Single Gene/enzyme deletions predicted to cause impairment of metabolic networks
Green cells: Single gene enzyme deletions predicted to cause impairment of metabolic network of P. falciparum. Tymoshenko S, Oppenheim RD, Soldati-Favre D, Hatzimanikatis V. Functional genomics of Plasmodium falciparum using metabolic modelling and analysis. Brief Funct Genomics. 2013 12(4):316-27. PubMed PMID: 23793264
Yellow cells: Plata G, Hsiao TL, Olszewski KL, Llinás M, Vitkup D. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol. 2010 6:408. PMID: 20823846
Pink cells: Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB. Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res. 2004 14(5):917-24. PMID: 15078855
Light blue cells: Fatumo S, Plaimas K, Adebiyi E, König R. Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico. Infect Genet Evol. 2011 11(1):201-8. PMID: 20804860
Brown cells: Ludin P, Woodcroft B, Ralph SA, Mäser P. In silico prediction of antimalarial drug target candidates. Int J Parasitol Drugs Drug Resist. 2012 2:191-9. PMID: 24533280;
White cells; Redundant entries in 2 or more DBs.
Functional category PfID Annotation EC# Transcript Literature
Amino acid metabolism MAL13P1.221
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aspartate carbamoyltransferase 2.1.3.2
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Banerjee et al 2012
PFI1090w
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S-adenosylmethionine synthetase 2.5.1.6
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No evidence
PFB0200c
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Aspartate transaminase 2.6.1.1
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No evidence
PFE1050w
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S-adenosyl-L-homocysteine hydrolase 3.3.1.1
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12910461
PF10_0322
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ornithine decarboxylase 4.1.1.17
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6435607
PF14_0334
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glutamate synthase [NADH], putative 1.4.1.14
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14284729
PF10_0322
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ornithine decarboxylase 4.1.1.17
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15980361
PF08_0132
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Glutamate dehydrogenase C 1.4.1.2
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18044977
PFI0320w
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Arginase 3.5.3.1
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19218089
MAL13P1.67
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Methionyl-tRNA formyltransferase 2.1.2.9
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8112305
PFD0285c
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Lysine decarboxylase 4.1.1.18
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1799949
Carbohydrate metabolism PF13_0141
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lactate dehydrogenase 1.1.1.27
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16098967
PF14_0520
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6-phosphogluconate dehydrogenase (decarboxylating) 1.1.1.44
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No evidence
PF14_0598
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Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 1.2.1.12
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No evidence
PFF0530w
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Transketolase 2.2.1.1
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No evidence
PFF1155w
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hexokinase 2.7.1.1
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No evidence
PFI1105w
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Phosphoglycerate kinase 2.7.2.3
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No evidence
PF13_0157 phosphoribosyl pyrophosphate synthase 2.7.6.1
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No evidence
PF14_0511
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glucose-6-phosphate dehydrogenase, 6-phospho-gluconolactonase 1.1.1.49
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16689939
PF14_0425
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aldolase 4.1.2.13
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10477179
PF10_0155
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Phosphopyruvate hydratase / enolase 4.2.1.11
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21949403
PF13_0234
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PEP carboxykinase 4.1.1.49
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10779599
PF14_0246
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PEP carboxylase 4.1.1.31
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8704306
PFF0230c
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glyoxalase i-like protein gilp 8304987
PFL0960w
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Ribulose-phosphate 3-epimerase 5.1.3.1
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No evidence
PF14_0378
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triosephosphate isomerase 5.3.1.1
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8552672
PF14_0341 Glucose-6-phosphate isomerase 5.3.1.9
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No evidence
PF10_0122 Phosphoglucomutase 5.4.2.2
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No evidence
PFL2510w Chitinase 3.2.1.14
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11349074
PF13_0144
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lactate dehydrogenase 1.1.1.27
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17920591
PF11_0145
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glyoxalase I 4.4.1.5
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8304987
PFI0960w
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Dolichyl-diphosphooligosaccharide–protein glycosyltransferase 2.4.1.119 No evidence
PFL0285w
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targeted glyoxalase II 3.1.2.6
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16159313
PF10_0210
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Deoxyribose-phosphate aldolase 4.1.2.4
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No evidence
MAL8P1.156
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Mannose-6-P isomerase 5.3.1.8
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7794901
Nucleotide metabolism PFI1020c
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IMP dehydrogenase 1.1.1.205
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7047569
PFE0660c
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purine nucleoside phosphorylase 2.4.2.1
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22096507
PFE0630c
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orotate phosphoribosyltransferase 2.4.2.10
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15003844
PF10_0121
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hypoxanthine guanine phosphoribosyltransferase 2.4.2.8
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8366890
PFI1420w
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Guanylate kinase 2.7.4.8
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No evidence
PFL2465c
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thymidylate kinase 2.7.4.9 No evidence
multiple genes 3',5'-cyclic-nucleotide phosphodiesterase 18452584
PF10_0289
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adenosine deaminase 3.5.4.4
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19728741
PF10_0225
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orotidine-5'-phosphate decarboxylase 4.1.1.23
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15683248
PF11_0411
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Carbonic anhydrase 4.2.1.1
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15499996
PFB0295w
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adenylosuccinate lyase 4.3.2.2
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19111634
PF14_0100
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CTP synthase 6.3.4.2
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No evidence
PF10_0123
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GMP synthase 6.3.5.2
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10631077
PF13_0044
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carbamoyl phosphate synthetase 6.3.5.5
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9202005
MAL13P1.301 Guanylyl cyclase 4.6.1.2
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17030505
PFF0160c
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Dihydroorotate oxidase (fumarate)/dihydroorotate dehydrogenase 1.3.5.2
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19640844
PF10_0154
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Ribonucleoside reductase 1.17.4.1
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8265664
PF14_0053
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Ribonucleoside reductase 1.17.4.1
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8265664
PF14_0352
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Ribonucleoside reductase 1.17.4.1
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8265664
PF11_0411
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Carbonic anhydrase 4.2.1.1
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18805693
PF13_0287
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adenylosuccinate synthase 6.3.4.4
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15500910
Lipid metabolism PF14_0641
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1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267
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17568945
PF10_0221
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(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase 1.17.7.1
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No evidence
PFF0730c
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enoyl-ACP-reductase 1.3.1.9
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19068099
PFL1780w Protein S-isoprenylcysteine-O-methyltransferase 2.1.1.100
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No evidence
MAL13P1.214
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phosphoethanolamine N-methyltransferase 2.1.1.103
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18694927
MAL13P1.186
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1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7
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15452112
PFL0620c
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Glycerol 3-phosphate O-Acyltransferase 2.3.1.15
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16127032
PFE0405c
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sphingosine N-acyltransferase 2.3.1.24
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11166384
PFB0505c
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beta-ketoacyl-ACP synthase 2.3.1.180
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19191586
PF14_0155
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serine palmitoyltransferase, putative 2.3.1.50
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11166384
PF11_0295
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Geranyltranstransferase, dimethylallyltranstransferase 2.5.1.29
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21084289
PF08_0095
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dihydropteroate synthase 2.5.1.15
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9391132
PF11_0301
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Spermidine synthase 2.5.1.16
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20385001
PFF0120w geranylgeranyl transferase type-2 subunit beta, putative 2.5.1.59
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18686940
PFE0150c
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4-diphosphocytidyl-2C-methyl-D-erythritol kinase 2.7.1.148
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No evidence
PF14_0020
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choline kinase 2.7.1.32
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17145794
MAL13P1.86
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CTP:phosphocholine cytidylyltransferase 2.7.7.15
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No evidence
PF14_0097
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phosphatidate cytidylyltransferase 2.7.7.41
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No evidence
PFA0340w
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2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2.7.7.60
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No evidence
PFF1375c
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Ethanolaminephosphotransferase, diacylglycerol cholinephosphotransferase 2.7.8.1
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No evidence
MAL13P1.82
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CDP-diacylglycerol-inositol 3-phosphatidyltransferase 2.7.8.11 No evidence
PFF1215w
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Sphingomyelin synthase 2.7.8.27
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7568097
PFF1210w
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sphingomyelin synthase 1 2.7.8.27
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11166384
PFI1180w
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Patatin-like phospholipase 3.1.1.4
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No evidence
multiple genes lysophospholipase 8022653
MAL8P1.151 Inositol-1,4,5-trisphosphate 5-phosphase 3.1.3.36
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8240417
PFA0515w
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Phosphatidylinositol-4-P-5-kinase 2.7.1.68
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15741172
PF07_0024
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inositol-phosphate phosphatase 3.1.3.25
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No evidence
PF14_0250
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Image left : 8px, top : 12px
Lipase 3.1.1.32
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No evidence
PFL1870c
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Image left : 8px, top : 12px
sphingomyelinase 3.1.4.12
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19088422
PFF1190c
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N-acetylglucosaminylphosphotidylinositol deacetylase 3.5.1.89
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No evidence
PF13_0128
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3-hydroxyacyl-ACP dehydratase 4.2.1.59
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12930838
PFB0420w
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2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12
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16392111
PF10_0409
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Image left : 8px, top : 12px
acetyl-CoA carboxylase 6.4.1.2
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12499205
PFF1275c
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3-oxoacyl-acyl-carrier protein synthase I/II (FABB/F) 2.3.1.41
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19068099
PF14_0788
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Image left : 8px, top : 12px
Adenylyl cyclase 4.6.1.1
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18389080
PFF1420w Phosphatidylcholine-sterol acyltransferase 2.3.1.43
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15590623
PFF0730c
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enoyl-ACP-reductase 1.3.1.9
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11175846
PF11_0483
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Farnesyl-diphosphate famesyltransferase 2.5.1.58
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12194969
PF10_0167
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Enoyl-CoA hydratase 4.2.1.17
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No evidence
PF13_0128
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3-hydroxyacyl-ACP dehydratase 4.2.1.59
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17804795
PFB0695C Long-chain-fatty-acid-CoA ligase 11724382
PF14_0761
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acyl-CoA synthetase 6.2.1.3
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11724382
PFA0225w
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4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1.17.1.2
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17638523
Cofactor synthesis PF11_0169
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Pyridoxine biosynthesis protein PDX2 1.4.3.5
Image left : 32px, top : 4px
No evidence
PFB0279w
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Shikimate dehydrogenase 1.1.1.25
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No evidence
PFF1105c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
chorismate synthase 4.2.3.5
Image left : 32px, top : 4px
11814579
PF13_0070
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3-Methyl-2-oxobutanoate dehydrogenase (BCKDH) 1.2.4.4
Image left : 32px, top : 4px
No evidence
PF11_0436
Image left : 8px, top : 12px
Coproporphyrinogen oxidase 1.3.3.3
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No evidence
PF10_0275
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Protoporphyrinogen oxidase 1.3.3.4
Image left : 32px, top : 4px
20603160
PFD0830w
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Image left : 8px, top : 12px
dihydrofolate reductase 1.5.1.3
Image left : 32px, top : 4px
10722510
PFF1490w Methylenetetrahydrofolate dehydrogenase (NADP+), methenyltetrahydrofolate cyclohydrolase 1.5.1.5
Image left : 32px, top : 4px
16940112
PFD0830w
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Image left : 8px, top : 12px
dihydrofolate reductase 1.5.1.3
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10722510
MAL7P1.130 3-Demethylubiquinone-9,3-O-methyltransferase 2.1.1.64
Image left : 32px, top : 4px
No evidence
PF14_0534
Image left : 8px, top : 12px
serine hydroxymethyltransferase 2.1.2.1
Image left : 32px, top : 4px
No evidence
PFL2210w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
5-aminolevulinate synthase 2.3.1.37
Image left : 32px, top : 4px
1356337
PFF1410c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Nicotinate phosphoribosyltransferase 6.3.4.21
Image left : 32px, top : 4px
No evidence
PFB0280w 3-Phosphoshikimate 1-carboxyvinyltransferase
Image left : 32px, top : 4px
9655396
PFI1100w
Image left : 8px, top : 12px
aminodeoxychorismate synthase 2.6.1.85
Image left : 32px, top : 4px
No evidence
PFI0650c NAD+ kinase 2.7.1.23 No evidence
PF14_0415
Image left : 8px, top : 12px
Dephospho-CoA kinase 2.7.1.24
Image left : 32px, top : 4px
No evidence
PF10_0363
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Pyruvate kinase 2.7.1.40
Image left : 32px, top : 4px
No evidence
PFI1195c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Thiamine diphosphokinase 2.7.6.2
Image left : 32px, top : 4px
No evidence
PF13_0159
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Nicotinate-nucleotide adenylyltransferase 2.7.7.18 20823846
MAL13P1.292 FAD synthetase, riboflavin kinase 2.7.1.26 No evidence
PF08_0068
Image left : 8px, top : 12px
FAD-dependent monooxygenase 1.14.13.8
Image left : 32px, top : 4px
No evidence
PF07_0018
Image left : 8px, top : 12px
Pantetheine-phosphate adenylyltransferase 2.7.7.3
Image left : 32px, top : 4px
No evidence
PF14_0697
Image left : 8px, top : 12px
dihydroorotase 3.5.2.3
Image left : 32px, top : 4px
1348618
PFF0370w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
para-hydroxybenzoate--polyprenyltransferase 2.5.1.39
Image left : 32px, top : 4px
No evidence
MAL8P1.81 Phosphopantothenoylcysteine decarboxylase 4.1.1.36
Image left : 32px, top : 4px
No evidence
PFF0360w
Image left : 8px, top : 12px
Uroporphyrinogen decarboxylase 4.1.1.37
Image left : 32px, top : 4px
No evidence
ORPHAN Chorismate lyase No evidence
PF14_0381
Image left : 8px, top : 12px
Image left : 8px, top : 12px
delta-aminolevulinate dehydratase 4.2.1.24
Image left : 32px, top : 4px
10932227
multiple genes acyl-CoA synthetase No evidence
PF13_0140
Image left : 8px, top : 12px
dihydrofolate synthase 6.3.2.12
Image left : 32px, top : 4px
11223131
PF13_0140
Image left : 8px, top : 12px
dihydrofolate synthase 6.3.2.12
Image left : 32px, top : 4px
11223131
PFI1310w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
NAD+ synthase (glutamine-hydrolysing) 6.3.5.1
Image left : 32px, top : 4px
No evidence
PF14_0200 Pantothenate kinase 16251308
PF14_0354
Image left : 8px, top : 12px
carbonic anhydrase 2.7.1.33
Image left : 32px, top : 4px
16251308
PFF1410c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Nicotinate phosphoribosyltransferase 6.3.4.21
Image left : 32px, top : 4px
17604275
PFF0370w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
para-hydroxybenzoate--polyprenyltransferase 2.5.1.39
Image left : 32px, top : 4px
No evidence
PFF0775w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
pyridoxal kinase 2.7.1.35
Image left : 32px, top : 4px
2387668
PFL1920c
Image left : 8px, top : 12px
Hydroxyethylthiazole kinase 2.7.1.50
Image left : 32px, top : 4px
No evidence
PFE1030c
Image left : 8px, top : 12px
Phosphomethylpyrimidine kinase 2.7.1.49
Image left : 32px, top : 4px
No evidence
PF10_0147
Image left : 8px, top : 12px
FAD synthetase 2.7.7.2
Image left : 32px, top : 4px
No evidence
PFC0910w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Nicotinamidase 3.5.1.19
Image left : 32px, top : 4px
No evidence
PF08_0095
Image left : 8px, top : 12px
dihydropteroate synthase 2.5.1.15
Image left : 32px, top : 4px
9391132
Redox metabolism PF14_0192
Image left : 8px, top : 12px
Image left : 8px, top : 12px
glutathione reductase 1.8.1.7
Image left : 32px, top : 4px
15537352
PF14_0187
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glutathione-S transferase 2.5.1.18