Differentially expressed genes in different stages treated with cAMP
Lima WR, Tessarin-Almeida G, Rozanski A, Parreira KS, Moraes MS, Martins DC, Hashimoto RF, Galante PA, Garcia CR. Signaling transcript profile of the asexual intraerythrocytic development cycle of Plasmodium falciparum induced by melatonin and cAMP. Genes Cancer. 2016 7(9-10):323-339. PMID: 28050233
RING
New PfID Old PfID Annotation Fold change EC# Transcript
PF3D7_0107500 PFA0375c lipid/sterol:H+ symporter 7
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PF3D7_1357900 MAL13P1.284 pyrroline-5-carboxylate reductase, putative 7 1.5.1.2
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PF3D7_0817300 PF08_0060 asparagine-rich antigen 6
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PF3D7_1465900 PF14_0627 40S ribosomal protein S3 5
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PF3D7_0611000 PFF0540c SNARE associated Golgi protein, putative 5
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PF3D7_1009200 PF10_0089 small subunit rRNA synthesis-associated protein, putative 5
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PF3D7_1220900 PFL1005c
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heterochromatin protein 1 (HP1) 5
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PF3D7_0212500 PFB0560w conserved Plasmodium protein, unknown function 5
PF3D7_0424600 PFD1170c
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Plasmodium exported protein (PHISTb), unknown function 5
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PF3D7_1211800 PFL0585w polyubiquitin (PfpUB) 5
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PF3D7_1201600 PFL0080c NIMA related kinase 3 (NEK3) 5 2.7.11.1
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PF3D7_0913200 PFI0645w elongation factor 1-beta (EF-1beta) 4
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PF3D7_1255100 PFL2660w rifin,PIR protein (RIF) 4
PF3D7_0600200 PFF0010w erythrocyte membrane protein 1, PfEMP1 (VAR) 4
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PF3D7_0700700 MAL8P1.214 stevor, pseudogene,PIR protein, pseudogene 4
PF3D7_1115900 PF11_0167
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palmitoyltransferase, putative (DHHC9) 3 2.3.1.-
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PF3D7_0922400 PFI1100w
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para-aminobenzoic acid synthetase (pBAS) 3 2.6.1.85
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PF3D7_1040100 PF10_0394 rifin,PIR protein (RIF) 3
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PF3D7_1446400 PF14_0441
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pyruvate dehydrogenase E1 component subunit beta (pdhB) 3 1.2.4.1
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PF3D7_0317600 PFC0775w 40S ribosomal protein S11, putative (RPS11) 3
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PF3D7_0422400 PFD1055w 40S ribosomal protein S19 (RPS19) 3
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PF3D7_0629300 PFF1420w phosphatidylcholine-sterol acyltransferase, putative (PL) 2 2.3.1.43
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PF3D7_0217800 PFB0830w 40S ribosomal protein S26 (RPS26) 2
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PF3D7_1303500 PF13_0019
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sodium/hydrogen exchanger, Na+, H+ antiporter (NHE) 2
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PF3D7_0809600 MAL8P1.113 peptidase family C50, putative 2 3.4.22.49
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+ 12 upregulated conserved Plasmodium proteins of unknown function
PF3D7_1023900 PF10_0232
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chromodomain-helicase-DNA-binding protein 1 homolog, putative (CHD1) 0.5 3.6.4.12
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PF3D7_0114000 PFA0675w exported protein family 1 (EPF1) 0.5
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PF3D7_1238900 PFL1885c
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protein kinase 2 (PK2) 0.5 2.7.11.1
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PF3D7_1308200 PF13_0044
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carbamoyl phosphate synthetase (cpsSII) 0.5 6.3.5.5
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PF3D7_0115500 PFA0755w erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.5
PF3D7_1371800 MAL13P1.110 Plasmodium exported protein, unknown function 0.5
PF3D7_1141800 PF11_0429
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phd finger protein, putative 0.25
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PF3D7_1331400 PF13_0168 CPW-WPC family protein 0.25
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PF3D7_1428700 PF14_0266 conserved protein, unknown function 0.25
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PF3D7_0822000 PF08_0038
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mitochondrial ribosomal protein L4 precursor, putative 0.25
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PF3D7_1343000 MAL13P1.214
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phosphoethanolamine N-methyltransferase (PMT) 0.25 2.1.1.103
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PF3D7_0403800 PFD0185c alpha/beta hydrolase, putative 0.25
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PF3D7_0932100 PFI1560c protein MAM3, putative 0.25
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PF3D7_1130000 PF11_0311 phosphoacetylglucosamine mutase, putative (PAGM) 0.25 5.4.2.3
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PF3D7_0900100 PFI0005w erythrocyte membrane protein 1, PfEMP1 (VAR) 0.25
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PF3D7_0828300 PF08_0010 conserved Plasmodium protein, unknown function 0.25
PF3D7_0828500 PF08_0009 translation initiation factor EIF-2b alpha subunit, putative 0.25
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PF3D7_0424700 PFD1175w
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serine/threonine protein kinase, FIKK family (FIKK4.2) 0.25 2.7.11.1
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PF3D7_0415300 PFD0740w
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cdc2-related protein kinase 3 (CRK3) 0.25 2.7.11.22
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PF3D7_1235700 PFL1725w
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ATP synthase subunit beta, mitochondrial 0.25 3.6.3.14
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PF3D7_1008200 PF10_0080 endonuclease, putative 0.25 4.2.99.18
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PF3D7_1302800 PF13_0014 40S ribosomal protein S7, putative 0.25
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PF3D7_0103400 PFA0170c zinc-carboxypeptidase, putative 0.13 3.4.17.10
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PF3D7_0826100 MAL8P1.23 E3 ubiquitin-protein ligase, putative 0.13 6.3.2.19
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PF3D7_0632500 PFF1580c erythrocyte membrane protein 1, PfEMP1 (VAR) 0.13
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PF3D7_0420000 PFD0970c zinc finger protein, putative 0.13
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PF3D7_0316800 PFC0735w 40S ribosomal protein S15A, putative 0.13
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PF3D7_0617600 PFF0850c
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stevor,PIR protein 0.13
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PF3D7_1200300 PFL0015c rifin,PIR protein (RIF) 0.13
+ 11 downregulated conserved Plasmodium proteins of unknown function
Trophozoite
New PfID Old PfID Annotation
Fold change
EC#
PF3D7_1116600 PF11_0173 oligosaccharyl transferase STT3 subunit, putative 7 2.4.99.18
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PF3D7_0722400 MAL7P1.122 GTP-binding protein, putative 6.1
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PF3D7_1108500 PF11_0097 succinyl-CoA synthetase alpha subunit, putative 5.8 6.2.1.4
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PF3D7_1237600 PFL1820w rRNA processing WD-repeat protein, putative 5.8
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PF3D7_0707800 MAL7P1.23 RAP protein, putative 5.3
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PF3D7_1238800 PFL1880w acyl-CoA synthetase (ACS11) 5.3 6.2.1.3
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PF3D7_1239000 PFL1890c HD superfamily phosphohydrolase protein 5.3 3.1.4.17
PF3D7_1209300 PFL0465c
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telomere repeat-binding zinc finger protein, putative 5.3
PF3D7_0708500 PF07_0030 heat shock protein 86 family protein 4.9
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PF3D7_0913500 PFI0660c protease, putative 4.9
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PF3D7_0518500 PFE0925c
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ATP-dependent RNA helicase DDX23, putative (DDX23) 4.4 3.6.4.13
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PF3D7_0501700 PFE0085c anaphase promoting complex subunit, putative 4.4
PF3D7_1406400 PF14_0061 PPR repeat protein (PPR) 4.4
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PF3D7_1342600 PF13_0233
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myosin A (MyoA) 3.9
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PF3D7_0724300 MAL7P1.130 3-demethylubiquinone-9 3-methyltransferase, putative 3.4 2.1.1.64
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PF3D7_1338100 MAL13P1.190 26S proteasome regulatory subunit RPN3, putative (RPN3) 3.3
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PF3D7_0103800 PFA0190c actin-related protein (ARP1) 3.1
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PF3D7_0627800 PFF1350c acetyl-CoA synthetase, putative (ACS) 2.9 6.2.1.1
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PF3D7_0404700 PFD0230c
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dipeptidyl aminopeptidase 3 (DPAP3) 2.7 3.4.14.4
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PF3D7_1368200 MAL13P1.344
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RNAse L inhibitor protein, putative 2.7
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PF3D7_0810500 MAL8P1.108 protein phosphatase, putative 2.6 3.1.3.16
PF3D7_1428200 PF14_0260 metabolite/drug transporter, putative 2.6
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PF3D7_0703500 MAL7P1.12
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erythrocyte membrane-associated antigen 2.5
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PF3D7_1211900 PFL0590c
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non-SERCA-type Ca2+ -transporting P-ATPase (ATP4) 2.5 3.6.3.8
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PF3D7_1411900 PF14_0117 p1/s1 nuclease, putative 2.4 3.1.30.1
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PF3D7_1029600 PF10_0289
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adenosine deaminase (ADA) 2.4 3.5.4.4
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PF3D7_1200200 PFL0010c rifin,PIR protein (RIF) 2.3
PF3D7_0316600 PFC0725c
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formate-nitrite transporter, putative 2.3
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PF3D7_1238900 PFL1885c
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protein kinase 2 (PK2) 2.2 2.7.11.1
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PF3D7_1430100 PF14_0280
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serine/threonine protein phosphatase 2A activator (PTPA) 2.2
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PF3D7_1216200 PFL0780w glycerol-3-phosphate dehydrogenase [NAD+], putative 2.1 1.1.1.8
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PF3D7_0917900 PFI0875w
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heat shock protein 70 (HSP70-2) 2.1
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PF3D7_0207700 PFB0345c
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serine repeat antigen 4 (SERA4) 2 3.4.22.-
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+ 16 upregulated conserved Plasmodium proteins of unknown function
PF3D7_1334700 PF13_0194
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MSP7-like protein (MSRP7) 0.5
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PF3D7_0905400 PFI0265c
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high molecular weight rhoptry protein 3 (RhopH3) 0.5
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PF3D7_0929400 PFI1445w
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high molecular weight rhoptry protein 2 (RhopH2) 0.5
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PF3D7_1303500 PF13_0019
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sodium/hydrogen exchanger, Na+, H+ antiporter (NHE) 0.4
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PF3D7_0204900 PFB0220w 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial, putative 0.4 2.1.1.201
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PF3D7_1362400 MAL13P1.310
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calpain (Pcalp) 0.4 3.4.22.-
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PF3D7_0313100 PFC0550w ubiquitin-protein ligase, putative (HRD3) 0.4 6.3.2.19
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PF3D7_1343600 MAL13P1.218 UDP-N-acetylglucosamine pyrophosphorylase, putative 0.4 2.7.7.23
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PF3D7_0717700 PF07_0073
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serine--tRNA ligase, putative 0.3 6.1.1.11
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PF3D7_0411900 PFD0590c DNA polymerase alpha 0.3 2.7.7.7
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PF3D7_1466400 PF14_0633 AP2 domain transcription factor AP2-SP 0.3
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PF3D7_1339900 PF13_0218
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ABC transporter (MDR family), putative (MDR5) 0.3 3.6.3.44
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PF3D7_0303900 PFC0176c phosphatidylethanolamine-binding protein, putative 0.3
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PF3D7_0506900 PFE0340c
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rhomboid protease ROM4 (ROM4) 0.3 3.4.21.105
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PF3D7_0505300 PFE0260w UDP-N-acetyl glucosamine:UMP antiporter 0.3
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PF3D7_1447000 PF14_0448 40S ribosomal protein S5 0.3
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PF3D7_0809500 MAL8P1.114 histone acetyltransferase subunit NuA4, putative 0.2
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PF3D7_1249900 PFL2395c apicoplast dimethyladenosine synthase, putative 0.2 2.1.1.62
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PF3D7_0400200 PFD0010w erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.2
PF3D7_0402400 PFD0115c
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Plasmodium exported protein, unknown function (GEXP18) 0.2
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PF3D7_0509000 SNAP protein (soluble N-ethylmaleimide-sensitive factor attachment protein), putative 0.2
PF3D7_0217800 PFB0830w 40S ribosomal protein S26 (RPS26) 0.2
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PF3D7_1017200 PF10_0167
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enoyl-CoA hydratase-related protein, putative 0.2 4.2.1.17
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PF3D7_0310700 PFC0445w trafficking protein particle complex subunit 4, putative 0.2
PF3D7_0216000 PFB0730w DEAD/DEAH box helicase, putative 0.2 3.6.4.13
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PF3D7_1116000 PF11_0168
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rhoptry neck protein 4 (RON4) 0.1
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PF3D7_1205800 PFL0290w high mobility group protein B3, putative (HMGB3) 0.1
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PF3D7_1334800 MAL13P1.174
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MSP7-like protein (MSRP2) 0.1
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PF3D7_1229300 PFL1415w conserved Plasmodium protein, unknown function 0.1
PF3D7_1011000 PF10_0107 inner membrane complex sub-compartment protein 1, putative (ISP1) 0.1
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+ 12 downregulated conserved Plasmodium proteins of unknown function
Schizont
New PfID Old PfID Annotation