL7P1.73 Calcium/calmodulin-dependent protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 not likely
PFL2280w
Image left : 8px, top : 12px
Serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 no
PF14_0516
Image left : 8px, top : 12px
snf1-related serine/threonine protein kinase kin PfKIN
Image left : 32px, top : 4px
2.7.11.1 yes
PFB0605w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Serine/Threonine protein kinase, putative PfPK7
Image left : 32px, top : 4px
2.7.11.1 not likely
PF14_0392 Serine/Threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 no
PF14_0423 eukaryotic initiation factor 2alpha kinase 1
Image left : 32px, top : 4px
2.7.11.1 not likely
PFA0380w Serine/Threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 not likely
PF13_0085
Image left : 8px, top : 12px
Image left : 8px, top : 12px
serine/threonine protein kinase PK9 PfPK9
Image left : 32px, top : 4px
2.7.11.1 yes
PFI1415w Serine/Threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 ?
MAL8P1.203
Image left : 8px, top : 12px
Image left : 8px, top : 12px
serine/threonine protein kinase, FIKK family
Image left : 32px, top : 4px
2.7.11.1
MAL7P1.91
Image left : 8px, top : 12px
Exported serine/threonine protein kinase PfFEST
Image left : 32px, top : 4px
2.7.11.1 likely
PFB0520w
Image left : 8px, top : 12px
Protein kinase, putative PfTKL1 Mitochondrion
Image left : 32px, top : 4px
2.7.11.1 yes
PFF1145c
Image left : 8px, top : 12px
tyrosine kinase-like protein PfTKL4
Image left : 32px, top : 4px
2.7.10.2 not likely
PFI1280c Protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 no
PFI1285w Protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17
PFB0150c
Image left : 8px, top : 12px
Protein kinase, putative PfPK8
Image left : 32px, top : 4px
2.7.11.1 no
PF11_0488
Image left : 8px, top : 12px
serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 yes
PF11_0220
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Protein kinase PfTKL2
Image left : 32px, top : 4px
2.7.10.2 no
PF14_0320 Protein kinase domain containing protein Apicoplast
Image left : 32px, top : 4px
2.7.11.1 ?
PF14_0264 Protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1
PF14_0476 Serine/Threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 not likely
FIKK family - apicomplexan protein kinases
PFD1175w
Image left : 8px, top : 12px
Serine/threonine protein kinase, FIKK family; Trophozoite antigen R45 R45 antigen
Image left : 32px, top : 4px
2.7.11.1
PF10_0380 Serine/threonine protein kinase, FIKK family; Trophozoite antigen R45 R45 Mitochondrion
Image left : 32px, top : 4px
2.7.11.1
PF10_0160
Image left : 8px, top : 12px
3.8 protein; Serine/threonine protein kinase, putative 3.8 protein
Image left : 32px, top : 4px
2.7.11.1
PFC0060c Serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1
PF11_0510 Serine/Threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1
PFA0130c Serine/Threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1
PF14_0733 Serine/Threonine protein kinase, FIKK family Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PF14_0733 Serine/Threonine protein kinase, FIKK family
Image left : 32px, top : 4px
2.7.11.1
PFI0120c
Image left : 8px, top : 12px
Serine/Threonine protein kinase, FIKK family Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PFD1165w
Image left : 8px, top : 12px
Serine/Threonine protein kinase, FIKK family
Image left : 32px, top : 4px
2.7.11.1
PFL0040c
Image left : 8px, top : 12px
Serine/Threonine protein kinase, FIKK family
Image left : 32px, top : 4px
2.7.11.1
PFI0110c Serine/Threonine protein kinase, FIKK family
Image left : 32px, top : 4px
2.7.11.1
PFI0125c Serine/Threonine protein kinase, FIKK family Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PFI0105c
Image left : 8px, top : 12px
Serine/Threonine protein kinase, FIKK family Apicoplast
Image left : 32px, top : 4px
2.7.11.1
MAL7P1.144
Image left : 8px, top : 12px
Serine/Threonine protein kinase, FIKK family
Image left : 32px, top : 4px
2.7.11.1
MAL7P1.175 Serine/Threonine protein kinase, FIKK family, pseudogene
Image left : 32px, top : 4px
2.7.11.1
PFI0095c Serine/Threonine protein kinase, FIKK family Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PFE0045c Serine/Threonine protein kinase, FIKK family
Image left : 32px, top : 4px
2.7.11.1
PF11_0239
Image left : 8px, top : 12px
Calcium/calmodulin-dependent protein kinase, putative
Image left : 32px, top : 4px
2.7.11.13
PFI0115c Serine/Threonine protein kinase, FIKK family Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PFI0100c
Image left : 8px, top : 12px
Serine/Threonine protein kinase, FIKK family 2.7.11.1
Atypical protein kinases
PF08_0098 ABC transporter, putative Mitochondrion
Image left : 32px, top : 4px
PF14_0143
Image left : 8px, top : 12px
Atypical protein kinase, ABC-1 family, putative
Image left : 32px, top : 4px
1.14.13.-
PFL1490w
Image left : 8px, top : 12px
Atypical protein kinase, RIO family, putative
Image left : 32px, top : 4px
2.7.11.1
PFD0975w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
RIO-like kinase
Image left : 32px, top : 4px
2.7.11.1
MAL7P1.132 Protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1
Protein kinase regulators
PF11_0048
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Casein kinase II beta chain, putative
Image left : 32px, top : 4px
2.7.11.1
PF13_0232
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Casein kinase II regulatory subunit, putative
Image left : 32px, top : 4px
2.7.11.1
PF14_0605
Image left : 8px, top : 12px
cyclin 1
Image left : 32px, top : 4px
PF13_0022 Cyclin 4
Image left : 32px, top : 4px
PFE0920c Cyclin 2 related protein, putative
Image left : 32px, top : 4px
PFL1110c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
cAMP-dependent protein kinase regulatory subunit, putative -
Image left : 32px, top : 4px
2.7.11.11
PFL1330c protein soc2, putative
Image left : 32px, top : 4px
PFL1335w conserved plasmodium protein, unknown functio
MAL8P1.145 Mitogen-activated protein kinase organizer 1, putative