Essential metabolic genes
Carey MA, Papin JA, Guler JL. Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance. BMC Genomics. 2017 18(1):543. PMID: 28724354
PfID Enzyme EC In vitro method Transcript
PF3D7_1420600
Image left : 8px, top : 12px
Image left : 8px, top : 12px
pantothenate kinase 1, putative 2.7.1.33 Inhibitors (several)
Image left : 32px, top : 4pxImage left : 32px, top : 46px
PF3D7_1437400
Image left : 8px, top : 12px
PF3D7_0810800
Image left : 8px, top : 12px
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase 2.5.1.15 Inhibitors (several)
Image left : 32px, top : 4px
PF3D7_0417200
Image left : 8px, top : 12px
Image left : 8px, top : 12px
bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 Inhibitor (1843U89)
Image left : 32px, top : 4px
thymidylate synthase
PF3D7_1324900
Image left : 8px, top : 12px
Image left : 8px, top : 12px
L-lactate dehydrogenase 1.1.1.27 Inhibitors (Gossypol, others)
Image left : 32px, top : 4pxImage left : 32px, top : 46px
PF3D7_1325200
Image left : 8px, top : 12px
PF3D7_1467300
Image left : 8px, top : 12px
Image left : 8px, top : 12px
1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 Inhibitor (Fosmidomycin)
Image left : 32px, top : 4px
PF3D7_1033100
Image left : 8px, top : 12px
S-adenosylmethionine decarboxylase/ornithine decarboxylase 4.1.1.17 Inhibitors (3-Aminooxy-1-aminopropane, DFMO)
Image left : 32px, top : 4px
S-Adenosylmethionine decarboxylase
PF3D7_1129000
Image left : 8px, top : 12px
spermidine synthase 2.5.1.16 Inhibitors (4MCHA and others)
Image left : 32px, top : 4px
PF3D7_0615100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
enoyl-acyl carrier reductase 1.3.1.9 Inhibitor (Triclosan)*
Image left : 32px, top : 4px
PF3D7_0626300
Image left : 8px, top : 12px
3-oxoacyl-acyl-carrier protein synthase I/II 2.3.1.41 Inhibitor (Cerulenin)
Image left : 32px, top : 4px
PF3D7_1012400
Image left : 8px, top : 12px
Image left : 8px, top : 12px
hypoxanthine-guanine phosphoribosyltransferase 2.4.2.8 Antisense oligos
Image left : 32px, top : 4px
PF3D7_1354500
Image left : 8px, top : 12px
adenylosuccinate synthetase 6.3.4.4 Inhibitor (hadacidin)
Image left : 32px, top : 4px
PF3D7_0206700
Image left : 8px, top : 12px
adenylosuccinate lyase 4.3.2.2 Inhibitors (5-aminoimidazole-4-carboxamide ribonucleoside)
Image left : 32px, top : 4px
PF3D7_0603300
Image left : 8px, top : 12px
Image left : 8px, top : 12px
dihydroorotate dehydrogenase 1.3.5.2 RNAi; Inhibitors (several)
Image left : 32px, top : 4px
PF3D7_1029600
Image left : 8px, top : 12px
adenosine deaminase 3.5.4.4 Inhibitor (methylthiocoformycin)
Image left : 32px, top : 4px
PF3D7_0513300
Image left : 8px, top : 12px
purine nucleoside phosphorylase 2.4.2.1 Inhibitor (immucillin-H)
Image left : 32px, top : 4px
PF3D7_1015800
Image left : 8px, top : 12px
Image left : 8px, top : 12px
ribonucleoside-diphosphate reductase small chain, putative 1.17.4.1 Oligodeoxynucleotide phosphorothioate
Image left : 32px, top : 4pxImage left : 32px, top : 46pxImage left : 32px, top : 88px
PF3D7_1405600
Image left : 8px, top : 12px
PF3D7_1437200
Image left : 8px, top : 12px
PF3D7_1140000
Image left : 8px, top : 12px
Image left : 8px, top : 12px
carbonic anhydrase 4.2.1.1 Inhibitors (several)
Image left : 32px, top : 4px
PF3D7_1308200
Image left : 8px, top : 12px
carbamoyl phosphate synthetase 6.3.5.5 Ribozymes
Image left : 32px, top : 4px
PF3D7_1127100
Image left : 8px, top : 12px
deoxyuridine 5'-triphosphate nucleotidohydrolase dUTP pyrophosphatase 3.6.1.23 Inhibitors (several)
Image left : 32px, top : 4px
PF3D7_1113700
Image left : 8px, top : 12px
glyoxalase I 4.4.1.5 Inhibitor (S-p-bromobenzylglutathione diethyl ester)
Image left : 32px, top : 4px
PF3D7_0604700
Image left : 8px, top : 12px
Image left : 8px, top : 12px
PF3D7_0923800
Image left : 8px, top : 12px
Image left : 8px, top : 12px
thioredoxin reductase 1.8.1.9 Gene KO
Image left : 32px, top : 4px
PF3D7_0206400 pentafunctional AROM polypeptide, putative, pseudogene Inhibitor (glyphosate)
Image left : 32px, top : 4px
PF3D7_0623000
Image left : 8px, top : 12px
Image left : 8px, top : 12px
chorismate synthase 4.2.3.5 RNAi
Image left : 32px, top : 4px
PF3D7_1238600
Image left : 8px, top : 12px
Image left : 8px, top : 12px
sphingomyelin phosphodiesterase 3.1.4.12 Inhibitor (Scyphostatin)
Image left : 32px, top : 4px
PF3D7_1408000
Image left : 8px, top : 12px
Image left : 8px, top : 12px
plasmepsin II 3.4.23.39 Inhibitors (several)
Image left : 32px, top : 4px
PF3D7_1225100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
isoleucine--tRNA ligase, putative 6.1.1.5 Inhibitor (mupirocin)
Image left : 32px, top : 4px
PF3D7_1332900
Image left : 8px, top : 12px
Image left : 8px, top : 12px
isoleucine--tRNA ligase, putative 6.1.1.5 Inhibitor (Thiaisoleucine)
Image left : 32px, top : 4px
PF3D7_0918900
Image left : 8px, top : 12px
Image left : 8px, top : 12px
gamma-glutamylcysteine synthetase 6.3.2.2 Inhibitor (L-buthionine sulfoximine); fail to Gene KO
Image left : 32px, top : 4px
PF3D7_1419300
Image left : 8px, top : 12px
glutathione S-transferase 2.5.1.18 Inhibitors (ellagic acid, others)
Image left : 32px, top : 4px
PF3D7_1419800
Image left : 8px, top : 12px
Image left : 8px, top : 12px
glutathione reductase 1.8.1.7 Inhibitors (several) fail to KO
Image left : 32px, top : 4px
PF3D7_1128400
Image left : 8px, top : 12px
Image left : 8px, top : 12px
geranylgeranyl pyrophosphate synthase, putative 2.5.1.29 Inhibitors (many)
Image left : 32px, top : 4px
PF3D7_1128400
Image left : 8px, top : 12px
Image left : 8px, top : 12px
geranylgeranyl pyrophosphate synthase, putative 2.5.1.29 Inhibitors (many)
Image left : 32px, top : 4px
PF3D7_1351600
Image left : 8px, top : 12px
glycerol kinase 2.7.1.30 Gene KO
Image left : 32px, top : 4px
PF3D7_1444800
Image left : 8px, top : 12px
Image left : 8px, top : 12px
fructose-bisphosphate aldolase 4.1.2.13 Antisense oligos
Image left : 32px, top : 4px
PF3D7_1246100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
delta-aminolevulinic acid synthetase 2.3.1.37 Gene KO
Image left : 32px, top : 4px
PF3D7_1364900
Image left : 8px, top : 12px
Image left : 8px, top : 12px
ferrochelatase 4.99.1.1 Gene KO
Image left : 32px, top : 4px
PF3D7_1342100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
aconitate hydratase 4.2.1.3 Gene KO ; Inhibitor (Sodium fluoroacetate)
Image left : 32px, top : 4px
PF3D7_1416500
Image left : 8px, top : 12px
Image left : 8px, top : 12px
NADP-specific glutamate dehydrogenase 1.4.1.4 Gene KO
Image left : 32px, top : 4px
PF3D7_0820700
Image left : 8px, top : 12px
2-oxoglutarate dehydrogenase E1 component 1.2.4.2 Gene KO
Image left : 32px, top : 4px
PF3D7_1108500 succinyl-CoA synthetase alpha subunit, putative 6.2.1.4 Gene KO
Image left : 32px, top : 4px
PF3D7_1034400
Image left : 8px, top : 12px
flavoprotein subunit of succinate dehydrogenase 1.3.5.1 Gene KO
Image left : 32px, top : 4px
PF3D7_1022500
Image left : 8px, top : 12px
Image left : 8px, top : 12px
citrate synthase, mitochondrial, putative 2.3.3.1 Gene KO
Image left : 32px, top : 4px
PF3D7_1345700 isocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 Gene KO
Image left : 32px, top : 4px
PF3D7_1028100
Image left : 8px, top : 12px
Image left : 8px, top : 12px
protoporphyrinogen oxidase 1.3.3.4 Inhibitor (Acifluorfen)
Image left : 32px, top : 4px
PF3D7_1026900
Image left : 8px, top : 12px
Image left : 8px, top : 12px
biotin-protein ligase 1 6.4.1.2 Inhibitor (Haloxyfops, Fluazifops, Quizalofops)
Image left : 32px, top : 4pxImage left : 32px, top : 46px
PF3D7_1469600
Image left : 8px, top : 12px
Image left : 8px, top : 12px
acetyl-coa carboxylase
PF3D7_1440300
Image left : 8px, top : 12px
Image left : 8px, top : 12px
delta-aminolevulinic acid dehydratase porphobilinogen synthase 4.2.1.24 Inhibitor (Succinyl acetone)
Image left : 32px, top : 4px
Bold = conflicting experimental results
Online articles related to Essential metabolic genes retrieved from PubMed