Single Gene/enzyme deletions predicted to cause impairment of metabolic networks
Green cells: Single gene enzyme deletions predicted to cause impairment of metabolic network of P. falciparum. Tymoshenko S, Oppenheim RD, Soldati-Favre D, Hatzimanikatis V. Functional genomics of Plasmodium falciparum using metabolic modelling and analysis. Brief Funct Genomics. 2013 12(4):316-27. PubMed PMID: 23793264
Yellow cells: Plata G, Hsiao TL, Olszewski KL, Llinás M, Vitkup D. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol. 2010 6:408. PMID: 20823846
Pink cells: Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB. Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res. 2004 14(5):917-24. PMID: 15078855
Light blue cells: Fatumo S, Plaimas K, Adebiyi E, König R. Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico. Infect Genet Evol. 2011 11(1):201-8. PMID: 20804860
Brown cells: Ludin P, Woodcroft B, Ralph SA, Mäser P. In silico prediction of antimalarial drug target candidates. Int J Parasitol Drugs Drug Resist. 2012 2:191-9. PMID: 24533280;
White cells; Redundant entries in 2 or more DBs.
Functional category PfID Annotation EC# Transcript Literature
Amino acid metabolism MAL13P1.221
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aspartate carbamoyltransferase 2.1.3.2
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Banerjee et al 2012
PFI1090w
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S-adenosylmethionine synthetase 2.5.1.6
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No evidence
PFB0200c
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Aspartate transaminase 2.6.1.1
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No evidence
PFE1050w
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S-adenosyl-L-homocysteine hydrolase 3.3.1.1
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12910461
PF10_0322
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ornithine decarboxylase 4.1.1.17
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6435607
PF14_0334
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Ornithine aminotransferase 1.4.1.14
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14284729
PF10_0322
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ornithine decarboxylase 4.1.1.17
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15980361
PF08_0132
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Glutamate dehydrogenase C 1.4.1.2
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18044977
PFI0320w
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Arginase 3.5.3.1
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19218089
MAL13P1.67
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Methionyl-tRNA formyltransferase 2.1.2.9
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8112305
PFD0285c
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Lysine decarboxylase 4.1.1.18
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1799949
Carbohydrate metabolism PF13_0141
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lactate dehydrogenase 1.1.1.27
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16098967
PF14_0520
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6-phosphogluconate dehydrogenase (decarboxylating) 1.1.1.44
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No evidence
PF14_0598
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Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 1.2.1.12
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No evidence
PFF0530w
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Transketolase 2.2.1.1
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No evidence
PFF1155w
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hexokinase 2.7.1.1
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No evidence
PFI1105w
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Phosphoglycerate kinase 2.7.2.3
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No evidence
PF13_0157 phosphoribosyl pyrophosphate synthase 2.7.6.1
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No evidence
PF14_0511
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glucose-6-phosphate dehydrogenase, 6-phospho-gluconolactonase 1.1.1.49
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16689939
PF14_0425
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aldolase 4.1.2.13
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10477179
PF10_0155
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Phosphopyruvate hydratase / enolase 4.2.1.11
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21949403
PF13_0234
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PEP carboxykinase 4.1.1.49
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10779599
PF14_0246
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PEP carboxylase 4.1.1.31
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8704306
PFF0230c
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glyoxalase i-like protein gilp 8304987
PFL0960w
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Ribulose-phosphate 3-epimerase 5.1.3.1
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No evidence
PF14_0378
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triosephosphate isomerase 5.3.1.1
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8552672
PF14_0341 Glucose-6-phosphate isomerase 5.3.1.9
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No evidence
PF10_0122 Phosphoglucomutase 5.4.2.2
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No evidence
PFL2510w Chitinase 3.2.1.14
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11349074
PF13_0144
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lactate dehydrogenase 1.1.1.27
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17920591
PF11_0145
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glyoxalase I 4.4.1.5
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8304987
PFI0960w
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Dolichyl-diphosphooligosaccharide–protein glycosyltransferase 2.4.1.119 No evidence
PFL0285w
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targeted glyoxalase II 3.1.2.6
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16159313
PF10_0210
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Deoxyribose-phosphate aldolase 4.1.2.4
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No evidence
MAL8P1.156
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Mannose-6-P isomerase 5.3.1.8
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7794901
Nucleotide metabolism PFI1020c
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IMP dehydrogenase 1.1.1.205
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7047569
PFE0660c
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purine nucleoside phosphorylase 2.4.2.1
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22096507
PFE0630c
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orotate phosphoribosyltransferase 2.4.2.10
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15003844
PF10_0121
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hypoxanthine guanine phosphoribosyltransferase 2.4.2.8
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8366890
PFI1420w
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Guanylate kinase 2.7.4.8
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No evidence
PFL2465c
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thymidylate kinase 2.7.4.9 No evidence
multiple genes 3',5'-cyclic-nucleotide phosphodiesterase 18452584
PF10_0289
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adenosine deaminase 3.5.4.4
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19728741
PF10_0225
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orotidine-5'-phosphate decarboxylase 4.1.1.23
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15683248
PF11_0411
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Carbonic anhydrase 4.2.1.1
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15499996
PFB0295w
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adenylosuccinate lyase 4.3.2.2
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19111634
PF14_0100
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CTP synthase 6.3.4.2
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No evidence
PF10_0123
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GMP synthase 6.3.5.2
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10631077
PF13_0044
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carbamoyl phosphate synthetase 6.3.5.5
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9202005
MAL13P1.301 Guanylyl cyclase 4.6.1.2
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17030505
PFF0160c
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Dihydroorotate oxidase (fumarate)/dihydroorotate dehydrogenase 1.3.5.2
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19640844
PF10_0154
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Ribonucleoside reductase 1.17.4.1
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8265664
PF14_0053
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Ribonucleoside reductase 1.17.4.1
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8265664
PF14_0352
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Ribonucleoside reductase 1.17.4.1
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8265664
PF11_0411
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Carbonic anhydrase 4.2.1.1
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18805693
PF13_0287
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adenylosuccinate synthase 6.3.4.4
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15500910
Lipid metabolism PF14_0641
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1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267
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17568945
PF10_0221
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(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase 1.17.7.1
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No evidence
PFF0730c
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enoyl-ACP-reductase 1.3.1.9
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19068099
PFL1780w Protein S-isoprenylcysteine-O-methyltransferase 2.1.1.100
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No evidence
MAL13P1.214
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phosphoethanolamine N-methyltransferase 2.1.1.103
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18694927
MAL13P1.186
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1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7
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15452112
PFL0620c
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Glycerol 3-phosphate O-Acyltransferase 2.3.1.15
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16127032
PFE0405c
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sphingosine N-acyltransferase 2.3.1.24
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11166384
PFB0505c
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beta-ketoacyl-ACP synthase 2.3.1.180
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19191586
PF14_0155
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serine palmitoyltransferase, putative 2.3.1.50
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11166384
PF11_0295
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Geranyltranstransferase, dimethylallyltranstransferase 2.5.1.29
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21084289
PF08_0095
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dihydropteroate synthase 2.5.1.15
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9391132
PF11_0301
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Spermidine synthase 2.5.1.16
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20385001
PFF0120w geranylgeranyl transferase type-2 subunit beta, putative 2.5.1.59
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18686940
PFE0150c
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4-diphosphocytidyl-2C-methyl-D-erythritol kinase 2.7.1.148
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No evidence
PF14_0020
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choline kinase 2.7.1.32
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17145794
MAL13P1.86
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choline-phosphate cytidylyltransferase 2.7.7.15
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No evidence
PF14_0097
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phosphatidate cytidylyltransferase 2.7.7.41
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No evidence
PFA0340w
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2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2.7.7.60