Differential proteome analysis under drug treatment
Prieto JH, Fischer E, Koncarevic S, Yates J, Becker K. Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment. Methods Mol Biol. 2015;1201:269-79. PMID: 25388121.
Artemisinin
PfID Annotation Fold change EC Transcript
PFC0262c conserved Plasmodium protein, unknown function 31.43
PF13_0199 conserved Plasmodium protein, unknown function 9.62
PF14_0215
Image left : 8px, top : 12px
Image left : 8px, top : 12px
ERAD-associated E3 ubiquitin-protein ligase HRD1 8.46 6.3.2.19
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PFL2465c
Image left : 8px, top : 12px
thymidylate kinase 4.88 2.7.4.9
PFB0835c conserved Plasmodium protein, unknown function 3.40
PFE1250w acyl-CoA synthetase 3.11 6.2.1.3
Image left : 32px, top : 4px
PFF0920c conserved protein, unknown function 3.07
PF10_0111
Image left : 8px, top : 12px
Image left : 8px, top : 12px
proteasome subunit beta type-5 2.95 3.4.25.1
Image left : 32px, top : 4px
PF11_0142 ubiquitin domain-containing protein DSK2 2.94
Image left : 32px, top : 4px
PFI0975c regulator of chromosome condensation 2.75
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PFF0445w conserved Plasmodium protein, unknown function 2.52
PF11_0061
Image left : 8px, top : 12px
histone H4 2.34
Image left : 32px, top : 4px
PF14_0242
Image left : 8px, top : 12px
protein arginine N-methyltransferase 1 2.09 2.1.1.125
Image left : 32px, top : 4px
PF10_0043 60S ribosomal protein L13 2.02
Image left : 32px, top : 4px
PFF0510w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
histone H3 1.96
PFD1035w steroid dehydrogenase 1.94 1.1.1.35
Image left : 32px, top : 4px
PFL1500w
Image left : 8px, top : 12px
ras-related protein Rab-2 1.92 3.6.5.2
Image left : 32px, top : 4px
PF08_0121
Image left : 8px, top : 12px
peptidyl-prolyl cis-trans isomerase 1.90 5.2.1.8
Image left : 32px, top : 4px
PFL0300c
Image left : 8px, top : 12px
shewanella-like protein phosphatase 2 1.89 3.1.3.16
Image left : 32px, top : 4px
PFC0535w 60S ribosomal protein L26 1.86
Image left : 32px, top : 4px
PFL2390c THO complex subunit 2 1.86
Image left : 32px, top : 4px
PF13_0224 60S ribosomal subunit protein L18 1.84
Image left : 32px, top : 4px
PFF0885w 60S ribosomal protein L27a 1.82
Image left : 32px, top : 4px
PF07_0040
Image left : 8px, top : 12px
Image left : 8px, top : 12px
prodrug activation and resistance esterase 1.80 3.1.-.-
Image left : 32px, top : 4px
PFE1150w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
multidrug resistance protein 1 1.75 3.6.3.44
Image left : 32px, top : 4px
PFC0915w
Image left : 8px, top : 12px
ATP-dependent RNA helicase DDX6 1.69 3.6.4.13
Image left : 32px, top : 4px
PFE0915c
Image left : 8px, top : 12px
proteasome subunit beta type-1 1.69 3.4.25.1
Image left : 32px, top : 4px
MAL13P1.343 26S proteasome regulatory subunit RPN11 1.63
Image left : 32px, top : 4px
PFD0385w conserved Plasmodium protein, unknown function 1.61
PF11_0384 clptm1 domain-containing protein, putative 1.60
Image left : 32px, top : 4px
PF14_0567 conserved Plasmodium protein, unknown function 1.60
PFC0945w
Image left : 8px, top : 12px
protein kinase 1.58 2.7.11.17
Image left : 32px, top : 4px
PFD1070w eukaryotic initiation factor 4A-III 1.57
Image left : 32px, top : 4px
PF11_0053 chromatin remodeling protein SNF2L 1.53
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MAL8P1.127 conserved Plasmodium protein, unknown function 1.52
PFC0720w kinetochore protein NUF2 1.50
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MAL7P1.38 regulator of chromosome condensation 1.49
Image left : 32px, top : 4px
PF13_0252
Image left : 8px, top : 12px
Image left : 8px, top : 12px
nucleoside transporter 1 1.47
Image left : 32px, top : 4px
PFL0720w conserved Plasmodium membrane protein, unknown function 1.45
PF11_0424 conserved Plasmodium protein, unknown function 1.45
PFL1550w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
dihydrolipoyl dehydrogenase, mitochondrial 1.40 1.8.1.4
Image left : 32px, top : 4px
PFE0340c
Image left : 8px, top : 12px
rhomboid protease ROM4 1.35 3.4.21.105
Image left : 32px, top : 4px
PF13_0102 translocation protein SEC63 1.34
Image left : 32px, top : 4px
PFC0900w T-complex protein 1 epsilon subunit 1.31
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PF14_0231 60S ribosomal protein L7-3 1.31
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PFL1620w asparagine and aspartate rich protein 1 1.28
Image left : 32px, top : 4px
PFL0580w DNA replication licensing factor MCM5 1.26
Image left : 32px, top : 4px
PF13_0198
Image left : 8px, top : 12px
reticulocyte binding protein 2 homolog a 1.24
Image left : 32px, top : 4px
PFL1420w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
macrophage migration inhibitory factor 1.22 5.3.2.1
Image left : 32px, top : 4px
PFI1175c RNA-binding protein 1.21
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PFI0235w replication protein A1, small fragment 1.14
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MAL13P1.307 iron-sulfur assembly protein 1.11
Image left : 32px, top : 4px
MAL8P1.82 vacuolar protein sorting-associated protein 9 1.09
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PF11_0348 RNA (uracil-5-)methyltransferase 1.06 2.1.1.35
Image left : 32px, top : 4px
PFI0290c coatomer subunit beta 1.02
Image left : 32px, top : 4px
PFC0365w pre-mRNA-processing factor 19 1.02
Image left : 32px, top : 4px
PFF0335c conserved plasmodium protein, unknown function 0.99
PF07_0073
Image left : 8px, top : 12px
serine--tRNA ligase 0.97 6.1.1.11
Image left : 32px, top : 4px
PF14_0241 basic transcription factor 3b 0.93
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PF10_0031 conserved Plasmodium protein, unknown function 0.91
PFL1705w CCR4-NOT transcription complex subunit 4 0.86
PFC0390w N2227-like protein, 0.84
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PFF0615c
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6-cysteine protein 0.74
Image left : 32px, top : 4px
PF11_0396
Image left : 8px, top : 12px
Image left : 8px, top : 12px
protein phosphatase PPM2 0.73 3.1.3.16
Image left : 32px, top : 4px
PFF0860c
Image left : 8px, top : 12px
histone H2A 0.73
Image left : 32px, top : 4px
PF14_0341 glucose-6-phosphate isomerase 0.73 5.3.1.9
Image left : 32px, top : 4px
PFE1350c ubiquitin-conjugating enzyme E2 N 0.72 6.3.2.19
Image left : 32px, top : 4px
PFD1130w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
cysteine-rich protective antigen/RH5-Ripr membrane anchoring protein 0.72
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MAL13P1.92 40S ribosomal protein S19 0.72
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PFL1845c calcyclin binding protein 0.71
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PFC1025w translation machinery-associated protein 7 0.71
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PFF0880c conserved Plasmodium protein, unknown function 0.70
PFD0800c repressor of RNA polymerase III transcription MAF1 0.70
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PFB0640c
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Image left : 8px, top : 12px
protein transport protein SEC31 0.69
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PF10_0170
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conserved Plasmodium protein, unknown function 0.67
PFL1155w
Image left : 8px, top : 12px
GTP cyclohydrolase I 0.66 3.5.4.16
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PF14_0706
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nucleoporin NUP116/NSP116 0.65
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PFC0730w HVA22/TB2/DP1 family protein 0.65
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PF11_0433 conserved Plasmodium protein, unknown function 0.63
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PFB0120w
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early transcribed membrane protein 2 0.58
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PFB0680w
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rhoptry neck protein 6 0.56
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PFL1340c conserved Plasmodium protein, unknown function 0.52
PF13_0011
Image left : 8px, top : 12px
gamete antigen 27/25 0.46
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PF07_0101 conserved Plasmodium protein, unknown function 0.45
PF11_0258
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GrpE protein homolog, mitochondria 0.39
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PFC0135c exportin-1 0.28
Image left : 32px, top : 4px
PF08_0132
Image left : 8px, top : 12px
Image left : 8px, top : 12px
glutamate dehydrogenase 0.23 1.4.1.2
Image left : 32px, top : 4px
MAL7P1.81 eukaryotic translation initiation factor 3 subunit I 0.22
Image left : 32px, top : 4px
PF13_0072 conserved Plasmodium protein, unknown function 0.15
PFB0830w 40S ribosomal protein S26 0.10
Image left : 32px, top : 4px
Chloroquine
PFC0262c conserved Plasmodium protein, unknown function 26.16
PFL0580w DNA replication licensing factor MCM5 5.76
Image left : 32px, top : 4px
PFC0135c exportin-1 5.11
Image left : 32px, top : 4px
MAL13P1.307 iron-sulfur assembly protein 3.40
Image left : 32px, top : 4px
PFI0975c regulator of chromosome condensation 3.18
Image left : 32px, top : 4px
PFF0920c conserved protein, unknown function 3.00
PF11_0061
Image left : 8px, top : 12px
histone H4 2.56
Image left : 32px, top : 4px
PFD1035w steroid dehydrogenase 2.56 1.1.1.35
Image left : 32px, top : 4px
MAL7P1.38 regulator of chromosome condensation 2.28
Image left : 32px, top : 4px
PFD0385w conserved Plasmodium protein, unknown function 2.15
PFL1500w
Image left : 8px, top : 12px
ras-related protein Rab-2 1.96 3.6.5.2
Image left : 32px, top : 4px
PF11_0348 RNA (uracil-5-)methyltransferase 1.86 2.1.1.35
Image left : 32px, top : 4px
PFF0510w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
histone H3 1.79
MAL13P1.92 40S ribosomal protein S19 1.78
Image left : 32px, top : 4px
PFL1420w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
macrophage migration inhibitory factor 1.74 5.3.2.1
Image left : 32px, top : 4px
PFL0300c
Image left : 8px, top : 12px
shewanella-like protein phosphatase 2 1.69 3.1.3.16
Image left : 32px, top : 4px
PF14_0567 conserved Plasmodium protein, unknown function 1.68
PFF0615c
Image left : 8px, top : 12px
6-cysteine protein 1.66
Image left : 32px, top : 4px
PFE1150w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
multidrug resistance protein 1 1.66 3.6.3.44
Image left : 32px, top : 4px
PFL1620w asparagine and aspartate rich protein 1 1.65
Image left : 32px, top : 4px
PF13_0198
Image left : 8px, top : 12px
reticulocyte binding protein 2 homolog a 1.65
Image left : 32px, top : 4px
PFC0730w HVA22/TB2/DP1 family protein 1.61
Image left : 32px, top : 4px
PFF0335c conserved plasmodium protein, unknown function 1.61
PF14_0215
Image left : 8px, top : 12px
Image left : 8px, top : 12px
ERAD-associated E3 ubiquitin-protein ligase HRD1 1.59 6.3.2.19
Image left : 32px, top : 4px
PF11_0424 conserved Plasmodium protein, unknown function 1.56
PFC0365w pre-mRNA-processing factor 19 1.55
Image left : 32px, top : 4px
PFC0900w T-complex protein 1 epsilon subunit 1.55
Image left : 32px, top : 4px
PFI1175c RNA-binding protein 1.52
Image left : 32px, top : 4px
PF07_0073
Image left : 8px, top : 12px
serine--tRNA ligase 1.51 6.1.1.11
Image left : 32px, top : 4px
PFI0290c coatomer subunit beta 1.51
Image left : 32px, top : 4px
PFI0235w replication protein A1, small fragment 1.50
Image left : 32px, top : 4px
PF13_0252
Image left : 8px, top : 12px
Image left : 8px, top : 12px
nucleoside transporter 1 1.49
Image left : 32px, top : 4px
PF14_0231 60S ribosomal protein L7-3 1.48
Image left : 32px, top : 4px
PF13_0224 60S ribosomal subunit protein L18 1.45
Image left : 32px, top : 4px
PFC0945w
Image left : 8px, top : 12px
protein kinase 1.45 2.7.11.17
Image left : 32px, top : 4px
PF13_0102 translocation protein SEC63 1.43
Image left : 32px, top : 4px
PFL1550w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
dihydrolipoyl dehydrogenase, mitochondrial 1.43 1.8.1.4
Image left : 32px, top : 4px
PFL0720w conserved Plasmodium membrane protein, unknown function 1.38
PFD1070w eukaryotic initiation factor 4A-III 1.37
Image left : 32px, top : 4px
PF11_0142 ubiquitin domain-containing protein DSK2 1.37
Image left : 32px, top : 4px
PFC0535w 60S ribosomal protein L26 1.33
Image left : 32px, top : 4px
PFE0340c
Image left : 8px, top : 12px
rhomboid protease ROM4 1.33 3.4.21.105
Image left : 32px, top : 4px
PF08_0132
Image left : 8px, top : 12px
Image left : 8px, top : 12px
glutamate dehydrogenase 1.32 1.4.1.2
Image left : 32px, top : 4px
PF11_0384 clptm1 domain-containing protein, putative 1.29
Image left : 32px, top : 4px
PF07_0040
Image left : 8px, top : 12px
Image left : 8px, top : 12px
prodrug activation and resistance esterase 1.28 3.1.-.-
Image left : 32px, top : 4px
PFL2390c THO complex subunit 2 1.17