Differentially expressed genes in different stages treated with cAMP
Lima WR, Tessarin-Almeida G, Rozanski A, Parreira KS, Moraes MS, Martins DC, Hashimoto RF, Galante PA, Garcia CR. Signaling transcript profile of the asexual intraerythrocytic development cycle of Plasmodium falciparum induced by melatonin and cAMP. Genes Cancer. 2016 7(9-10):323-339. PMID: 28050233
RING
New PfID Old PfID Annotation Fold change EC# Transcript
33599 PF3D7_0107500 PFA0375c
Niemann-Pick type c1-related protein 7
25833 PF3D7_1357900 MAL13P1.284 pyrroline-5-carboxylate reductase, putative 7 1.5.1.2
24138 PF3D7_0817300 PF08_0060 conserved Plasmodium protein, unknown function, asparagine-rich antigen 6
24255 PF3D7_1465900 PF14_0627 40S ribosomal protein S3 5
24109 PF3D7_0611000 PFF0540c SNARE associated Golgi protein, putative 5
24163 PF3D7_1009200 PF10_0089 ribonuclease, putative 5
24198 PF3D7_1220900 PFL1005c
heterochromatin protein 1 5
24063 PF3D7_0212500 PFB0560w conserved Plasmodium protein, unknown function 5
24094 PF3D7_0424600 PFD1170c
plasmodium exported protein (phistb) 5
24192 PF3D7_1211800 PFL0585w polyubiquitin 5
24189 PF3D7_1201600 PFL0080c NIMA related kinase 3 5 2.7.11.1
24149 PF3D7_0913200 PFI0645w elongation factor 1-beta 4
24210 PF3D7_1255100 PFL2660w rifin 4
24106 PF3D7_0600200 PFF0010w erythrocyte membrane protein 1, PfEMP1 4
24120 PF3D7_0700700 MAL8P1.214 stevor, pseudogene 4
24179 PF3D7_1115900 PF11_0167
palmitoyltransferase DHHC9 3 2.3.1.-
24155 PF3D7_0922400 PFI1100w
para-aminobenzoic acid synthetase 3 2.6.1.85
24175 PF3D7_1040100 PF10_0394 rifin 3
24251 PF3D7_1446400 PF14_0441
pyruvate dehydrogenase E1 component subunit beta 3 1.2.4.1
24075 PF3D7_0317600 PFC0775w 40S ribosomal protein S11, putative 3
24093 PF3D7_0422400 PFD1055w 40S ribosomal protein S19 3
24118 PF3D7_0629300 PFF1420w phospholipase, putative phosphatidylcholine-sterol acyltransferase, putative 2 2.3.1.43
24066 PF3D7_0217800 PFB0830w 40S ribosomal protein S26 2
24212 PF3D7_1303500 PF13_0019
sodium/hydrogen exchanger, Na+, H+ antiporter NHE 2
24136 PF3D7_0809600 MAL8P1.113 peptidase family C50, putative separase, putative 2 3.4.22.49
+ 12 upregulated conserved Plasmodium proteins of unknown function
24168 PF3D7_1023900 PF10_0232
SNF2 helicase, putative chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.5 3.6.4.12
24057 PF3D7_0114000 PFA0675w exported protein family 1; MEC domain-containing protein 0.5
24204 PF3D7_1238900 PFL1885c
protein kinase 2 0.5 2.7.11.1
24213 PF3D7_1308200 PF13_0044
carbamoyl phosphate synthetase 0.5 6.3.5.5
24058 PF3D7_0115500 PFA0755w erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.5
24235 PF3D7_1371800 MAL13P1.110 Plasmodium exported protein, unknown function 0.5
24185 PF3D7_1141800 PF11_0429
EELM2 domain-containing protein, putative 0.25
24218 PF3D7_1331400 PF13_0168 CPW-WPC family protein 0.25
34017 PF3D7_1428700 PF14_0266 heme/steroid binding domain containing protein, putative 0.25
24140 PF3D7_0822000 PF08_0038
mitochondrial ribosomal protein L4 precursor, putative 0.25
24224 PF3D7_1343000 MAL13P1.214
phosphoethanolamine N-methyltransferase 0.25 2.1.1.103
24081 PF3D7_0403800 PFD0185c alpha/beta hydrolase, putative 0.25
24159 PF3D7_0932100 PFI1560c protein MAM3, putative 0.25
24182 PF3D7_1130000 PF11_0311 phosphoacetylglucosamine mutase, putative 0.25 5.4.2.3
24145 PF3D7_0900100 PFI0005w erythrocyte membrane protein 1, PfEMP1 0.25
24142 PF3D7_0828300 PF08_0010 conserved Plasmodium protein, unknown function 0.25
24143 PF3D7_0828500 PF08_0009 translation initiation factor eIF-2B subunit alpha, putative 0.25
24095 PF3D7_0424700 PFD1175w
serine/threonine protein kinase, FIKK family 0.25 2.7.11.1
24090 PF3D7_0415300 PFD0740w
cdc2-related protein kinase 3 0.25 2.7.11.22
24200 PF3D7_1235700 PFL1725w
ATP synthase subunit beta, mitochondrial 0.25 3.6.3.14
24162 PF3D7_1008200 PF10_0080 flap endonuclease, putative 0.25 4.2.99.18
24211 PF3D7_1302800 PF13_0014 40S ribosomal protein S7, putative 0.25
24051 PF3D7_0103400 PFA0170c zinc-carboxypeptidase, putative 0.13 3.4.17.10
24141 PF3D7_0826100 MAL8P1.23 HECT-like E3 ubiquitin ligase, putative 0.13 6.3.2.19
24119 PF3D7_0632500 PFF1580c erythrocyte membrane protein 1, PfEMP1 0.13
24091 PF3D7_0420000 PFD0970c zinc finger protein, putative 0.13
24074 PF3D7_0316800 PFC0735w 40S ribosomal protein S15A, putative 0.13
24114 PF3D7_0617600 PFF0850c
PIR protein stevor 0.13
24188 PF3D7_1200300 PFL0015c PIR protein rifin 0.13
+ 11 downregulated conserved Plasmodium proteins of unknown function
Trophozoite
New PfID Old PfID Fold change EC#
24181 PF3D7_1116600 PF11_0173 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3, putative 7 2.4.99.18
24127 PF3D7_0722400 MAL7P1.122 OBG-like ATPase 1, putative 6.1
24177 PF3D7_1108500 PF11_0097 succinate--CoA ligase [ADP-forming] subunit alpha, putative 5.8 6.2.1.4
24202 PF3D7_1237600 PFL1820w periodic tryptophan protein 1, putative 5.8
24122 PF3D7_0707800 MAL7P1.23 RAP protein, putative 5.3
24203 PF3D7_1238800 PFL1880w
acyl-CoA synthetase 5.3 6.2.1.3
24205 PF3D7_1239000 PFL1890c HD superfamily phosphohydrolase protein 5.3 3.1.4.17
25572 PF3D7_1209300 PFL0465c
telomere repeat-binding zinc finger protein, putative 5.3
24123 PF3D7_0708500 PF07_0030 heat shock protein 86 family protein 4.9
24150 PF3D7_0913500 PFI0660c
apicoplast-minus ipp-rescued 4 4.9
24103 PF3D7_0518500 PFE0925c
ATP-dependent RNA helicase DDX23, putative 4.4 3.6.4.13
29846 PF3D7_0501700 PFE0085c
anaphase-promoting complex subunit 3, putative 4.4
24237 PF3D7_1406400 PF14_0061
pentatricopeptide repeat domain-containing protein 1 4.4
24223 PF3D7_1342600 PF13_0233
myosin A 3.9
24128 PF3D7_0724300 MAL7P1.130 3-demethylubiquinone-9 3-methyltransferase, putative 3.4 2.1.1.64
24221 PF3D7_1338100 MAL13P1.190 26S proteasome regulatory subunit RPN3, putative 3.3
24052 PF3D7_0103800 PFA0190c actin-related protein arp1, putative 3.1
24117 PF3D7_0627800 PFF1350c
acetyl-CoA synthetase 2.9 6.2.1.1
24082 PF3D7_0404700 PFD0230c
dipeptidyl aminopeptidase 3 2.7 3.4.14.4
24233 PF3D7_1368200 MAL13P1.344
ABC transporter E family member 1, putative 2.7
24137 PF3D7_0810500 MAL8P1.108 protein phosphatase PPM7, putative 2.6 3.1.3.16
38984 PF3D7_1428200 PF14_0260 major facilitator superfamily domain-containing protein, putative, MFS5 2.6
24121 PF3D7_0703500 MAL7P1.12
erythrocyte membrane-associated antigen 2.5
24193 PF3D7_1211900 PFL0590c
non-SERCA-type Ca2+ -transporting P-ATPase, ATP4 2.5 3.6.3.2
24239 PF3D7_1411900 PF14_0117
p1/s1 nuclease, putative 2.4 3.1.30.1
24169 PF3D7_1029600 PF10_0289
adenosine deaminase 2.4 3.5.4.4
24187 PF3D7_1200200 PFL0010c PIR protein rifin 2.3
24073 PF3D7_0316600 PFC0725c
formate-nitrite transporter, FNT 2.3
24204 PF3D7_1238900 PFL1885c
protein kinase 2 2.2 2.7.11.1
24246 PF3D7_1430100 PF14_0280
serine/threonine protein phosphatase 2A activator 2.2
25545 PF3D7_1216200 PFL0780w glycerol-3-phosphate dehydrogenase [NAD+], putative 2.1 1.1.1.8
24152 PF3D7_0917900 PFI0875w
PfHsp70-2 2.1
24061 PF3D7_0207700 PFB0345c
serine repeat antigen 4 2 3.4.22.-
+ 16 upregulated conserved Plasmodium proteins of unknown function
24219 PF3D7_1334700 PF13_0194
MSP7-like protein 0.5
24146 PF3D7_0905400 PFI0265c
high molecular weight rhoptry protein 3 0.5
24157 PF3D7_0929400 PFI1445w
high molecular weight rhoptry protein 2 0.5
24212 PF3D7_1303500 PF13_0019
sodium/hydrogen exchanger, Na+, H+ antiporter NHE 0.4
25585 PF3D7_0204900 PFB0220w 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial, putative 0.4 2.1.1.201
24229 PF3D7_1362400 MAL13P1.310
calpain 0.4 3.4.22.-
24072 PF3D7_0313100 PFC0550w ubiquitin-protein ligase, putative 0.4
24225 PF3D7_1343600 MAL13P1.218 UDP-N-acetylglucosamine pyrophosphorylase, putative 0.4 2.7.7.23
24125 PF3D7_0717700 PF07_0073
serine--tRNA ligase, putative 0.3 6.1.1.11
24089 PF3D7_0411900 PFD0590c DNA polymerase alpha 0.3 2.7.7.7
29730 PF3D7_1466400 PF14_0633
AP2 domain transcription factor AP2-SP/EXP 0.3
24222 PF3D7_1339900 PF13_0218
ABC transporter B family member 5, putative, ABCB5 0.3 3.6.3.44
24069 PF3D7_0303900 PFC0176c phosphatidylethanolamine-binding protein, putative 0.3
24098 PF3D7_0506900 PFE0340c
rhomboid protease ROM4 0.3 3.4.21.105
24097 PF3D7_0505300 PFE0260w UDP-n-acetylglucosamine transporter, putative 0.3
24253 PF3D7_1447000 PF14_0448 40S ribosomal protein S5 0.3
24135 PF3D7_0809500 MAL8P1.114 histone acetyltransferase subunit NuA4, putative 0.2 2.3.1.48
33935 PF3D7_1249900 PFL2395c ribosomal RNA small subunit methyltransferase a2, putative 0.2
24078 PF3D7_0400200 PFD0010w erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.2
24080 PF3D7_0402400 PFD0115c
Plasmodium exported protein, unknown function gametocyte exported protein 18 0.2
24099 PF3D7_0509000 pfe0445c alpha-soluble nsf attachment protein, putative 0.2
24066 PF3D7_0217800 PFB0830w 40S ribosomal protein S26 0.2
24166 PF3D7_1017200 PF10_0167
enoyl-CoA hydratase-related protein, putative 0.2 4.2.1.17
24071 PF3D7_0310700 PFC0445w trafficking protein particle complex subunit 4, putative 0.2
24065 PF3D7_0216000 PFB0730w DEAD/DEAH box helicase, putative 0.2 3.6.4.13
24180 PF3D7_1116000 PF11_0168
rhoptry neck protein 4 0.1
24190 PF3D7_1205800 PFL0290w high mobility group protein B3, putative 0.1
24220 PF3D7_1334800 MAL13P1.174
MSP7-like protein 0.1
24199 PF3D7_1229300 PFL1415w
phil1-interacting candidate pic1 0.1
24165 PF3D7_1011000 PF10_0107
inner membrane complex sub-compartment protein 1 0.1
+ 12 downregulated conserved Plasmodium proteins of unknown function
Schizont
New PfID Old PfID Fold change EC#
24158 PF3D7_0930600 PFI1490c peptidyl-prolyl cis-trans isomerase 9.6 5.2.1.8
33972 PF3D7_1316600 MAL13P1.86
CTP:phosphocholine cytidylyltransferase 7.8 2.7.7.15
24104 PF3D7_0522500 PFE1125w 50S ribosomal protein L17, apicoplast, putative 6.4
24184 PF3D7_1133200 PF11_0342 conserved Plasmodium protein, unknown function 6.4
24056 PF3D7_0113600 PFA0650w surface-associated interspersed protein 1.2 (SURFIN 1.2), pseudogene 5.7
24056 PF3D7_0113600 PFA0650w surface-associated interspersed protein 1.2 (SURFIN 1.2), pseudogene 5.7
24154 PF3D7_0920200 PFI0990c CS domain protein, putative 5.7
24264 PF3D7_1131500 PF11_0325 conserved Plasmodium protein, unknown function 5.7
24201 PF3D7_1236700 PFL1775c S-adenosyl-methyltransferase, putative 5.7 2.1.1.12
24115 PF3D7_0624100 PFF1160w conserved Plasmodium protein, unknown function 5.6
24147 PF3D7_0908600 PFI0415c ribosomal RNA methyltransferase, putative 5.4 2.1.1.56
24254 PF3D7_1458500 PF14_0558
spindle assembly abnormal protein 4, putative 5.3
24249 PF3D7_1439900 PF14_0378
triosephosphate isomerase 5.1 5.3.1.1
24085 PF3D7_0407100 PFD0350w methyltransferase, putative 4.9 2.1.1.201
24227 PF3D7_1354400 MAL13P1.271 V-type proton ATPase 21 kDa proteolipid subunit, putative 4.6 3.6.3.14
24087 PF3D7_0409200 PFD0455w protein SOF1, putative 4.5
24111 PF3D7_0614800 PFF0715c endonuclease III homologue, putative 4.5 4.2.99.18
24174 PF3D7_1039000 PF10_0380
serine/threonine protein kinase, FIKK family 4.3 2.7.11.1
24088 PF3D7_0409600 PFD0475c replication protein A1, large subunit 4.3
24230 PF3D7_1366400 PF13_0348
rhoptry protein RHOP148 4.1
24101 PF3D7_0514600 PFE0730c ribose-5-phosphate isomerase 4.1 5.3.1.6
24102 PF3D7_0517000 PFE0850c 60S ribosomal protein L12, putative 4
24055 PF3D7_0113200 PFA0630c
Plasmodium exported protein, unknown function 4
24076 PF3D7_0317800 PFC0785c 26s proteasome non-atpase regulatory subunit 9, putative 4
24206 PF3D7_1240600 PFL1960w
erythrocyte membrane protein 1, PfEMP1 4
24176 PF3D7_1106200 PF11_0073 conserved Plasmodium protein, unknown function 3.7
24134 PF3D7_0803500 MAL8P1.144 AAA family ATPase, putative 3.7
24240 PF3D7_1414300 PF14_0141 60S ribosomal protein L10, putative 3.5
24156 PF3D7_0926300 PFI1285w protein kinase, putative 3.4 2.7.11.17
24151 PF3D7_0917600 PFI0860c
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative 3.1 3.6.4.13
25520 PF3D7_1033600 PF10_0327 pre-mRNA-splicing factor cef1, putative 3
24248 PF3D7_1437800 PF14_0358 41-2 protein antigen precursor trafficking protein particle complex subunit 5, putative 2.9
24079 PF3D7_0401800 PFD0080c
Plasmodium exported protein (PHISTb), unknown function 2.9
24241 PF3D7_1420000 PF14_0194 splicing factor 3B subunit 4, putative 2.8
24216 PF3D7_1323000 PF13_0128
beta-hydroxyacyl-ACP dehydratase 2.6 4.2.1.59
24160 PF3D7_0935800 PFI1730w
cytoadherence linked asexual protein 9 2.6
24178 PF3D7_1113100 PF11_0139
protein tyrosine phosphatase 2.6 3.1.3.48
24105 PF3D7_0525800 PFE1285w
inner membrane complex protein 1g, putative 2.4
24126 PF3D7_0718400 MAL7P1.93 ribosomal protein S8, mitochondrial, putative 2.4
29864 PF3D7_0602500 PFF0120w geranylgeranyl transferase type-2 subunit beta, putative 2.1 2.5.1.59
24231 PF3D7_1366500 PF13_0349
nucleoside diphosphate kinase 2.1 2.7.4.6
24068 PF3D7_0301100 PFC0055w Plasmodium exported protein (hyp13), unknown function 2.1
24062 PF3D7_0211800 PFB0525w asparagine--tRNA ligase 2.1 6.1.1.22
24167 PF3D7_1021800 PF10_0212a
schizont egress antigen-1 2.1
24084 PF3D7_0406200 PFD0310w
parasitophorous vacuole membrane protein s16; sexual stage-specific protein s16 2
+ 20 upregulated conserved Plasmodium proteins of unknown function
24153 PF3D7_0918900 PFI0925w
gamma-glutamylcysteine synthetase 0.5 6.3.2.2
24171 PF3D7_1035100 PF10_0342 probable protein, unknown function 0.5
24194 PF3D7_1215200 PFL0735w peptidyl-prolyl cis-trans isomerase 0.5 5.2.1.8
24092 PF3D7_0420300 PFD0985w AP2 domain transcription factor 0.5
24124 PF3D7_0709100 PF07_0035 Cg1 protein 0.5
24117 PF3D7_0627800 PFF1350c
acetyl-CoA synthetase 0.5 6.2.1.1
24067 PF3D7_0218400 PFB0860c ATPdependent RNA helicase ddx47, putative 0.5 3.6.4.13
24110 PF3D7_0612800 PFF0620c 6-cysteine protein p12p 0.5
24197 PF3D7_1217600 PFL0850w anaphase-promoting complex subunit 10, putative 0.5
24116 PF3D7_0624700 PFF1190c
N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.5 3.5.1.89
24129 PF3D7_0727800 PF07_0115
cation transporting ATPase, putative 0.5 3.6.3.12
24257 PF3D7_1468800 PF14_0656 splicing factor U2AF large subunit, putative 0.5
24226 PF3D7_1344800 MAL13P1.221
aspartate carbamoyltransferase 0.5 2.1.3.2
24164 PF3D7_1010300 PF10_0100
succinate dehydrogenase subunit 4, putative 0.4 1.3.5.1
24252 PF3D7_1446900 PF14_0447 glutaminyl-peptide cyclotransferase, putative 0.4 2.3.2.5
24144 PF3D7_0831600 MAL7P1.229
cytoadherence linked asexual protein 8 0.4
24258 PF3D7_1476600 PF14_0736 Plasmodium exported protein, unknown function 0.4
24131 PF3D7_0800400 PF3D7_0800400
rifin PIR protein 0.4
24214 PF3D7_1311500 PF13_0063
26S protease regulatory subunit 7, putative; 26S proteasome AAA-ATPase subunit RPT1, putative 0.4 3.6.4.8
24132 PF3D7_0802300 PF08_0130 periodic tryptophan protein 2, putative 0.4
24064 PF3D7_0215700 PFB0715w DNA-directed RNA polymerase II subunit RPB2 0.4 2.7.7.6
24059 PF3D7_0202900 PFB0140w
palmitoyltransferase, putative 0.4 2.3.1.-
24113 PF3D7_0616800 PFF0815w
malate:quinone oxidoreductase, putative 0.4 1.1.5.4
24108 PF3D7_0603200 PFF0155w mitochondrial chaperone BCS1, putative 0.4
24133 PF3D7_0803000 PF08_0128 peptidyl-prolyl cis-trans isomerase 0.4 5.2.1.8
24247 PF3D7_1434300 PF14_0324
Hsp70/Hsp90 organizing protein 0.3
24070 PF3D7_0307200 PFC0300c 60S ribosomal protein L7, putative 0.3
24236 PF3D7_1372200 MAL13P1.480 histidine-rich protein III 0.3
24259 PF3D7_1476800 PF14_0738
lysophospholipase, putative 0.3 3.1.1.5
24139 PF3D7_0821300 PF08_0042 ATP-dependent RNA helicase  dhx36, putative 0.3 3.6.4.13
24250 PF3D7_1445400 PF14_0431
protein serine/threonine kinase-1 0.3 2.7.11.1
24186 PF3D7_1148900 PF11_0505 Plasmodium exported protein, unknown function 0.3
24148 PF3D7_0911900 PFI0580c
inhibitor of cysteine proteases falstatin 0.3
24238 PF3D7_1408900 PF14_0086 tRNA-dihydrouridine synthase, putative 0.2 1.3.1.89
24172 PF3D7_1035200 PF10_0343
S-antigen 0.2
24208 PF3D7_1243700 PFL2100w
ubiquitin-conjugating enzyme E2, putative 0.2 6.3.2.19
24086 PF3D7_0408700 PFD0430c
perforin-like protein 1 0.2
24242 PF3D7_1424100 PF14_0230 60S ribosomal protein L5, putative 0.2
24100 PF3D7_0512200 PFE0605c
glutathione synthetase 0.2 6.3.2.3
24077 PF3D7_0320900 PFC0920w
H2A.Z 0.2
24196 PF3D7_1216900 PFL0815w DNA-binding chaperone, putative 0.2
24234 PF3D7_1371600 PF13_0115 erythrocyte binding like protein 1, pseudogene 0.2
24090 PF3D7_0415300 PFD0740w
cdc2-related protein kinase 3 0.2 2.7.11.22
24173 PF3D7_1037500 PF10_0368
dynamin-like protein 0.2
24130 PF3D7_0800300 PF08_0140 erythrocyte membrane protein 1, PfEMP1 0.2
24161 PF3D7_0936800 PFI1780w
Plasmodium exported protein (PHISTc), unknown function 0.2
25813 PF3D7_0405100 PFD0250c protein transport protein Sec24B, putative 0.2
24112 PF3D7_0615500 PFF0750w
cdc2-related protein kinase 5 0.2 2.7.11.22
24054 PF3D7_0113000 PFA0620c
glutamic acid-rich protein 0.1
24207 PF3D7_1243600 PFL2095w translation initiation factor SUI1, putative 0.1
24217 PF3D7_1324800 PF13_0140
dihydrofolate synthase/folylpolyglutamate synthase 0.1 6.3.2.12
24232 PF3D7_1367000 MAL13P1.337 suppressor of kinetochore protein 1, putative 0.1
24245 PF3D7_1429800 PF14_0277 coatamer beta subunit, putative 0.1
+ 20 downregulated conserved Plasmodium proteins of unknown function
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