Regulators of alternative splicing
Fu XD, Ares M Jr. Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet. 2014 15(10):689-701. PMID: 25112293
PfID Annotation Human orthologs and their finction EC# Transcript
Splicing regulators
PF3D7_1359400
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CUGBP Elav-like family member 1 CUGBP1 Binds to intronic regions and antagonizes MBNL1 UGUU
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PF3D7_1019300 zinc finger MBNL1 Bind to intronic regions with positional effects YGCY 83
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PF3D7_1134600 zinc finger MBNL2 Bind to intronic regions with positional effects YGCY 83
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PF3D7_1415300 RNA-binding protein Nova-1 NOVA Binds to both exons and introns with positional effects YCAY
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PF3D7_0606500 polypyrimidine tract-binding protein, PTB and nPTB Bind to intronic regions to mediate splicing repression CU‑rich 68
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PF3D7_1107100 nucleic acid binding protein, putative RBFOX1 and RBFOX2 Bind to intronic regions with positional effects GCAUG 82
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PF3D7_1224300
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polyadenylate-binding protein TIA‑1 Bind to intronic regions with positional effects U‑rich
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PF3D7_1321700 splicing factor 1 TIAL1 Bind to intronic regions with positional effects U‑rich
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PF3D7_0623600 transcription or splicing factor-like protein, putative QKI Binds to intronic regions with positional effects UAA
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PF3D7_1024200 RNA-binding protein ESRPs ' Bind to intronic regions with positional effects GU‑rich
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PF3D7_1224300
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polyadenylate-binding protein RBM4 Binds to intronic regions with positional effects CGG or CTAACG 40
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PF3D7_1353400 Ran-binding protein, putative RBM5 Binds to intronic regions with positional effects UCAUC or UGUAA
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PF3D7_1353400 Ran-binding protein, putative RBM6 Bind to intronic regions with positional effects CUCUGAA
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PF3D7_1353400 Ran-binding protein, putative RBM10 Bind to intronic regions with positional effects CUCUGAA
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PF3D7_1359400
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CUGBP Elav-like family member 1 ELAV1 Binds to intronic and 3ʹ untranslated regions U-rich or AU‑rich
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PF3D7_1461600 splicing factor 3B subunit 2 SFA3B
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PF3D7_0924700 splicing factor 3A subunit 3 SF3A
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3ʹsplice site factors
PF3D7_1468800 splicing factor U2AF large subunit, U2AF65 Defines functional 3ʹ splice sites in most introns Pyrimidine‑rich
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PF3D7_1119300 splicing factor U2AF small subunit U2AF35
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PF3D7_0623600 transcription or splicing factor-like protein, putative SF1 Binds to branchpoint sequences and other intronic regions ACUNAC
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SR proteins
PF3D7_0517300
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serine/arginine-rich splicing factor 1 SRSF1 Enhances splicing on ESEs in a context-sensitive manner GGAGGA
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PF3D7_1126800 RNA-binding protein SRSF2 Enhances splicing on ESEs in a context-sensitive manner SSNG
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PF3D7_0517300
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serine/arginine-rich splicing factor 1 SRSF3 Has a slight preference for exonic over intronic regions Pyrimidine‑rich
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PF3D7_1022400
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serine/arginine-rich splicing factor 4 SRSF4 Has a slight preference for exonic over Intronic regions Purine‑rich
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PF3D7_0503300
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serine/arginine-rich splicing factor 12 SR
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PF3D7_1407000 LCCL domain-containing protein SR1
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PF3D7_1454300
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serine/threonine protein kinase KIN SR2
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hnRNPs
PF3D7_0414500 RNA-binding protein hnRNP A1 Binds to intronic regions to repress splicing on ESSs GNNAGN
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PF3D7_0414500 RNA-binding protein hnRNP A2 and hnRNP B1 ' Bind to intronic regions to repress splicing on ESSs GGUAGU
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PF3D7_1004400 RNA-binding protein hnRNP C Binds to intronic regions and competes with U2AF65 at Alu sequences Pyrimidine‑rich
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PF3D7_1126900 small nuclear ribonucleoprotein F, hnRNP F Binds to intronic regions to enhance or repress splicing GU‑rich
PF3D7_1024200 RNA-binding protein hnRNP H1 Binds to intronic regions to enhance or repress splicing G‑run
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PF3D7_0606500 polypyrimidine tract-binding protein, hnRNP L Binds to intronic regions to enhance or repress splicing CA‑rich
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PF3D7_1006800 single-strand telomeric DNA-binding protein GBP2 hnRNP M Binds to intronic regions to enhance or repress splicing GGUGG
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PF3D7_0521700 ATP-dependent RNA helicase DDX1 hnRNP U Binds to intronic regions to regulate U2 snRNP maturation GU‑rich 3.6.4.13
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PF3D7_0606500 polypyrimidine tract-binding protein, hnRNP L Binds to intronic regions to enhance or repress splicing CA‑rich
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PF3D7_1006800 single-strand telomeric DNA-binding protein GBP2 hnRNP M Binds to intronic regions to enhance or repress splicing GGUGG
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PF3D7_0521700 ATP-dependent RNA helicase DDX1 hnRNP U Binds to intronic regions to regulate U2 snRNP maturation GU‑rich 3.6.4.13
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snRNPs
PF3D7_0822300 small nuclear ribonucleoprotein G
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PF3D7_0218500
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small nuclear ribonucleoprotein Sm D2
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PF3D7_1369700 U2 small nuclear ribonucleoprotein A', putative
PF3D7_0935000 U2 small nuclear ribonucleoprotein B'', putative
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PF3D7_0812700 U1 small nuclear ribonucleoprotein c, putative
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PF3D7_1367100 U1 small nuclear ribonucleoprotein 70 kda homolog, putative
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PF3D7_1306900 U1 small nuclear ribonucleoprotein A, putative
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Online articles related to Regulators of alternative splicing retrieved from PubMed