Essential metabolic genes
Carey MA, Papin JA, Guler JL. Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance. BMC Genomics. 2017 18(1):543. PMID: 28724354
PfID Enzyme EC In vitro method Transcript
PF14_0200
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Pantothenate kinase 2.7.1.33 Inhibitors (several)
Image left : 32px, top : 4px
PF14_0354
Image left : 8px, top : 12px
PF08_0095
Image left : 8px, top : 12px
Dihydropteroate sythetase 2.5.1.15 Inhibitors (several)
Image left : 32px, top : 4px
PFD0830w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Dihydrofolate reductase; thymidylate synthase 1.5.1.3 Inhibitor (1843U89)
Image left : 32px, top : 4px
thymidylate synthase
PF13_0141
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Lactate deydrogenase 1.1.1.27 Inhibitors (Gossypol, others)
Image left : 32px, top : 4px
PF13_0144
Image left : 8px, top : 12px
PF14_0641
Image left : 8px, top : 12px
Image left : 8px, top : 12px
1-Deoxy-D-xylulose-5-phosphate reductoisomerase 1.1.1.267 Inhibitor (Fosmidomycin)
Image left : 32px, top : 4px
PF10_0322
Image left : 8px, top : 12px
Ornithine decarboxylase/ 4.1.1.17 Inhibitors (3-Aminooxy-1-aminopropane, DFMO)
Image left : 32px, top : 4px
S-Adenosylmethionine decarboxylase
PF11_0301
Image left : 8px, top : 12px
Spermidine synthase 2.5.1.16 Inhibitors (4MCHA and others)
Image left : 32px, top : 4px
PFF0730c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
FABI, enoyl-acyl carrier reductase 1.3.1.9 Inhibitor (Triclosan)*
Image left : 32px, top : 4px
PFF1275c
Image left : 8px, top : 12px
FABB/F 3-oxoacyl-acyl-carrier protein synthase I/II 2.3.1.41 Inhibitor (Cerulenin)
Image left : 32px, top : 4px
PF10_0121
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Hypoxanthine phosphoribosyl transferase 2.4.2.8 Antisense oligos
Image left : 32px, top : 4px
PF13_0287
Image left : 8px, top : 12px
Adenylosuccinate synthase 6.3.4.4 Inhibitor (hadacidin)
Image left : 32px, top : 4px
PFB0295w
Image left : 8px, top : 12px
Adenylosuccinate lyase 4.3.2.2 Inhibitors (5-aminoimidazole-4-carboxamide ribonucleoside)
Image left : 32px, top : 4px
PFF0160c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Dihydroorotate dehydrogenase 1.3.5.2 RNAi; Inhibitors (several)
Image left : 32px, top : 4px
PF10_0289
Image left : 8px, top : 12px
Adenosine deaminase 3.5.4.4 Inhibitor (methylthiocoformycin)
Image left : 32px, top : 4px
PFE0660c
Image left : 8px, top : 12px
Purine nucleoside phosphorylase 2.4.2.1 Inhibitor (immucillin-H)
Image left : 32px, top : 4px
PF10_0154
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Ribonucleoside reductase 1.17.4.1 Oligodeoxynucleotide phosphorothioate
Image left : 32px, top : 4px
PF14_0053
Image left : 8px, top : 12px
PF14_0352
Image left : 8px, top : 12px
PF11_0411
Image left : 8px, top : 12px
Image left : 8px, top : 12px
carbonic anhydrase 4.2.1.1 Inhibitors (several)
Image left : 32px, top : 4px
PF13_0044
Image left : 8px, top : 12px
Carbamoyl-phosphate synthase 6.3.5.5 Ribozymes
Image left : 32px, top : 4px
PF11_0282
Image left : 8px, top : 12px
Deoxyuridine 5-triphosphate nucleotidohydrolase 3.6.1.23 Inhibitors (several)
Image left : 32px, top : 4px
PF11_0145
Image left : 8px, top : 12px
Lactoylglutathione lyase 4.4.1.5 Inhibitor (S-p-bromobenzylglutathione diethyl ester)
Image left : 32px, top : 4px
PFF0230c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
PFI1170c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Thioredoxin reductase (NADPH) 1.8.1.9 Gene KO
Image left : 32px, top : 4px
PFB0280w 3-Phosphoshikimate 1-carboxyvinyl transferase Inhibitor (glyphosate)
Image left : 32px, top : 4px
PFF1105c
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Chorismate synthase 4.2.3.5 RNAi
Image left : 32px, top : 4px
PFL1870c
Image left : 8px, top : 12px
Sphingomyelinase 3.1.4.12 Inhibitor (Scyphostatin)
Image left : 32px, top : 4px
PF14_0077
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Plasmepsin II 3.4.23.39 Inhibitors (several)
Image left : 32px, top : 4px
PFL1210w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
apicoplast-targeted isoleucyl-tRNA synthetase 6.1.1.5 Inhibitor (mupirocin)
Image left : 32px, top : 4px
PF13_0179
Image left : 8px, top : 12px
Image left : 8px, top : 12px
cytosolic isoleucyl-tRNA synthetase 6.1.1.5 Inhibitor (Thiaisoleucine)
Image left : 32px, top : 4px
PFI0925w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
gamma-Glutamylcysteine synthase 6.3.2.2 Inhibitor (L-buthionine sulfoximine); fail to Gene KO
Image left : 32px, top : 4px
PF14_0187
Image left : 8px, top : 12px
glutathion s-transferase 2.5.1.18 Inhibitors (ellagic acid, others)
Image left : 32px, top : 4px
PF14_0192
Image left : 8px, top : 12px
Image left : 8px, top : 12px
glutathione reductase 1.8.1.7 Inhibitors (several) fail to KO
Image left : 32px, top : 4px
PF11_0295
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Farnesyl diphosphate synthase 2.5.1.29 Inhibitors (many)
Image left : 32px, top : 4px
PF11_0295
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Farnesyl diphosphate synthase 2.5.1.29 Inhibitors (many)
Image left : 32px, top : 4px
PF13_0269
Image left : 8px, top : 12px
Glycerol kinase 2.7.1.30 Gene KO
Image left : 32px, top : 4px
PF14_0425
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Fructose-biphosphate aldolase 4.1.2.13 Antisense oligos
Image left : 32px, top : 4px
PFL2210w
Image left : 8px, top : 12px
Image left : 8px, top : 12px
5-aminolevulinic acid synthase 2.3.1.37 Gene KO
Image left : 32px, top : 4px
MAL13P1.326
Image left : 8px, top : 12px
Image left : 8px, top : 12px
ferrochelatase 4.99.1.1 Gene KO
Image left : 32px, top : 4px
PF13_0229
Image left : 8px, top : 12px
Image left : 8px, top : 12px
aconitase 4.2.1.3 Gene KO ; Inhibitor (Sodium fluoroacetate)
Image left : 32px, top : 4px
PF14_0164
Image left : 8px, top : 12px
Image left : 8px, top : 12px
glutamate dehydrogenase a 1.4.1.4 Gene KO
Image left : 32px, top : 4px
PF08_0045
Image left : 8px, top : 12px
a-ketoglutarate dehydrogenase 1.2.4.2 Gene KO
Image left : 32px, top : 4px
PF11_0097 succinyl-CoA synthetase 6.2.1.4 Gene KO
Image left : 32px, top : 4px
PF10_0334
Image left : 8px, top : 12px
succinate dehydrogenase 1.3.5.1 Gene KO
Image left : 32px, top : 4px
PF10_0218
Image left : 8px, top : 12px
Image left : 8px, top : 12px
citrate synthase 2.3.3.1 Gene KO
Image left : 32px, top : 4px
PF13_0242 isocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 Gene KO
Image left : 32px, top : 4px
PF10_0275
Image left : 8px, top : 12px
Image left : 8px, top : 12px
Protoporphyrinogen oxidase 1.3.3.4 Inhibitor (Acifluorfen)
Image left : 32px, top : 4px
PF10_0409
Image left : 8px, top : 12px
biotin-acetyl-CoA-carboxylase, putative 6.4.1.2 Inhibitor (Haloxyfops, Fluazifops, Quizalofops)
Image left : 32px, top : 4px
PF14_0664
Image left : 8px, top : 12px
Image left : 8px, top : 12px
biotin carboxylase subunit of acetyl CoA carboxylase
PF14_0381
Image left : 8px, top : 12px
Image left : 8px, top : 12px
alpha-Amino-levulinic acid dehydrogenase 4.2.1.24 Inhibitor (Succinyl acetone)
Image left : 32px, top : 4px
Bold = conflicting experimental results
Online articles related to Essential metabolic genes retrieved from PubMed