Protein kinase coding genes
The list was prepared following Ward P, Equinet L, Packer J, Doerig C. 2004. Protein kinases of the human malaria parasite
Plasmodium falciparum: the kinome of a divergent eukaryote. BMC Genomics.5:79.
PlasmoDB ID Annotation Literature Name Location Transcript EC# Essential Role
Cell-cycle-regulated protein kinases, Ser/Thr kinase
PF3D7_1201600 NIMA related kinase 3 NEK3 Apicoplast
Image left : 32px, top : 4px
2.7.11.1 not likely Phosphorylation of MAP2
PF3D7_0605300
Image left : 8px, top : 12px
Image left : 8px, top : 12px
aurora-related kinase 1 serine/threonine protein kinase NEK5 Spindle poles
Image left : 32px, top : 4px
2.7.11.1 yes Localise at SPBs structures
PF3D7_0719200
Image left : 8px, top : 12px
NIMA related kinase 4 NEK4 Spindle poles
Image left : 32px, top : 4px
2.7.11.1 no Gametocytogenesis
PF3D7_0525900
Image left : 8px, top : 12px
Image left : 8px, top : 12px
NIMA related kinase 2 NEK2 microtubules
Image left : 32px, top : 4px
2.7.11.1 not likely
PF3D7_1228300
Image left : 8px, top : 12px
Image left : 8px, top : 12px
NIMA related kinase 1 NEK1 cytoplasmic/ nuclear
Image left : 32px, top : 4px
2.7.11.1 yes Phosphorylation of MAP2; replication
Cyclic-nucleotide- and calcium/phospholipid dependent kinases (AGC/Akt group)
PF3D7_1246900
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Image left : 8px, top : 12px
RAC-beta serine/threonine protein kinase PKB
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2.7.11.1 yes Phosphorylates GAP45; important for invasion
PF3D7_0934800
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Image left : 8px, top : 12px
cAMP-dependent protein kinase catalytic subunit PKAr
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2.7.11.11 likely Phosphorylation of PfAMA-1 cytoplasmic tail; important for invasion
PF3D7_1436600
Image left : 8px, top : 12px
Image left : 8px, top : 12px
cGMP-dependent protein kinase PKG
Image left : 32px, top : 4px
2.7.11.12 yes Phosphorylation of PfCDPK1 at apical pole of merozoite; Release of calcium stores & secretory organelles secretion
PF3D7_1356800
Image left : 8px, top : 12px
serine/threonine protein kinase, putative ARK3 perinuclear
Image left : 32px, top : 4px
2.7.11.1 yes Essential for erythrocytic stages, expressed during schizogony
PF3D7_0309200
Image left : 8px, top : 12px
serine/threonine protein kinase, putative ARK2
Image left : 32px, top : 4px
2.7.11.1 yes Essential for erythrocytic stages, expressed during schizogony
PF3D7_1145200 serine/threonine protein kinase, putative Apicoplast
Image left : 32px, top : 4px
2.7.11.1 likely
PF3D7_1121900 serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 likely
Calmodulin-dependent kinases (CamK)
PF3D7_1423600 calcium-dependent protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 not likely
PF3D7_0610600
Image left : 8px, top : 12px
calcium-dependent protein kinase 2 CDPK2 Mitochondrion
Image left : 32px, top : 4px
2.7.11.1 likely
PF3D7_1337800
Image left : 8px, top : 12px
Image left : 8px, top : 12px
calcium-dependent protein kinase 5, CDPK5 CDPK5
Image left : 32px, top : 4px
2.7.1.1 yes Egress of merozoite from RBCs
PF3D7_0310100
Image left : 8px, top : 12px
calcium-dependent protein kinase 3, CDPK3 CDPK3
Image left : 32px, top : 4px
2.7.11.17 likely
PF3D7_0717500
Image left : 8px, top : 12px
calcium-dependent protein kinase 4, CDPK4 CDPK4
Image left : 32px, top : 4px
2.7.11.1 no
PF3D7_0217500
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Calcium-dependent protein kinases; CDPK1 CDPK1
Image left : 32px, top : 4px
2.7.11.1 yes Egress, Micronemes secretion; important for invasion
PF3D7_0321400
Image left : 8px, top : 12px
protein kinase, putative STK
Image left : 32px, top : 4px
2.7.11.17 Phosphorylates GAP45 & MTIP
PF3D7_0214600 serine/threonine protein kinase, putative -
Image left : 32px, top : 4px
2.7.11.1 no
PF3D7_0311400 kinase-related protein pkrp -
Image left : 32px, top : 4px
not likely
PF3D7_1123100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
calcium-dependent protein kinase 7 CDPK7
Image left : 32px, top : 4px
2.7.11.17 no
PF3D7_1104900 calcium/calmodulin-dependent protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 no
PF3D7_1122800
Image left : 8px, top : 12px
calcium-dependent protein kinase 6 CDPK6
Image left : 32px, top : 4px
2.7.11.13 no
PF3D7_0704500 serine/threonine protein kinase, putative Mitochondrion 2.7.11.1 no
PF3D7_1136500
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Image left : 8px, top : 12px
casein kinase 1 CK1 micronemes
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2.7.11.1 yes mRNA splicing, protein trafficking, ribosomal, and host cell invasion.
Cyclin-dependent-(CDK), mitogen-activated- (MAPK), glycogen-synthase-(GSK)
PF3D7_1014400
Image left : 8px, top : 12px
MO15-related protein kinase MRK Nucleus
Image left : 32px, top : 4px
2.7.11.22 Yes
PF3D7_1356900
Image left : 8px, top : 12px
Image left : 8px, top : 12px
protein kinase 5 PK5
Image left : 32px, top : 4px
2.7.11.22 yes
PF3D7_0615500 cdc2-related protein kinase 5 CRK5
Image left : 32px, top : 4px
2.7.11.22 not likely Number of merozoites formed during schizogony
PF3D7_0417800
Image left : 8px, top : 12px
cdc2-related protein kinase 1 CRK1
Image left : 32px, top : 4px
2.7.11.22 yes
PF3D7_0317200
Image left : 8px, top : 12px
cdc2-related protein kinase 4 CRK4
Image left : 32px, top : 4px
2.7.11.22 yes
PF3D7_0415300
Image left : 8px, top : 12px
cdc2-related protein kinase 3 CRK3
Image left : 32px, top : 4px
2.7.11.22 yes
PF3D7_1337100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
protein kinase 6 PK6
Image left : 32px, top : 4px
2.7.11.22 yes replication
PF3D7_0503500 protein kinase, putative
Image left : 32px, top : 4px
2.7.11.-
PF3D7_1106800 protein kinase, putative
Image left : 32px, top : 4px
2.7.10.2
PF3D7_1445400
Image left : 8px, top : 12px
Image left : 8px, top : 12px
protein serine/threonine kinase-1 CLK1
Image left : 32px, top : 4px
2.7.11.1 yes
PF3D7_0302100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
serine/threonine protein kinase SRPK1
Image left : 32px, top : 4px
2.7.11.1 yes Male gamete formation (exflagellation)
PF3D7_1443000
Image left : 8px, top : 12px
Image left : 8px, top : 12px
serine/threonine protein kinase SRPK2
Image left : 32px, top : 4px
2.7.11.1 yes
PF3D7_1338900 serine/threonine protein kinase, putative Apicoplast
Image left : 32px, top : 4px
2.7.11.1 no
PF3D7_1114700
Image left : 8px, top : 12px
Image left : 8px, top : 12px
serine/threonine protein kinase, putative CLK3
Image left : 32px, top : 4px
2.7.11.1 likely
PF3D7_0821100 protein kinase 1 PK1
Image left : 32px, top : 4px
2.7.11.1 no
PF3D7_1316000
Image left : 8px, top : 12px
protein kinase, putative Mitochondrion
Image left : 32px, top : 4px
2.7.11.1 likely
PF3D7_1108400
Image left : 8px, top : 12px
Image left : 8px, top : 12px
casein kinase 2, alpha subunit CK2
Image left : 32px, top : 4px
2.7.11.1 yes Phosphorylation of PfRh4 cytoplasmic tail; important for invasion
PF3D7_0312400
Image left : 8px, top : 12px
glycogen synthase kinase 3 GSK3
Image left : 32px, top : 4px
2.7.11.26 yes
PF3D7_1113900
Image left : 8px, top : 12px
Image left : 8px, top : 12px
mitogen-activated protein kinase 2 MAPK2
Image left : 32px, top : 4px
2.7.11.24 yes
PF3D7_1431500
Image left : 8px, top : 12px
mitogen-activated protein kinase 1 MAPK1
Image left : 32px, top : 4px
2.7.11.24 not likely
Tyrosine kinase like
PF3D7_1349300
Image left : 8px, top : 12px
Image left : 8px, top : 12px
tyrosine kinase-like protein TKL3
Image left : 32px, top : 4px
2.7.10.2 yes
PF3D7_1238900
Image left : 8px, top : 12px
protein kinase 2 PK2
Image left : 32px, top : 4px
2.7.11.1 likely Important for invasion
PF3D7_0628200
Image left : 8px, top : 12px
Image left : 8px, top : 12px
eukaryotic translation initiation factor 2-alpha kinase PK4
Image left : 32px, top : 4px
2.7.11.1 yes Number of merozoites formed during schizogony
PF3D7_0926300 protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 ?
PF3D7_0926000 protein kinase, putative 2.7.11.1
PF3D7_0715300 calcium/calmodulin-dependent protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 not likely
PF3D7_1247500
Image left : 8px, top : 12px
serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 no
PF3D7_1454300
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snf1-related serine/threonine protein kinase kin KIN
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yes
PF3D7_0213400
Image left : 8px, top : 12px
Image left : 8px, top : 12px
protein kinase 7 PK7
Image left : 32px, top : 4px
2.7.11.1 not likely Number of merozoites formed during schizogony; Ookinete formation
PF3D7_1474700 protein kinase, putative
Image left : 32px, top : 4px
PF3D7_1441300 serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 no
PF3D7_1444500 eukaryotic initiation factor 2alpha kinase 1 eIK1
Image left : 32px, top : 4px
2.7.11.1 not likely Phosphorylation of eIF2-translatin inhibition
PF3D7_1331000 protein kinase, putative
Image left : 32px, top : 4px
PF3D7_0107600 serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 not likely
PF3D7_1315100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
serine/threonine protein kinase PK9 PK9
Image left : 32px, top : 4px
2.7.11.1 yes
PF3D7_0928800 serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 ?
PF3D7_0718100
Image left : 8px, top : 12px
exported serine/threonine protein kinase EST
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2.7.11.1 likely
PF3D7_0211700
Image left : 8px, top : 12px
tyrosine kinase-like protein, putative TKL1 Mitochondrion
Image left : 32px, top : 4px
2.7.11.1 yes
PF3D7_0623800
Image left : 8px, top : 12px
tyrosine kinase-like protein, putative TKL4
Image left : 32px, top : 4px
2.7.10.2 not likely
PF3D7_0926100 protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 no
PF3D7_0926300 protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17
PF3D7_0203100
Image left : 8px, top : 12px
protein kinase, putative PfPK8
Image left : 32px, top : 4px
2.7.11.1 no
PF3D7_1148000
Image left : 8px, top : 12px
serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1 yes
PF3D7_1121300
Image left : 8px, top : 12px
Image left : 8px, top : 12px
tyrosine kinase-like protein TKL2
Image left : 32px, top : 4px
2.7.10.2 no
PF3D7_1433900 protein kinase, putative Apicoplast
Image left : 32px, top : 4px
2.7.11.1 ?
PF3D7_1428500 protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1
PF3D7_1450000 serine/threonine protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 not likely
PF3D7_0926300 protein kinase, putative
Image left : 32px, top : 4px
2.7.11.17 not likely
FIKK family - apicomplexan protein kinases
PF3D7_0424700
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serine/threonine protein kinase, FIKK family FIKK4.2
Image left : 32px, top : 4px
2.7.11.1
PF3D7_1039000 serine/threonine protein kinase, FIKK family FIKK10.2 Mitochondrion
Image left : 32px, top : 4px
2.7.11.1
PF3D7_1016400
Image left : 8px, top : 12px
serine/threonine protein kinase, FIKK family FIKK10.1
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0301200 serine/threonine protein kinase, FIKK family FIKK3
Image left : 32px, top : 4px
2.7.11.1
PF3D7_1149300 serine/threonine protein kinase, FIKK family FIKK11
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0102600 serine/threonine protein kinase, FIKK family FIKK1
Image left : 32px, top : 4px
2.7.11.1
PF3D7_1476400 serine/threonine protein kinase, FIKK family, pseudogene FIKK14 Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0902500
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serine/threonine protein kinase, FIKK family FIKK9.6 Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0424500
Image left : 8px, top : 12px
serine/threonine protein kinase, FIKK family FIKK4.1 Maurer's clefts
Image left : 32px, top : 4px
2.7.11.1
PF3D7_1200800
Image left : 8px, top : 12px
serine/threonine protein kinase, FIKK family FIKK12 Maurer's clefts
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0902300 serine/threonine protein kinase, FIKK family FIKK9.4
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0902600 serine/threonine protein kinase, FIKK family FIKK9.7 Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0902200
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serine/threonine protein kinase, FIKK family FIKK9.3 Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0726200
Image left : 8px, top : 12px
serine/threonine protein kinase, FIKK family FIKK7.1
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0731400 serine/threonine protein kinase, FIKK family, pseudogene FIKK7.2
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0902000 serine/threonine protein kinase, FIKK family FIKK9.1 Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0500900 serine/threonine protein kinase, FIKK family FIKK5
Image left : 32px, top : 4px
2.7.11.1
PF3D7_1122800
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calcium-dependent protein kinase 6 CDPK6
Image left : 32px, top : 4px
2.7.11.13
PF3D7_0902400 serine/threonine protein kinase, FIKK family FIKK9.5 Apicoplast
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0902100
Image left : 8px, top : 12px
serine/threonine protein kinase, FIKK family FIKK9.2 Maurer's clefts 2.7.11.1
PF3D7_1371700 serine/threonine protein kinase, FIKK family
Atypical protein kinases
PF3D7_0810200 ABC1 family, putative, ABCK1 ABCK1 Mitochondrion
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PF3D7_1414500
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atypical protein kinase, ABC-1 family, putative ABCk2
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1.14.13.-
PF3D7_1230900
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serine/threonine protein kinase RIO1, putative RIO1
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0420100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
serine/threonine protein kinase RIO2 RIO2
Image left : 32px, top : 4px
2.7.11.1
PF3D7_0724600 protein kinase, putative
Image left : 32px, top : 4px
2.7.11.1
Protein kinase regulators
PF3D7_1103700
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Image left : 8px, top : 12px
casein kinase II beta chain
CK2beta1
Image left : 32px, top : 4px
2.7.11.1
PF3D7_1342400
Image left : 8px, top : 12px
Image left : 8px, top : 12px
casein kinase II beta chain
CK2beta2
Image left : 32px, top : 4px
2.7.11.1
PF3D7_1463700
Image left : 8px, top : 12px
cyclin 1 CYC1
Image left : 32px, top : 4px
PF3D7_1304700 cyclin CYC4
Image left : 32px, top : 4px
PF3D7_0518400 cyclin CYC3
Image left : 32px, top : 4px
PF3D7_1223100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
cAMP-dependent protein kinase regulatory subunit PKAr
Image left : 32px, top : 4px
2.7.11.11
PF3D7_1227500 protein soc2, putative SOC2
Image left : 32px, top : 4px
PF3D7_0803300 mitogen-activated protein kinase organizer 1, putative MORG1
PF3D7_0817500
Image left : 8px, top : 12px
histidine triad nucleotide-binding protein 1 HINT1
PF3D7_0511700
Image left : 8px, top : 12px
EKC/KEOPS complex subunit CGI121 CGI121
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Online articles related to Protein kinase coding genes retrieved from PubMed